Tyrosinkinaseinhibitoren beim nichtkleinzelligen Lungenkarzinom View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09

AUTHORS

David F. Heigener

ABSTRACT

Das nichtkleinzellige Lungenkarzinom ist schwer zu therapieren. Mit modernsten Therapieschemata kann im metastasierten Stadium ein mittleres Überleben von knapp über 1 Jahr erreicht werden. Mit der Zulassung der Tyrosinkinaseinhibitoren (TKI) Erlotinib und Gefitinib stehen erstmals sog. kleine Moleküle zur Zweitlinientherapie zur Verfügung, die sich insbesondere durch ihre fehlende Knochenmarktoxizität und ihre orale Verfügbarkeit von der konventionellen Chemotherapie unterscheiden. Seitdem befindet sich eine Reihe weiterer TKI mit verschiedenen Angriffszielen – insbesondere auch im Bereich der Angiogenese – in der klinischen Erprobung. More... »

PAGES

80

References to SciGraph publications

  • 2006-08. Nichtkleinzelliges Lungenkarzinom in DER ONKOLOGE
  • Journal

    TITLE

    Onkopipeline

    ISSUE

    3

    VOLUME

    2

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s15035-009-0155-y

    DOI

    http://dx.doi.org/10.1007/s15035-009-0155-y

    DIMENSIONS

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