Use of Fibrates in the Management of Hyperlipidemia in HIV-Infected Patients Receiving HAART View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-01

AUTHORS

L. Calza, R. Manfredi, F. Chiodo

ABSTRACT

BACKGROUND: Despite potent antiretroviral activity, protease inhibitor-based pharmacological treatment of HIV disease has recently been associated with lipid and glucose metabolism abnormalities (more frequently hypertriglyceridemia and hypercholesterolemia). The aim of our open-label, randomized, prospective study was to evaluate the role of fibrates in the management of HIV-associated hyperlipidemia. PATIENTS AND METHODS: Plasma lipid levels of 635 HIV-infected patients referred to our tertiary care center and who had been receiving protease inhibitor-based antiretroviral therapy for at least 12 months were evaluated. All patients presenting hypertriglyceridemia (> 300 mg/dl) of at least 6-month duration and unresponsive to a hypolipidemic diet and physical exercise were treated with bezafibrate (400 mg once daily), gemfibrozil (600 mg twice daily) or fenofibrate (200 mg once daily) for 12 months. RESULTS: 69 (10.9%) of the 635 observed patients received fibrate therapy: bezafibrate was employed in 25 cases, gemfibrozil in 22 and fenofibrate in 22. Hypolipidemic drugs led to a reduction of 41.2% and 23.3% vs baseline triglyceridemia and cholesterolemia, respectively, with a favorable tolerability profile. CONCLUSION: All used fibrates showed a similar, significant efficacy in the treatment of diet-resistant hyperlipidemia, but further studies seem necessary in order to establish the most appropriate guidelines for the management of dyslipidemia associated with highly active antiretroviral therapy (HAART). More... »

PAGES

26-31

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s15010-001-2052-3

DOI

http://dx.doi.org/10.1007/s15010-001-2052-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038493476

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11876511


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