Clindamycin–primaquine for pneumocystis jiroveci pneumonia in renal transplant patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-12

AUTHORS

P. Nickel, M. Schürmann, H. Albrecht, R. Schindler, K. Budde, T. Westhoff, J. Millward, N. Suttorp, P. Reinke, D. Schürmann

ABSTRACT

BACKGROUND: Trimethoprim/sulfamethoxazole (TMP/SMX) is considered first-line therapy for pneumocystis jiroveci pneumonia (PCP) in renal transplant patients. Alternatives have not been formally studied. Clindamycin-primaquine (C-P) is effective in HIV-associated PCP, but data in renal transplant patients are lacking. PATIENTS AND METHODS: Retrospective cohort study of 57 consecutive renal transplant patients who developed PCP and were treated with C-P (n = 23) or TMP/SMX (n = 34). RESULTS: A non-significantly higher failure rate was observed in patients on C-P due to lack of efficacy (30.4 versus 20.6%, p = 0.545). The difference was more pronounced in severe PCP (60 versus 37.5%, p = 0.611) and a significantly lower efficacy of C-P was seen when used as salvage therapy. The two patients who had received C-P after not responding to TMP/SMX failed this regimen, but all seven patients who had failed initial treatment with C-P and had been switched to TMP/SMX were cured (p = 0.028). No treatment-limiting adverse reactions were reported for patients on C-P while six patients (17.6%) on TMP/SMX developed possibly related treatment-limiting toxicity (p = 0.071). However, in only two patients adverse events were definitely related to TMP/SMX (5.9%). CONCLUSIONS: Clindamycin-primaquine appears to be safe and well tolerated for treating PCP in renal transplant patients but is probably less effective than TMP/SMX, the standard regimen. However, our data indicates that C-P represents an acceptable alternative for patients with contraindications or treatment emergent toxicities during TMP/SMX use. Notably, TMP/SMX was also acceptably tolerated in most patients. TMP/SMX remains an effective salvage regimen in case of C-P failure. More... »

PAGES

981-989

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s15010-014-0660-y

DOI

http://dx.doi.org/10.1007/s15010-014-0660-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032765339

