Diagnostic performance of serum high-sensitivity procalcitonin and serum C-reactive protein tests for detecting bacterial infection in febrile neutropenia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-07-20

AUTHORS

Mizuki Aimoto, Hideo Koh, Takako Katayama, Hiroshi Okamura, Takuro Yoshimura, Shiro Koh, Satoru Nanno, Mitsutaka Nishimoto, Asao Hirose, Mika Nakamae, Takahiko Nakane, Hirohisa Nakamae, Hiroshi Kakeya, Masayuki Hino

ABSTRACT

PurposeAlthough a few prospective studies have addressed the question as to which biomarker of infection in adult patients with febrile neutropenia (FN) is superior, procalcitonin (PCT) or C-reactive protein (CRP), the results have been inconsistent and inconclusive. This was possibly due to the poor sensitivity of previous PCT tests that have a functional sensitivity of 0.5 ng/ml.MethodsBetween November 2010 and February 2012, we prospectively compared the diagnostic utility of serum high-sensitivity (hs) PCT (lower limit of detection, 0.02 ng/ml) and CRP levels for detecting bacterial infection in patients with FN. Serum was collected within 72 h after the onset of FN in patients with hematological disorders.ResultsSeventy-five febrile episodes were evaluable. The areas under the receiver operating characteristic curves for life-threatening infection defined as septic shock and bacteremia caused by non-coagulase negative staphylococcus were 0.824 (95 % CI 0.711–0.937; P = 0.001) for hsPCT and 0.673 (0.505–0.842; P = 0.068) for CRP, respectively. In contrast, CRP, but not hsPCT, tended to increase significantly with the clinical severity, as indicated by the diagnostic classification (P = 0.002 for trend).ConclusionsThe serum hsPCT test may be more useful than the serum CRP test in the detection of life-threatening infection at an early phase after the onset of FN. In contrast, the serum CRP test may be more useful in diagnosing the severity of infection. However, neither of these tests was able to differentiate the cause of FN with a low probability of fatal outcome. More... »

PAGES

971-979

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s15010-014-0657-6

DOI

http://dx.doi.org/10.1007/s15010-014-0657-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049047931

