Oleanolic acid from Fragaria ananassa calyx leads to inhibition of α-MSH-induced melanogenesis in B16-F10 melanoma cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-12

AUTHORS

Sang Keun Han, Yun Gi Kim, Hee Cheol Kang, Jeong Ran Huh, Ji Yeoung Kim, Nam-In Baek, Dong-Kyu Lee, Dong-Geol Lee

ABSTRACT

Natural products with non-toxic and environmentally friendly properties are good sources for skin-whitening and brightening cosmetic agents. Strawberries (Fragaria ananassa), and their parts are used as cosmetic agents, because they contain high levels of bioactive substances. We isolated and identified compounds from F. ananassa calyx. Oleanolic acid has multiple biological activities, including anti-tumor, anti-angiogenic, antiinflammatory, anti-oxidant, and pro-apoptotic effects. However, no study has investigated the influence of oleanolic acid on melanin synthesis in B16-F10 melanoma cells. In the present study, we investigated the effect of oleanolic acid on melanin biosynthesis in B16-F10 melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH). Oleanolic acid-mediated melanogenesis inhibition was studied by measuring intracellular and secreted melanin levels and by using Western blot and semiquantitative reverse transcriptase-polymerase chain reaction analyses. Oleanolic acid suppressed melanin release and expression, resulting in a significant dose-dependent decrease in secreted and intracellular melanin levels and cellular tyrosinase activity. Furthermore, it inhibited the expression of melanogenesis-associated factors, including tyrosinase, tyrosinase-related proteins-1 and -2, and microphthalmia-associated transcription factor, in α-MSH-stimulated B16-F10 melanoma cells. The results of the present study can contribute to the development of cosmetic agents utilizing the skin whitening and brightening effect of oleanolic acid, which will likely have a wide range of applications in the cosmetic industry and/or clinical practice in the future. More... »

PAGES

735-742

References to SciGraph publications

  • 1982-07. New Regulators of Melanogenesis Are Associated with Purified Tyrosinase Isozymes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2000-09. Management of Facial Hyperpigmentation in AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
  • 2014-12. Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells in BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
  • 2007-04. Approaches to Identify Inhibitors of Melanin Biosynthesis via the Quality Control of Tyrosinase in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13765-014-4225-7

    DOI

    http://dx.doi.org/10.1007/s13765-014-4225-7

    DIMENSIONS

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