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25168263


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antifungal Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clindamycin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumocystis carinii", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia, Pneumocystis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Primaquine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trimethoprim, Sulfamethoxazole Drug Combination", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Virchow Klinikum", 
          "id": "https://www.grid.ac/institutes/grid.418434.e", 
          "name": [
            "Division of Nephrology and Intensive Care, Department of Internal Medicine, Campus Virchow-Klinikum, Charit\u00e9-University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nickel", 
        "givenName": "P.", 
        "id": "sg:person.01311403766.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311403766.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virchow Klinikum", 
          "id": "https://www.grid.ac/institutes/grid.418434.e", 
          "name": [
            "Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, Campus Virchow-Klinikum, Charit\u00e9-University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00fcrmann", 
        "givenName": "M.", 
        "id": "sg:person.01055765103.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055765103.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of South Carolina", 
          "id": "https://www.grid.ac/institutes/grid.254567.7", 
          "name": [
            "Division of Infectious Diseases, Department of Internal Medicine, University of South Carolina, Columbia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Albrecht", 
        "givenName": "H.", 
        "id": "sg:person.01267005303.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267005303.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virchow Klinikum", 
          "id": "https://www.grid.ac/institutes/grid.418434.e", 
          "name": [
            "Division of Nephrology and Intensive Care, Department of Internal Medicine, Campus Virchow-Klinikum, Charit\u00e9-University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schindler", 
        "givenName": "R.", 
        "id": "sg:person.01304311142.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304311142.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Division of Nephrology, Department of Internal Medicine, Campus Charit\u00e9 Mitte, Charit\u00e9-University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Budde", 
        "givenName": "K.", 
        "id": "sg:person.01013303206.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013303206.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Division of Nephrology, Department of Internal Medicine, Charit\u00e9-Campus Benjamin Franklin, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Westhoff", 
        "givenName": "T.", 
        "id": "sg:person.01222465204.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222465204.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Medical Immunology, Charit\u00e9-University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Millward", 
        "givenName": "J.", 
        "id": "sg:person.01153623443.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153623443.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virchow Klinikum", 
          "id": "https://www.grid.ac/institutes/grid.418434.e", 
          "name": [
            "Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, Campus Virchow-Klinikum, Charit\u00e9-University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suttorp", 
        "givenName": "N.", 
        "id": "sg:person.0654166733.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654166733.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virchow Klinikum", 
          "id": "https://www.grid.ac/institutes/grid.418434.e", 
          "name": [
            "Division of Nephrology and Intensive Care, Department of Internal Medicine, Campus Virchow-Klinikum, Charit\u00e9-University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reinke", 
        "givenName": "P.", 
        "id": "sg:person.01223262715.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223262715.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virchow Klinikum", 
          "id": "https://www.grid.ac/institutes/grid.418434.e", 
          "name": [
            "Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, Campus Virchow-Klinikum, Charit\u00e9-University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00fcrmann", 
        "givenName": "D.", 
        "id": "sg:person.0727731265.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727731265.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1513/pats.200602-015ms", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000239067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra032588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000647784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm/137.4.796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004539532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.113.5.1215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006934664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dks030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007883085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/598651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010476997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2009.02914.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014736050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2009.02914.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014736050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199011223232131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014827638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.128.2.573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014949565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0025-7125(05)70467-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015314764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0025-7125(05)70467-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015314764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/514696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015883670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s15010-013-0504-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016773754", 