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25038889


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacteremia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcitonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcitonin Gene-Related Peptide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Febrile Neutropenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Precursors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ROC Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Shock, Septic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aimoto", 
        "givenName": "Mizuki", 
        "id": "sg:person.01045377355.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045377355.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koh", 
        "givenName": "Hideo", 
        "id": "sg:person.01224261751.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224261751.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katayama", 
        "givenName": "Takako", 
        "id": "sg:person.01010703671.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010703671.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okamura", 
        "givenName": "Hiroshi", 
        "id": "sg:person.0777264155.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777264155.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshimura", 
        "givenName": "Takuro", 
        "id": "sg:person.01161625755.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161625755.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koh", 
        "givenName": "Shiro", 
        "id": "sg:person.01061333113.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061333113.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nanno", 
        "givenName": "Satoru", 
        "id": "sg:person.01306147013.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306147013.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishimoto", 
        "givenName": "Mitsutaka", 
        "id": "sg:person.01102773250.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102773250.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirose", 
        "givenName": "Asao", 
        "id": "sg:person.01340510351.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340510351.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamae", 
        "givenName": "Mika", 
        "id": "sg:person.01344167555.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344167555.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakane", 
        "givenName": "Takahiko", 
        "id": "sg:person.01324645723.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324645723.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamae", 
        "givenName": "Hirohisa", 
        "id": "sg:person.01014223462.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Infection Control Science, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Department of Infection Control Science, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kakeya", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01151415704.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151415704.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261445.0", 
          "name": [
            "Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hino", 
        "givenName": "Masayuki", 
        "id": "sg:person.0777446051.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777446051.79"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/cc10242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027373539", 
          "https://doi.org/10.1186/cc10242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-002-0584-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075242439", 
          "https://doi.org/10.1007/s00277-002-0584-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2012.244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028358194", 
          "https://doi.org/10.1038/bmt.2012.244"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-07-20", 
    "datePublishedReg": "2014-07-20", 
    "description": "PurposeAlthough a few prospective studies have addressed the question as to which biomarker of infection in adult patients with febrile neutropenia (FN) is superior, procalcitonin (PCT) or C-reactive protein (CRP), the results have been inconsistent and inconclusive. This was possibly due to the poor sensitivity of previous PCT tests that have a functional sensitivity of 0.5\u00a0ng/ml.MethodsBetween November 2010 and February 2012, we prospectively compared the diagnostic utility of serum high-sensitivity (hs) PCT (lower limit of detection, 0.02\u00a0ng/ml) and CRP levels for detecting bacterial infection in patients with FN. Serum was collected within 72\u00a0h after the onset of FN in patients with hematological disorders.ResultsSeventy-five febrile episodes were evaluable. The areas under the receiver operating characteristic curves for life-threatening infection defined as septic shock and bacteremia caused by non-coagulase negative staphylococcus were 0.824 (95\u00a0% CI 0.711\u20130.937; P\u00a0=\u00a00.001) for hsPCT and 0.673 (0.505\u20130.842; P\u00a0=\u00a00.068) for CRP, respectively. In contrast, CRP, but not hsPCT, tended to increase significantly with the clinical severity, as indicated by the diagnostic classification (P\u00a0=\u00a00.002 for trend).ConclusionsThe serum hsPCT test may be more useful than the serum CRP test in the detection of life-threatening infection at an early phase after the onset of FN. In contrast, the serum CRP test may be more useful in diagnosing the severity of infection. However, neither of these tests was able to differentiate the cause of FN with a low probability of fatal outcome.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s15010-014-0657-6", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016707", 
        "issn": [
          "0300-8126", 
          "1439-0973"
        ], 
        "name": "Infection", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "keywords": [
      "C-reactive protein", 
      "onset of FN", 
      "serum CRP test", 
      "febrile neutropenia", 
      "life-threatening infections", 
      "CRP test", 
      "bacterial infections", 
      "C-reactive protein test", 
      "biomarkers of infection", 
      "severity of infection", 
      "febrile episodes", 
      "adult patients", 
      "CRP levels", 
      "septic shock", 
      "prospective study", 
      "fatal outcome", 
      "clinical severity", 
      "hematological disorders", 
      "procalcitonin", 
      "negative staphylococci", 
      "diagnostic utility", 
      "infection", 
      "patients", 
      "diagnostic performance", 
      "diagnostic classification", 
      "protein test", 
      "neutropenia", 
      "characteristic curve", 
      "poor sensitivity", 
      "functional sensitivity", 
      "PCT test", 
      "early phase", 
      "severity", 
      "onset", 
      "bacteremia", 
      "PurposeAlthough", 
      "biomarkers", 
      "serum", 
      "disorders", 
      "low probability", 
      "test", 
      "outcomes", 
      "episodes", 
      "staphylococci", 
      "cause", 
      "sensitivity", 
      "contrast", 
      "levels", 
      "protein", 
      "study", 
      "shock", 
      "utility", 
      "detection", 
      "classification", 
      "receiver", 
      "curves", 
      "area", 
      "results", 
      "questions", 
      "probability", 
      "phase", 
      "performance"
    ], 
    "name": "Diagnostic performance of serum high-sensitivity procalcitonin and serum C-reactive protein tests for detecting bacterial infection in febrile neutropenia", 
    "pagination": "971-979", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049047931"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s15010-014-0657-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25038889"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s15010-014-0657-6", 
      "https://app.dimensions.ai/details/publication/pub.1049047931"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_638.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s15010-014-0657-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s15010-014-0657-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s15010-014-0657-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s15010-014-0657-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s15010-014-0657-6'


 

This table displays all metadata directly associated to this object as RDF triples.

