Inhibitory Effect of Topical Cartilage Acellular Matrix Suspension Treatment on Neovascularization in a Rabbit Corneal Model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-07-02

AUTHORS

Hee-Woong Yun, Byung Hyune Choi, Do Young Park, Long Hao Jin, Byoung-Hyun Min

ABSTRACT

Background:The extracellular matrix (ECM) of articular cartilage has an inhibitory effect on vascularization, yet clinical utilization has been technically challenging. In this study, we aimed to fabricate a biologically functional ECM powder suspension from porcine articular cartilage that inhibits neovascularization (NV).Methods:The digested-cartilage acellular matrix (dg-CAM) was prepared by sequential processes of decellularization, enzymatic digestion and pulverization. Physicochemical properties of dg-CAM were compared with that of native cartilage tissue (NCT). Cellular interactions between human umbilical vein endothelial cells (HUVECs) and dg-CAM was evaluated with proliferation, migration and tube formation assays compared with that of type I collagen (COL) and bevacizumab, an anti-angiogenic drug. We then investigated the therapeutic potential of topical administration of dg-CAM suspension on the experimentally induced rabbit corneal NV model.Results:The dg-CAM released a significantly larger amount of soluble proteins than that of the NCT and showed an improved hydrophilic and dispersion properties. In contrast, the dg-CAM contained a large amount of collagen, glycosaminoglycans and anti-angiogenic molecules as much as the NCT. The inhibitory effect on NV of the dg-CAM was more prominent than that of COL and even comparable to that of bevacizumab in inhibiting the HUVECs. The therapeutic potential of the dg-CAM was comparable to that of bevacizumab in the rabbit corneal NV model by efficiently inhibiting neovessel formation of the injured cornea.Conclusion:The current study developed a dg-CAM having anti-angiogenic properties, together with water-dispersible properties suitable for topical or minimally invasive application for prevention of vessel invasion. More... »

PAGES

625-640

References to SciGraph publications

  • 2018-12-08. A Comparative Study of the Effects of Different Decellularization Methods and Genipin-Cross-Linking on the Properties of Tracheal Matrices in TISSUE ENGINEERING AND REGENERATIVE MEDICINE
  • 2017-12-28. Development of Printable Natural Cartilage Matrix Bioink for 3D Printing of Irregular Tissue Shape in TISSUE ENGINEERING AND REGENERATIVE MEDICINE
  • 2011-02-26. Dispersion stability of nanoparticles in ecotoxicological investigations: the need for adequate measurement tools in JOURNAL OF NANOPARTICLE RESEARCH
  • 2012-02-16. Cartilage tissue engineering using chondrocyte-derived extracellular matrix scaffold suppressed vessel invasion during chondrogenesis of mesenchymal stem cells in vivo in TISSUE ENGINEERING AND REGENERATIVE MEDICINE
  • 2000-01. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1 in NATURE MEDICINE
  • 2014-06-02. Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink in NATURE COMMUNICATIONS
  • 2014-05-01. Anti-neovascular effect of chondrocyte-derived extracellular matrix on corneal alkaline burns in rabbits in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 2008-08-01. Improvement of dispersion stability and characterization of upconversion nanophosphors covalently modified with PEG as a fluorescence bioimaging probe in JOURNAL OF MATERIALS SCIENCE
  • 2015-10-25. Effect of decellularization on the load-bearing characteristics of articular cartilage matrix in TISSUE ENGINEERING AND REGENERATIVE MEDICINE
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    http://scigraph.springernature.com/pub.10.1007/s13770-020-00275-3

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    http://dx.doi.org/10.1007/s13770-020-00275-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1128946586

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32617955


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