Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01-20

AUTHORS

Y. M. Arabi, A. Harthi, J. Hussein, A. Bouchama, S. Johani, A. H. Hajeer, B. T. Saeed, A. Wahbi, A. Saedy, T. AlDabbagh, R. Okaili, M. Sadat, H. Balkhy

ABSTRACT

BackgroundSince the identification of the first case of infection with the Middle East respiratory syndrome corona virus (MERS-CoV) in Saudi Arabia in June 2012, the number of laboratory-confirmed cases has exceeded 941 cases globally, of which 347 died. The disease presents as severe respiratory infection often with shock, acute kidney injury, and coagulopathy. Recently, we observed three cases who presented with neurologic symptoms. These are so far the first reported cases of neurologic injury associated with MERS-CoV infection.MethodsData was retrospectively collected from three patients admitted with MERS-CoV infection to Intensive Care unit (ICU) at King Abdulaziz Medical City, Riyadh. They were managed separately in three different wards prior to their admission to ICU.FindingThe three patients presented with severe neurologic syndrome which included altered level of consciousness ranging from confusion to coma, ataxia, and focal motor deficit. Brain MRI revealed striking changes characterized by widespread, bilateral hyperintense lesions on T2-weighted imaging within the white matter and subcortical areas of the frontal, temporal, and parietal lobes, the basal ganglia, and corpus callosum. None of the lesions showed gadolinium enhancement.InterpretationCNS involvement should be considered in patients with MERS-CoV and progressive neurological disease, and further elucidation of the pathophysiology of this virus is needed. More... »

PAGES

495-501

Journal

TITLE

Infection

ISSUE

4

VOLUME

43

Author Affiliations

  • Intensive Care Department, MC-1425, Respiratory Services, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), P.O. Box 22490, 11426, Riyadh, Kingdom of Saudi Arabia
  • Neuro Physiology Services, Neurology Division, Department of Medicine, King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Neuro Radiology Section, Medical Imaging Department, King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Intensive Care Unit, Experimental Medicine Department, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Microbiology, Pathology and Laboratory Medicine, King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Basic Medical Sciences, Microbiology, Pathology and Laboratory Department, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Cardiac Sciences Department, King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Vascular Surgery, Department of Surgery, King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Infectious Disease Section, Department of Medicine, King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Intensive Care Unit, King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Neuro Radiology, Nuero Interventionalist, Medical Imaging Department, King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Infection Prevention and Control Program, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, 11426, Riyadh, Saudi Arabia
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s15010-015-0720-y

    DOI

    http://dx.doi.org/10.1007/s15010-015-0720-y

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25600929


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    51 corona virus
    52 corpus callosum
    53 deficits
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    57 enhancement
    58 first case
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    66 infection
    67 injury
    68 intensive care unit
    69 involvement
    70 kidney injury
    71 laboratory-confirmed cases
    72 lesions
    73 level of consciousness
    74 levels
    75 lobe
    76 matter
    77 motor deficits
    78 neurologic injury
    79 neurologic symptoms
    80 neurologic syndrome
    81 neurological diseases
    82 number
    83 parietal lobe
    84 pathophysiology
    85 patients
    86 progressive neurological disease
    87 respiratory infections
    88 severe neurologic syndrome
    89 severe respiratory infections
    90 shock
    91 striking changes
    92 subcortical areas
    93 symptoms
    94 syndrome
    95 units
    96 virus
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