300 TRIPLES      21 PREDICATES      108 URIs      97 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s15010-014-0657-6 schema:about N0bfaf708fe714cdc963dbf9670796fc4
2 N2244b34c09684a74a649678bd2263b17
3 N2388cf0f9ea14378af4987bf4fef09e9
4 N3f52b89eda074c18a763d49067b20350
5 N775cc9f4a5a742a1aeb97618db425172
6 N81d5ad50e4924ec28708bdd485f9fc02
7 N86598ba365104b65ba79c8795677762b
8 N87ee64e54fd74144ba6d1d6402b07390
9 N99fe9fd85ebe423da4f52b25513ffa7f
10 N9b7f631b6e674f96b7fbf31805330db3
11 Na7157e4b073b4993af1511e4043da4fe
12 Nc3c5973b3bc14da1b93e02a242ff432d
13 Nc4a3ec0549404e63938cca71b29a8eba
14 Nc5115a88d8d643e9bad7d9ba67faf6a9
15 Ncb6945ddf56f49329341a68f791cc01e
16 Nd03020b98c824d9db4b61a1c51bc37e0
17 Ndd1542b150b54eecaef3242d313a2a18
18 Ne439f87a6d7d49ab9bda11ffc654ca85
19 anzsrc-for:11
20 anzsrc-for:1108
21 schema:author N5b811d8cf5564b0db8ab7e345daabc58
22 schema:citation sg:pub.10.1007/s00277-002-0584-y
23 sg:pub.10.1038/bmt.2012.244
24 sg:pub.10.1186/cc10242
25 schema:datePublished 2014-07-20
26 schema:datePublishedReg 2014-07-20
27 schema:description PurposeAlthough a few prospective studies have addressed the question as to which biomarker of infection in adult patients with febrile neutropenia (FN) is superior, procalcitonin (PCT) or C-reactive protein (CRP), the results have been inconsistent and inconclusive. This was possibly due to the poor sensitivity of previous PCT tests that have a functional sensitivity of 0.5 ng/ml.MethodsBetween November 2010 and February 2012, we prospectively compared the diagnostic utility of serum high-sensitivity (hs) PCT (lower limit of detection, 0.02 ng/ml) and CRP levels for detecting bacterial infection in patients with FN. Serum was collected within 72 h after the onset of FN in patients with hematological disorders.ResultsSeventy-five febrile episodes were evaluable. The areas under the receiver operating characteristic curves for life-threatening infection defined as septic shock and bacteremia caused by non-coagulase negative staphylococcus were 0.824 (95 % CI 0.711–0.937; P = 0.001) for hsPCT and 0.673 (0.505–0.842; P = 0.068) for CRP, respectively. In contrast, CRP, but not hsPCT, tended to increase significantly with the clinical severity, as indicated by the diagnostic classification (P = 0.002 for trend).ConclusionsThe serum hsPCT test may be more useful than the serum CRP test in the detection of life-threatening infection at an early phase after the onset of FN. In contrast, the serum CRP test may be more useful in diagnosing the severity of infection. However, neither of these tests was able to differentiate the cause of FN with a low probability of fatal outcome.
28 schema:genre article
29 schema:isAccessibleForFree false
30 schema:isPartOf Nbb39eb4ba82e428fa9bfce4717ba1f83
31 Nf06ae8fe52ae44e58a51951ac487b88e
32 sg:journal.1016707
33 schema:keywords C-reactive protein
34 C-reactive protein test
35 CRP levels
36 CRP test
37 PCT test
38 PurposeAlthough
39 adult patients
40 area
41 bacteremia
42 bacterial infections
43 biomarkers
44 biomarkers of infection
45 cause
46 characteristic curve
47 classification
48 clinical severity
49 contrast
50 curves
51 detection
52 diagnostic classification
53 diagnostic performance
54 diagnostic utility
55 disorders
56 early phase
57 episodes
58 fatal outcome
59 febrile episodes
60 febrile neutropenia
61 functional sensitivity
62 hematological disorders
63 infection
64 levels
65 life-threatening infections
66 low probability
67 negative staphylococci
68 neutropenia
69 onset
70 onset of FN
71 outcomes
72 patients
73 performance
74 phase
75 poor sensitivity
76 probability
77 procalcitonin
78 prospective study
79 protein
80 protein test
81 questions
82 receiver
83 results
84 sensitivity
85 septic shock
86 serum
87 serum CRP test
88 severity
89 severity of infection
90 shock
91 staphylococci
92 study
93 test
94 utility
95 schema:name Diagnostic performance of serum high-sensitivity procalcitonin and serum C-reactive protein tests for detecting bacterial infection in febrile neutropenia
96 schema:pagination 971-979
97 schema:productId N1c03a04cb2a94705bebe7abbb13ddf9b
98 N92bdbe1833524c93946281a4569668bd
99 Ne5516728a3404721ae3a244a18f3a130
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049047931
101 https://doi.org/10.1007/s15010-014-0657-6
102 schema:sdDatePublished 2022-11-24T20:58
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher Nfaa1a229da1c4ec7ba4ef892209caa98
105 schema:url https://doi.org/10.1007/s15010-014-0657-6
