Detection of opsonic antibodies against Enterococcus faecalis cell wall carbohydrates in immune globulin preparations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08

AUTHORS

M. Hufnagel, K. Sixel, F. Hammer, A. Kropec, I. G. Sava, C. Theilacker, R. Berner, J. Huebner

ABSTRACT

Three different commercially available polyvalent immune globulins (IG) were investigated for the existence of antibodies against cell wall carbohydrates of four different E. faecalis serotypes (using a cell wall carbohydrate-enzyme-linked immunosorbent assay), and whether these antibodies mediated opsonic killing (using an opsonic-killing assay). All three IG preparations contained antibodies against all four serotypes (CPS-A to CPS-D). However, only one of the three IG preparations showed opsonic killing against all four serotypes. Average killing was higher against serotypes A and B (72 and 79 %, respectively) than against serotypes C and D (30 and 37 %, respectively). Such IG preparations could play a role as an adjuvant therapeutic option in life-threatening infections with E. faecalis, particularly when resistant strains are involved. More... »

PAGES

749-755

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s15010-014-0628-y

DOI

http://dx.doi.org/10.1007/s15010-014-0628-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016831352

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24854332


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