          "https://doi.org/10.1007/s15010-013-0504-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/430257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017734666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/430257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017734666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3181aad256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021515484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3181aad256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021515484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3181aad256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021515484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trim.2013.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023211035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.2009.377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023304094", 
          "https://doi.org/10.1038/ki.2009.377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkp372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025404429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkp372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025404429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2009.02834.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027276447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2009.02834.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027276447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.39.12.2661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027378720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-3062.2011.00691.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029417836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10156-009-0710-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030027600", 
          "https://doi.org/10.1007/s10156-009-0710-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.161.12.1529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030517538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e31816de84d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031012839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e31816de84d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031012839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.transproceed.2008.10.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035693831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2005.01207.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042237060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2005.01207.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042237060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s15010-012-0277-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048408068", 
          "https://doi.org/10.1007/s15010-012-0277-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-5-101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050203717", 
          "https://doi.org/10.1186/1471-2334-5-101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1753465810380102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064075609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1753465810380102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064075609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13693786.2011.571294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070986650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-113-1-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073694665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-124-9-199605010-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073700499"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "BACKGROUND: Trimethoprim/sulfamethoxazole (TMP/SMX) is considered first-line therapy for pneumocystis jiroveci pneumonia (PCP) in renal transplant patients. Alternatives have not been formally studied. Clindamycin-primaquine (C-P) is effective in HIV-associated PCP, but data in renal transplant patients are lacking.\nPATIENTS AND METHODS: Retrospective cohort study of 57 consecutive renal transplant patients who developed PCP and were treated with C-P (n = 23) or TMP/SMX (n = 34).\nRESULTS: A non-significantly higher failure rate was observed in patients on C-P due to lack of efficacy (30.4 versus 20.6%, p = 0.545). The difference was more pronounced in severe PCP (60 versus 37.5%, p = 0.611) and a significantly lower efficacy of C-P was seen when used as salvage therapy. The two patients who had received C-P after not responding to TMP/SMX failed this regimen, but all seven patients who had failed initial treatment with C-P and had been switched to TMP/SMX were cured (p = 0.028). No treatment-limiting adverse reactions were reported for patients on C-P while six patients (17.6%) on TMP/SMX developed possibly related treatment-limiting toxicity (p = 0.071). However, in only two patients adverse events were definitely related to TMP/SMX (5.9%).\nCONCLUSIONS: Clindamycin-primaquine appears to be safe and well tolerated for treating PCP in renal transplant patients but is probably less effective than TMP/SMX, the standard regimen. However, our data indicates that C-P represents an acceptable alternative for patients with contraindications or treatment emergent toxicities during TMP/SMX use. Notably, TMP/SMX was also acceptably tolerated in most patients. TMP/SMX remains an effective salvage regimen in case of C-P failure.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s15010-014-0660-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016707", 
        "issn": [
          "0300-8126", 