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N0955e1562b4c433790a3d5add31796bb rdf:first sg:person.01224261751.45
110 rdf:rest N5613c47ac42747faaaf784cfff2ef191
111 N0b9277052a99468f96feed21c9a1a48f rdf:first sg:person.01306147013.28
112 rdf:rest N402fa1952e8547b3948530d96086be8b
113 N0bfaf708fe714cdc963dbf9670796fc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name C-Reactive Protein
115 rdf:type schema:DefinedTerm
116 N1c03a04cb2a94705bebe7abbb13ddf9b schema:name doi
117 schema:value 10.1007/s15010-014-0657-6
118 rdf:type schema:PropertyValue
119 N2244b34c09684a74a649678bd2263b17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Prospective Studies
121 rdf:type schema:DefinedTerm
122 N2388cf0f9ea14378af4987bf4fef09e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Protein Precursors
124 rdf:type schema:DefinedTerm
125 N3ec1289a543142e4b292440db5efa3f7 rdf:first sg:person.01014223462.98
126 rdf:rest N9b7daeeadf6047b7a71433c9b8caf791
127 N3f52b89eda074c18a763d49067b20350 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name ROC Curve
129 rdf:type schema:DefinedTerm
130 N402fa1952e8547b3948530d96086be8b rdf:first sg:person.01102773250.93
131 rdf:rest N405e8683657749a68a6490c261264846
132 N405e8683657749a68a6490c261264846 rdf:first sg:person.01340510351.20
133 rdf:rest Nab1c842583bb49c3961b186d48f134a8
134 N409ed9e02d814d8491d849a2bd448974 rdf:first sg:person.01324645723.81
135 rdf:rest N3ec1289a543142e4b292440db5efa3f7
136 N5613c47ac42747faaaf784cfff2ef191 rdf:first sg:person.01010703671.38
137 rdf:rest Ne60f66b8e5c843bb99c19e80b7756624
138 N5b811d8cf5564b0db8ab7e345daabc58 rdf:first sg:person.01045377355.65
139 rdf:rest N0955e1562b4c433790a3d5add31796bb
140 N775cc9f4a5a742a1aeb97618db425172 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Shock, Septic
142 rdf:type schema:DefinedTerm
143 N81d5ad50e4924ec28708bdd485f9fc02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Biomarkers
145 rdf:type schema:DefinedTerm
146 N86598ba365104b65ba79c8795677762b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Aged
148 rdf:type schema:DefinedTerm
149 N87ee64e54fd74144ba6d1d6402b07390 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Female
151 rdf:type schema:DefinedTerm
152 N92bdbe1833524c93946281a4569668bd schema:name dimensions_id
153 schema:value pub.1049047931
154 rdf:type schema:PropertyValue
155 N99fe9fd85ebe423da4f52b25513ffa7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Calcitonin Gene-Related Peptide
157 rdf:type schema:DefinedTerm
158 N9b7daeeadf6047b7a71433c9b8caf791 rdf:first sg:person.01151415704.02
159 rdf:rest Ndfdfa35d4c854d1d9f12e185a3c21911
160 N9b7f631b6e674f96b7fbf31805330db3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adult
162 rdf:type schema:DefinedTerm
163 Na7157e4b073b4993af1511e4043da4fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Febrile Neutropenia
165 rdf:type schema:DefinedTerm
166 Nab1c842583bb49c3961b186d48f134a8 rdf:first sg:person.01344167555.69
167 rdf:rest N409ed9e02d814d8491d849a2bd448974
168 Nb2639e086f0c455d87392782be3312de rdf:first sg:person.01161625755.74
169 rdf:rest Nfbe0d1bd2e8c4dcea3036cf6ade1f42b
170 Nbb39eb4ba82e428fa9bfce4717ba1f83 schema:issueNumber 6
171 rdf:type schema:PublicationIssue
172 Nc3c5973b3bc14da1b93e02a242ff432d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Bacteremia
174 rdf:type schema:DefinedTerm
175 Nc4a3ec0549404e63938cca71b29a8eba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Adolescent
177 rdf:type schema:DefinedTerm
178 Nc5115a88d8d643e9bad7d9ba67faf6a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 Ncb6945ddf56f49329341a68f791cc01e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Young Adult
183 rdf:type schema:DefinedTerm
184 Nd03020b98c824d9db4b61a1c51bc37e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Middle Aged
186 rdf:type schema:DefinedTerm
187 Ndd1542b150b54eecaef3242d313a2a18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Calcitonin
189 rdf:type schema:DefinedTerm
190 Ndfdfa35d4c854d1d9f12e185a3c21911 rdf:first sg:person.0777446051.79
191 rdf:rest rdf:nil
192 Ne439f87a6d7d49ab9bda11ffc654ca85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Male
194 rdf:type schema:DefinedTerm
195 Ne5516728a3404721ae3a244a18f3a130 schema:name pubmed_id
196 schema:value 25038889
197 rdf:type schema:PropertyValue
198 Ne60f66b8e5c843bb99c19e80b7756624 rdf:first sg:person.0777264155.36
199 rdf:rest Nb2639e086f0c455d87392782be3312de
200 Nf06ae8fe52ae44e58a51951ac487b88e schema:volumeNumber 42
201 rdf:type schema:PublicationVolume
202 Nfaa1a229da1c4ec7ba4ef892209caa98 schema:name Springer Nature - SN SciGraph project
