Gene inactivation study on gntK, a putative C-methyltransferase gene in gentamicin biosynthesis from Micromonospora echinospora View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-06

AUTHORS

Suman Karki, Jin-Yong Kim, Si-Hyung Park, Hyung-Jin Kwon

ABSTRACT

GntK harbors methyltransferase-related cobalamin-binding domain and radical S-adenosylmethionine domain. The gntK-inactivation mutant of Micromonospora echinospora accumulated higher levels of gentamicin Cla and lower levels of gentamicin C1 and C2 isomers compared to the wild-type strain. Based on these results, we propose that GntK is involved in C-methylation on C-6′ in gentamicin X2 but is dispensable in gentamicin biosynthesis. More... »

PAGES

439-442

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13765-012-2041-5

DOI

http://dx.doi.org/10.1007/s13765-012-2041-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052533227


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