          "1439-0973"
        ], 
        "name": "Infection", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "Clindamycin\u2013primaquine for pneumocystis jiroveci pneumonia in renal transplant patients", 
    "pagination": "981-989", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9c16dc004cdfa958b2a77db6497b2690c09e0c5d571e6244e3531012e20ebeea"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25168263"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0365307"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s15010-014-0660-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032765339"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s15010-014-0660-y", 
      "https://app.dimensions.ai/details/publication/pub.1032765339"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs15010-014-0660-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s15010-014-0660-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s15010-014-0660-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s15010-014-0660-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s15010-014-0660-y'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      75 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s15010-014-0660-y schema:about N1df8294430b940e9afad3112db1bacfa
2 N2a436a8397a94fc983359c9b18b39bdf
3 N2ef59f65f24d459892720f5dd5985e37
4 N30218eecbf9448cab10ed81e6968fbf5
5 N4a41bc2e78d24cd9940545c374c21f1c
6 N50bf20e164934dc8b417cf013ba9ea34
7 N56126484cd5847a7b1c715b2ccbadcab
8 N670aa08cd1de4d00890d7bf6a747f491
9 N6ea954161bf64b7eabe0502a4b835352
10 N7542cd99617643d5a87b5ed570990163
11 N76fb8b62acf94ce2ac95f43792321fff
12 N8b4f000eda81424fb86027589697c159
13 N90bd33c1f82b474da2ed09a6326584f8
14 Nadca3bec0c0e4c14bc556f9bb224ce51
15 Nf2862c051919453f9f176d8a8f502226
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N0b01624d77e64c3dbfe9347c165e8573
19 schema:citation sg:pub.10.1007/s10156-009-0710-z
20 sg:pub.10.1007/s15010-012-0277-y
21 sg:pub.10.1007/s15010-013-0504-1
22 sg:pub.10.1038/ki.2009.377
23 sg:pub.10.1186/1471-2334-5-101
24 https://doi.org/10.1001/archinte.161.12.1529
25 https://doi.org/10.1016/j.transproceed.2008.10.027
26 https://doi.org/10.1016/j.trim.2013.05.003
27 https://doi.org/10.1016/s0025-7125(05)70467-3
28 https://doi.org/10.1056/nejm199011223232131
29 https://doi.org/10.1056/nejmra032588
30 https://doi.org/10.1086/430257
31 https://doi.org/10.1086/514696
32 https://doi.org/10.1086/598651
33 https://doi.org/10.1093/jac/dkp372
34 https://doi.org/10.1093/jac/dks030
35 https://doi.org/10.1097/qai.0b013e31816de84d
36 https://doi.org/10.1097/tp.0b013e3181aad256
37 https://doi.org/10.1111/j.1399-3062.2011.00691.x
38 https://doi.org/10.1111/j.1600-6143.2005.01207.x
39 https://doi.org/10.1111/j.1600-6143.2009.02834.x
40 https://doi.org/10.1111/j.1600-6143.2009.02914.x
41 https://doi.org/10.1128/aac.39.12.2661
42 https://doi.org/10.1164/ajrccm/137.4.796
43 https://doi.org/10.1177/1753465810380102
44 https://doi.org/10.1378/chest.113.5.1215
45 https://doi.org/10.1378/chest.128.2.573
46 https://doi.org/10.1513/pats.200602-015ms
47 https://doi.org/10.3109/13693786.2011.571294
48 https://doi.org/10.7326/0003-4819-113-1-14
49 https://doi.org/10.7326/0003-4819-124-9-199605010-00003
50 schema:datePublished 2014-12
51 schema:datePublishedReg 2014-12-01
52 schema:description BACKGROUND: Trimethoprim/sulfamethoxazole (TMP/SMX) is considered first-line therapy for pneumocystis jiroveci pneumonia (PCP) in renal transplant patients. Alternatives have not been formally studied. Clindamycin-primaquine (C-P) is effective in HIV-associated PCP, but data in renal transplant patients are lacking. PATIENTS AND METHODS: Retrospective cohort study of 57 consecutive renal transplant patients who developed PCP and were treated with C-P (n = 23) or TMP/SMX (n = 34). RESULTS: A non-significantly higher failure rate was observed in patients on C-P due to lack of efficacy (30.4 versus 20.6%, p = 0.545). The difference was more pronounced in severe PCP (60 versus 37.5%, p = 0.611) and a significantly lower efficacy of C-P was seen when used as salvage therapy. The two patients who had received C-P after not responding to TMP/SMX failed this regimen, but all seven patients who had failed initial treatment with C-P and had been switched to TMP/SMX were cured (p = 0.028). No treatment-limiting adverse reactions were reported for patients on C-P while six patients (17.6%) on TMP/SMX developed possibly related treatment-limiting toxicity (p = 0.071). However, in only two patients adverse events were definitely related to TMP/SMX (5.9%). CONCLUSIONS: Clindamycin-primaquine appears to be safe and well tolerated for treating PCP in renal transplant patients but is probably less effective than TMP/SMX, the standard regimen. However, our data indicates that C-P represents an acceptable alternative for patients with contraindications or treatment emergent toxicities during TMP/SMX use. Notably, TMP/SMX was also acceptably tolerated in most patients. TMP/SMX remains an effective salvage regimen in case of C-P failure.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf N39322a5551b54de6a0623e30eb7180a5
57 Nda6b2b21fbf344de81307ccf2dda95d4
58 sg:journal.1016707
59 schema:name Clindamycin–primaquine for pneumocystis jiroveci pneumonia in renal transplant patients
60 schema:pagination 981-989
61 schema:productId N8ae89b3c152244778564a0869cab00e6
62 N8c35cd2ee06747069f71e4ef5229bfce
63 N9b30311e76d8494385cc3465905d9bfa
64 Nd9311813c2f74480b61d38bf1193a692
65 Nea952b5b1e824855972ad0b7527b39da
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032765339
67 https://doi.org/10.1007/s15010-014-0660-y
68 schema:sdDatePublished 2019-04-10T23:27
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher Ne9500ef32e42424daf542df40b76a74d
71 schema:url http://link.springer.com/10.1007%2Fs15010-014-0660-y
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0b01624d77e64c3dbfe9347c165e8573 rdf:first sg:person.01311403766.26
76 rdf:rest Nc716742990c245039092417b6e9a8670
77 N1418b88d68cd450a8ee3404435265abb rdf:first sg:person.01013303206.91