203 rdf:type schema:Organization
204 Nfbe0d1bd2e8c4dcea3036cf6ade1f42b rdf:first sg:person.01061333113.37
205 rdf:rest N0b9277052a99468f96feed21c9a1a48f
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
210 schema:name Medical Microbiology
211 rdf:type schema:DefinedTerm
212 sg:journal.1016707 schema:issn 0300-8126
213 1439-0973
214 schema:name Infection
215 schema:publisher Springer Nature
216 rdf:type schema:Periodical
217 sg:person.01010703671.38 schema:affiliation grid-institutes:grid.261445.0
218 schema:familyName Katayama
219 schema:givenName Takako
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010703671.38
221 rdf:type schema:Person
222 sg:person.01014223462.98 schema:affiliation grid-institutes:grid.261445.0
223 schema:familyName Nakamae
224 schema:givenName Hirohisa
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98
226 rdf:type schema:Person
227 sg:person.01045377355.65 schema:affiliation grid-institutes:grid.261445.0
228 schema:familyName Aimoto
229 schema:givenName Mizuki
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045377355.65
231 rdf:type schema:Person
232 sg:person.01061333113.37 schema:affiliation grid-institutes:grid.261445.0
233 schema:familyName Koh
234 schema:givenName Shiro
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061333113.37
236 rdf:type schema:Person
237 sg:person.01102773250.93 schema:affiliation grid-institutes:grid.261445.0
238 schema:familyName Nishimoto
239 schema:givenName Mitsutaka
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102773250.93
241 rdf:type schema:Person
242 sg:person.01151415704.02 schema:affiliation grid-institutes:grid.261445.0
243 schema:familyName Kakeya
244 schema:givenName Hiroshi
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151415704.02
246 rdf:type schema:Person
247 sg:person.01161625755.74 schema:affiliation grid-institutes:grid.261445.0
248 schema:familyName Yoshimura
249 schema:givenName Takuro
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161625755.74
251 rdf:type schema:Person
252 sg:person.01224261751.45 schema:affiliation grid-institutes:grid.261445.0
253 schema:familyName Koh
254 schema:givenName Hideo
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224261751.45
256 rdf:type schema:Person
257 sg:person.01306147013.28 schema:affiliation grid-institutes:grid.261445.0
258 schema:familyName Nanno
259 schema:givenName Satoru
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306147013.28
261 rdf:type schema:Person
262 sg:person.01324645723.81 schema:affiliation grid-institutes:grid.261445.0
263 schema:familyName Nakane
264 schema:givenName Takahiko
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324645723.81
266 rdf:type schema:Person
267 sg:person.01340510351.20 schema:affiliation grid-institutes:grid.261445.0
268 schema:familyName Hirose
269 schema:givenName Asao
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340510351.20
271 rdf:type schema:Person
272 sg:person.01344167555.69 schema:affiliation grid-institutes:grid.261445.0
273 schema:familyName Nakamae
274 schema:givenName Mika
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344167555.69
276 rdf:type schema:Person
277 sg:person.0777264155.36 schema:affiliation grid-institutes:grid.261445.0
278 schema:familyName Okamura
279 schema:givenName Hiroshi
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777264155.36
281 rdf:type schema:Person
282 sg:person.0777446051.79 schema:affiliation grid-institutes:grid.261445.0
283 schema:familyName Hino
284 schema:givenName Masayuki
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777446051.79
286 rdf:type schema:Person
287 sg:pub.10.1007/s00277-002-0584-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1075242439
288 https://doi.org/10.1007/s00277-002-0584-y
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
291 https://doi.org/10.1038/bmt.2012.244
292 rdf:type schema:CreativeWork
293 sg:pub.10.1186/cc10242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027373539
294 https://doi.org/10.1186/cc10242
295 rdf:type schema:CreativeWork
296 grid-institutes:grid.261445.0 schema:alternateName Department of Infection Control Science, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan
297 Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan
298 schema:name Department of Infection Control Science, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan
299 Hematology, Graduate School of Medicine, Osaka City University, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan
300 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...