Five cases of Plasmodium vivax malaria treated with artemisinin derivatives: the advantages of a unified approach to treatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-26

AUTHORS

Angela Corpolongo, Raffaella Pisapia, Alessandra Oliva, Maria Letizia Giancola, Paola Mencarini, Nazario Bevilacqua, Piero Ghirga, Andrea Mariano, Antonella Vulcano, Maria Grazia Paglia, Emanuele Nicastri

ABSTRACT

OBJECTIVES: In endemic countries with a high level of chloroquine resistance, Plasmodium vivax malaria is associated with high morbidity and mortality. In these areas, the dihydroartemisinin-piperaquine combination resulted in clinical response, a more rapid clearance of parasitaemia, compared to chloroquine therapies, and reduction of recrudescence or reinfection. METHODS: We describe five cases of Plasmodium vivax malaria in returning travelers treated with dihydroartemisinin-piperaquine. RESULTS: All patients showed the early parasite clearance and no side effects. Our preliminary results suggest that the dihydroartemisinin-piperaquine combination is effective and safe even in imported cases. CONCLUSIONS: A unified treatment policy using the artemisinin combination therapy should be adopted even in non-endemic countries and larger studies are underway to support this strategy. More... »

PAGES

1-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s15010-019-01286-6

DOI

http://dx.doi.org/10.1007/s15010-019-01286-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112389746

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30809760


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