78 rdf:rest N8ad4f1d7a8384510a40856788be05f56
79 N1df8294430b940e9afad3112db1bacfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Middle Aged
81 rdf:type schema:DefinedTerm
82 N2a436a8397a94fc983359c9b18b39bdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Pneumonia, Pneumocystis
84 rdf:type schema:DefinedTerm
85 N2ef59f65f24d459892720f5dd5985e37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Antifungal Agents
87 rdf:type schema:DefinedTerm
88 N30218eecbf9448cab10ed81e6968fbf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Trimethoprim, Sulfamethoxazole Drug Combination
90 rdf:type schema:DefinedTerm
91 N39322a5551b54de6a0623e30eb7180a5 schema:issueNumber 6
92 rdf:type schema:PublicationIssue
93 N440e1ce731d94004bc731db93a407a13 rdf:first sg:person.01153623443.25
94 rdf:rest N55257e866428443a94b6130f28496d19
95 N4a41bc2e78d24cd9940545c374c21f1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Retrospective Studies
97 rdf:type schema:DefinedTerm
98 N50bf20e164934dc8b417cf013ba9ea34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Clindamycin
100 rdf:type schema:DefinedTerm
101 N55257e866428443a94b6130f28496d19 rdf:first sg:person.0654166733.58
102 rdf:rest N63662939d11a48c3ab2af376c8f8ef81
103 N56126484cd5847a7b1c715b2ccbadcab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Aged
105 rdf:type schema:DefinedTerm
106 N63662939d11a48c3ab2af376c8f8ef81 rdf:first sg:person.01223262715.72
107 rdf:rest Nfc98e73c1fb44b10aef4df0cc4977486
108 N670aa08cd1de4d00890d7bf6a747f491 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Male
110 rdf:type schema:DefinedTerm
111 N6ea954161bf64b7eabe0502a4b835352 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Female
113 rdf:type schema:DefinedTerm
114 N7542cd99617643d5a87b5ed570990163 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cohort Studies
116 rdf:type schema:DefinedTerm
117 N76fb8b62acf94ce2ac95f43792321fff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Humans
119 rdf:type schema:DefinedTerm
120 N8ad4f1d7a8384510a40856788be05f56 rdf:first sg:person.01222465204.05
121 rdf:rest N440e1ce731d94004bc731db93a407a13
122 N8ae89b3c152244778564a0869cab00e6 schema:name readcube_id
123 schema:value 9c16dc004cdfa958b2a77db6497b2690c09e0c5d571e6244e3531012e20ebeea
124 rdf:type schema:PropertyValue
125 N8b4f000eda81424fb86027589697c159 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Primaquine
127 rdf:type schema:DefinedTerm
128 N8c35cd2ee06747069f71e4ef5229bfce schema:name dimensions_id
129 schema:value pub.1032765339
130 rdf:type schema:PropertyValue
131 N90bd33c1f82b474da2ed09a6326584f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Adult
133 rdf:type schema:DefinedTerm
134 N9b30311e76d8494385cc3465905d9bfa schema:name pubmed_id
135 schema:value 25168263
136 rdf:type schema:PropertyValue
137 N9bf7283f076547cebc8673a6f9380ca0 rdf:first sg:person.01304311142.41
138 rdf:rest N1418b88d68cd450a8ee3404435265abb
139 Na3b5f8d025814f718b88c93c10b5d0ad rdf:first sg:person.01267005303.54
140 rdf:rest N9bf7283f076547cebc8673a6f9380ca0
141 Nadca3bec0c0e4c14bc556f9bb224ce51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Kidney Transplantation
143 rdf:type schema:DefinedTerm
144 Nc716742990c245039092417b6e9a8670 rdf:first sg:person.01055765103.26
145 rdf:rest Na3b5f8d025814f718b88c93c10b5d0ad
146 Nd9311813c2f74480b61d38bf1193a692 schema:name nlm_unique_id
147 schema:value 0365307
148 rdf:type schema:PropertyValue
149 Nda6b2b21fbf344de81307ccf2dda95d4 schema:volumeNumber 42
150 rdf:type schema:PublicationVolume
151 Ne9500ef32e42424daf542df40b76a74d schema:name Springer Nature - SN SciGraph project
152 rdf:type schema:Organization
153 Nea952b5b1e824855972ad0b7527b39da schema:name doi
154 schema:value 10.1007/s15010-014-0660-y
155 rdf:type schema:PropertyValue
156 Nf2862c051919453f9f176d8a8f502226 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Pneumocystis carinii
158 rdf:type schema:DefinedTerm
159 Nfc98e73c1fb44b10aef4df0cc4977486 rdf:first sg:person.0727731265.98
160 rdf:rest rdf:nil
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
165 schema:name Clinical Sciences
166 rdf:type schema:DefinedTerm
167 sg:journal.1016707 schema:issn 0300-8126
168 1439-0973
169 schema:name Infection
170 rdf:type schema:Periodical
171 sg:person.01013303206.91 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
172 schema:familyName Budde
173 schema:givenName K.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013303206.91
175 rdf:type schema:Person
176 sg:person.01055765103.26 schema:affiliation https://www.grid.ac/institutes/grid.418434.e
177 schema:familyName Schürmann
178 schema:givenName M.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055765103.26
180 rdf:type schema:Person
181 sg:person.01153623443.25 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
182 schema:familyName Millward
183 schema:givenName J.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153623443.25
185 rdf:type schema:Person
186 sg:person.01222465204.05 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
187 schema:familyName Westhoff
188 schema:givenName T.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222465204.05
190 rdf:type schema:Person
191 sg:person.01223262715.72 schema:affiliation https://www.grid.ac/institutes/grid.418434.e
192 schema:familyName Reinke
193 schema:givenName P.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223262715.72
195 rdf:type schema:Person
196 sg:person.01267005303.54 schema:affiliation https://www.grid.ac/institutes/grid.254567.7
197 schema:familyName Albrecht
198 schema:givenName H.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267005303.54
200 rdf:type schema:Person
201 sg:person.01304311142.41 schema:affiliation https://www.grid.ac/institutes/grid.418434.e
202 schema:familyName Schindler
203 schema:givenName R.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304311142.41
205 rdf:type schema:Person
206 sg:person.01311403766.26 schema:affiliation https://www.grid.ac/institutes/grid.418434.e
207 schema:familyName Nickel
208 schema:givenName P.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311403766.26
210 rdf:type schema:Person
