Neue Therapiestrategien beim malignen Melanom View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09

AUTHORS

Niels Halama, Inka Zörnig, Dirk Jäger

ABSTRACT

Immunologische Therapien beim malignen Melanom sind wichtige Pfeiler der modernen onkologischen Therapie. Dabei stehen bisher Therapien mit Interleukin-2 oder Interferon im Vordergrund. Diese Therapeutika wurden im Rahmen großer Studien untersucht, insbesondere in adjuvanten Therapiesituationen. Bei fortgeschrittener Erkrankung konnte für Interferon und Interleukin kein wesentlicher Nutzen belegt werden. Vakzinierungstherapien konnten bisher in randomisierten klinischen Studien keinen wesentlichen Vorteil für Melanompatienten zeigen. Neue immunmodulatorische Substanzen sind daher wichtige Bausteine in aktuellen Studien. Weitere immunologische Therapieansätze umfassen allogene und autologe Vakzinierungsstrategien, adoptive T-Zell-Therapie, monoklonale Antikörpertherapien gegen CTLA-4 sowie neue multimodale Ansätze. Letztere kombinieren immunologische Strategien beispielsweise mit konventioneller Chemotherapie oder Strahlentherapie. Neue zielgerichtete Therapien ermöglichen mit dem Eingriff in zelluläre Signalwege (RAS/RAF/MEK, Hedgehog-Signalweg, Hitzeschockprotein 90, mTOR, VEGFR etc.) einen weiteren Weg der spezifischen Intervention. More... »

PAGES

114

References to SciGraph publications

Journal

TITLE

Onkopipeline

ISSUE

3

VOLUME

2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s15035-009-0162-z

DOI

http://dx.doi.org/10.1007/s15035-009-0162-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007601435


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s15035-009-0162-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s15035-009-0162-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s15035-009-0162-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s15035-009-0162-z'


 

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