Sporopachydermia cereana fungaemia in refractory leukaemia presenting as breakthrough infection during micafungin therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-01-08

AUTHORS

T. S. Y. Chan, Y.-Y. Hwang, K. K. To, Y.-L. Kwong

ABSTRACT

The Sporopachydermia cereana species lives in decaying stems of cactus and is exceptionally rare as a human pathogen. A 57-year-old man with therapy-refractory acute promyelocytic leukaemia developed severe neutropaenia. After about 3 weeks of micafungin used as prophylaxis, he developed high fever, multiple pulmonary nodular infiltrates and a painful leg lesion. Blood culture yielded a yeast which was not identified by the Vitek 2 system. On ITS1-5.8S-ITS2 gene sequencing, the isolate was identified as S. cereana. Antifungal sensitivity by the Etest showed that the minimum inhibitory concentration for fluconazole was 0.75 μg/mL, and for anidulafungin, it was >32 μg/mL. He responded to liposomal amphotericin B but later died of Escherichia coli septicaemia. There were no cactus plants in the vicinity, suggesting that S. cereana might have alternative habitats. More... »

PAGES

715-717

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s15010-012-0402-y

DOI

http://dx.doi.org/10.1007/s15010-012-0402-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053645235

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23297180


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