211 sg:person.0654166733.58 schema:affiliation https://www.grid.ac/institutes/grid.418434.e
212 schema:familyName Suttorp
213 schema:givenName N.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654166733.58
215 rdf:type schema:Person
216 sg:person.0727731265.98 schema:affiliation https://www.grid.ac/institutes/grid.418434.e
217 schema:familyName Schürmann
218 schema:givenName D.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727731265.98
220 rdf:type schema:Person
221 sg:pub.10.1007/s10156-009-0710-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1030027600
222 https://doi.org/10.1007/s10156-009-0710-z
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s15010-012-0277-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1048408068
225 https://doi.org/10.1007/s15010-012-0277-y
226 rdf:type schema:CreativeWork
227 sg:pub.10.1007/s15010-013-0504-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016773754
228 https://doi.org/10.1007/s15010-013-0504-1
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/ki.2009.377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023304094
231 https://doi.org/10.1038/ki.2009.377
232 rdf:type schema:CreativeWork
233 sg:pub.10.1186/1471-2334-5-101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050203717
234 https://doi.org/10.1186/1471-2334-5-101
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1001/archinte.161.12.1529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030517538
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.transproceed.2008.10.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035693831
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.trim.2013.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023211035
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0025-7125(05)70467-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015314764
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1056/nejm199011223232131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014827638
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmra032588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000647784
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1086/430257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017734666
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1086/514696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015883670
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1086/598651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010476997
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1093/jac/dkp372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025404429
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1093/jac/dks030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007883085
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1097/qai.0b013e31816de84d schema:sameAs https://app.dimensions.ai/details/publication/pub.1031012839
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1097/tp.0b013e3181aad256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021515484
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1111/j.1399-3062.2011.00691.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029417836
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1600-6143.2005.01207.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042237060
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/j.1600-6143.2009.02834.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027276447
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/j.1600-6143.2009.02914.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014736050
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1128/aac.39.12.2661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027378720
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1164/ajrccm/137.4.796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004539532
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1177/1753465810380102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064075609
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1378/chest.113.5.1215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006934664
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1378/chest.128.2.573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014949565
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1513/pats.200602-015ms schema:sameAs https://app.dimensions.ai/details/publication/pub.1000239067
281 rdf:type schema:CreativeWork
282 https://doi.org/10.3109/13693786.2011.571294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070986650
283 rdf:type schema:CreativeWork
284 https://doi.org/10.7326/0003-4819-113-1-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073694665
285 rdf:type schema:CreativeWork
286 https://doi.org/10.7326/0003-4819-124-9-199605010-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073700499
287 rdf:type schema:CreativeWork
288 https://www.grid.ac/institutes/grid.254567.7 schema:alternateName University of South Carolina
289 schema:name Division of Infectious Diseases, Department of Internal Medicine, University of South Carolina, Columbia, USA
290 rdf:type schema:Organization
291 https://www.grid.ac/institutes/grid.418434.e schema:alternateName Virchow Klinikum
292 schema:name Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, Campus Virchow-Klinikum, Charité-University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
293 Division of Nephrology and Intensive Care, Department of Internal Medicine, Campus Virchow-Klinikum, Charité-University Medicine Berlin, Berlin, Germany
294 rdf:type schema:Organization
295 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
296 schema:name Division of Nephrology, Department of Internal Medicine, Campus Charité Mitte, Charité-University Medicine Berlin, Berlin, Germany
297 Division of Nephrology, Department of Internal Medicine, Charité-Campus Benjamin Franklin, University Medicine Berlin, Berlin, Germany
298 Institute of Medical Immunology, Charité-University Medicine Berlin, Berlin, Germany
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...