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    "description": "Arzneimittel\u00fcberempfindlichkeitsreaktionen sind unvorhersehbare, durch Arzneimittel hervorgerufene Reaktionen. Sie manifestieren sich entweder innerhalb von ein bis sechs Stunden nach Arzneimittelzufuhr (\u201eSofortreaktionen\u201c) mit geringgradigen bis lebensbedrohlichen Symptomen der Anaphylaxie oder mehrere Stunden bis Tage sp\u00e4ter (\u201eSp\u00e4treaktionen\u201c) vorwiegend als Exantheme. Eine Beteiligung des Immunsystems (Allergie) ist nicht immer nachweisbar. Der Verzicht auf eine Diagnostik kann einerseits schwere Reaktionen bei erneuter Exposition zur Folge haben, andererseits zu ungerechtfertigter Einschr\u00e4nkung der Therapiem\u00f6glichkeiten f\u00fchren. Experten verschiedener Fachgesellschaften und Institutionen haben in dieser Leitlinie Empfehlungen und einen Algorithmus zur Allergiediagnostik erarbeitet. Wesentliche Prinzipien der allergologischen Diagnostik von \u00dcberempfindlichkeitsreaktionen auf Arzneimittel werden dargelegt. Die allergologische Kl\u00e4rung m\u00f6glichst innerhalb von vier Wochen bis sechs Monaten nach der Reaktion ist anzustreben. Eine klinische Zuordnung des Krankheitsbildes anhand von Morphologie und Zeitablauf der Reaktion ist f\u00fcr die Planung der Diagnostik notwendig. Bei typischer Symptomatik einer Arzneimittel\u00fcberempfindlichkeitsreaktion und eindeutigen Befunden validierter Haut- und/oder Labortests kann die Zuordnung zu einem Ausl\u00f6ser als ausreichend angesehen werden. H\u00e4ufig sind jedoch Haut- und Labortests negativ oder nicht sicher aussagekr\u00e4ftig. In diesen F\u00e4llen ist eine kontrollierte Provokationstestung zur Aufkl\u00e4rung der Reaktion erforderlich. Bei Beachtung von Indikationen und Kontraindikationen sowie angemessener \u00e4rztlicher \u00dcberwachung ist sie eine aussagekr\u00e4ftige und sichere Methode. Das Ergebnis der Gesamtbeurteilung wird mit dem Patienten besprochen und in einem Allergiepass dokumentiert, sodass zuk\u00fcnftig eine gezielte Karenz eingehalten werden kann und gegebenenfalls Ausweichmedikamente zur Verf\u00fcgung stehen.", 
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    "name": "Leitlinie Allergologische Diagnostik von \u00dcberempfindlichkeitsreaktionen auf Arzneimittel", 
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