Development of IgA vasculitis with severe glomerulonephritis after COVID-19 vaccination: a case report and literature review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-03-11

AUTHORS

Kohei Sugita, Shuzo Kaneko, Rina Hisada, Makiko Harano, Emi Anno, Sou Hagiwara, Eri Imai, Michio Nagata, Yusuke Tsukamoto

ABSTRACT

With the worldwide spread of the COVID-19 vaccine program during the COVID-19 pandemic, the numbers of reported cases with new-onset or relapsed kidney disease/vasculitis such as minimal change nephrotic syndrome, immunoglobulinA (IgA) nephropathy, and IgA vasculitis (IgAV) that developed after COVID-19 vaccination are increasing. We present the case of a 67-year-old Japanese woman who developed IgAV with purpura on her extremities and trunk in the evening of the day that she received the second dose of the Pfizer-BioNTech COVID-19 vaccine. She subsequently presented with acute kidney injury and nephrotic syndrome, and a kidney biopsy performed 14 days after the second vaccination showed diffuse mesangial and endocapillary glomerulonephritis with necrotizing crescent formation, accompanied by IgA deposition. One steroid pulse plus four administrations of a monthly intravenous cyclophosphamide injection were applied, followed by oral azathioprine during oral steroid tapering. Her response to this treatment was unsatisfactory and intractable for some time. Eventually, her renal function improved and nephrotic syndrome was resolved, while microscopic hematuria and proteinuria at ~ 1 g/gCr remained at 6 months post-vaccination. Unlike the previous milder renal-involved IgAV cases following COVID-19 vaccination, our patient’s case presented severe glomerulonephritis and took a long time to recover despite intensive initial immunosuppressive treatment. More... »

PAGES

1-6

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13730-022-00695-1

DOI

http://dx.doi.org/10.1007/s13730-022-00695-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1146214455

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35275366


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