Ontology type: schema:ScholarlyArticle Open Access: True
2021-01-02
AUTHORSTakeshi Tosaki, Masahiro Okabe, Tomo Suzuki, Akihiro Shimizu, Kentaro Koike, Nobuo Tsuboi, Tetsuya Kawamura, Ryuji Ohashi, Shingo Yano, Takashi Yokoo
ABSTRACTIdiopathic multicentric Castleman disease (iMCD) is a systemic lymphoproliferative disease involving multiple organs, including the kidneys. Membranous nephropathy (MN) has been rarely reported as a complication of iMCD. We herein report the case of a 48-year-old man with a 9-year history of iMCD that was complicated by treatment-resistant nephrotic syndrome due to MN. The first renal biopsy performed at the age of 45 years showed diffuse and global MN with a mild glomerular endothelial injury. He was treated with combined therapy of corticosteroids, immunosuppressants, and tocilizumab, an anti-interleukin-6 (IL-6) receptor monoclonal antibody, which was administered every 2–3 weeks. However, nephrotic syndrome persisted, and renal impairment slowly worsened. Serial biopsy performed at 3 years after the first biopsy confirmed advanced lesions of both MN-related and glomerular endothelial injuries. Modification of the therapeutic strategy to weekly administration of tocilizumab gradually led to the remission of proteinuria, allowing the termination of corticosteroids. Thus, the present case suggests a close link between excessive IL-6 actions and the development of glomerular lesions in iMCD. Successful treatment by strict inhibition of IL-6 actions, in this case, may provide a clue for deciding the therapeutic strategy for severe renal complications associated with iMCD. More... »
PAGES265-272
http://scigraph.springernature.com/pub.10.1007/s13730-020-00559-6
DOIhttp://dx.doi.org/10.1007/s13730-020-00559-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1134281228
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/33389670
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Monoclonal, Humanized",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Castleman Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glomerulonephritis, Membranous",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thrombotic Microangiopathies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.411898.d",
"name": [
"Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Tosaki",
"givenName": "Takeshi",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.411898.d",
"name": [
"Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Okabe",
"givenName": "Masahiro",
"id": "sg:person.0662566237.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662566237.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.412764.2",
"name": [
"Department of Nephrology, Kameda Medical Center, Kamogawa, Japan",
"Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Suzuki",
"givenName": "Tomo",
"id": "sg:person.01006223635.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006223635.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.411898.d",
"name": [
"Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Shimizu",
"givenName": "Akihiro",
"id": "sg:person.01131241374.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131241374.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.411898.d",
"name": [
"Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Koike",
"givenName": "Kentaro",
"id": "sg:person.0753403513.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753403513.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.411898.d",
"name": [
"Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Tsuboi",
"givenName": "Nobuo",
"id": "sg:person.01205054154.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205054154.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.411898.d",
"name": [
"Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kawamura",
"givenName": "Tetsuya",
"id": "sg:person.0676043416.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676043416.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Diagnostic Pathology, Nippon Medical School Musashi-Kosugi Hospital, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.459842.6",
"name": [
"Department of Diagnostic Pathology, Nippon Medical School Musashi-Kosugi Hospital, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Ohashi",
"givenName": "Ryuji",
"id": "sg:person.01007566226.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007566226.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.411898.d",
"name": [
"Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Yano",
"givenName": "Shingo",
"id": "sg:person.01265010246.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.411898.d",
"name": [
"Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Yokoo",
"givenName": "Takashi",
"id": "sg:person.01122657316.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122657316.61"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s13730-019-00399-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1113808759",
"https://doi.org/10.1007/s13730-019-00399-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2012.207",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034028134",
"https://doi.org/10.1038/modpathol.2012.207"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13730-020-00511-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1129666802",
"https://doi.org/10.1007/s13730-020-00511-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13730-018-0336-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103995528",
"https://doi.org/10.1007/s13730-018-0336-z"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-01-02",
"datePublishedReg": "2021-01-02",
"description": "Idiopathic multicentric Castleman disease (iMCD) is a systemic lymphoproliferative disease involving multiple organs, including the kidneys. Membranous nephropathy (MN) has been rarely reported as a complication of iMCD. We herein report the case of a 48-year-old man with a 9-year history of iMCD that was complicated by treatment-resistant nephrotic syndrome due to MN. The first renal biopsy performed at the age of 45\u00a0years showed diffuse and global MN with a mild glomerular endothelial injury. He was treated with combined therapy of corticosteroids, immunosuppressants, and tocilizumab, an anti-interleukin-6 (IL-6) receptor monoclonal antibody, which was administered every 2\u20133\u00a0weeks. However, nephrotic syndrome persisted, and renal impairment slowly worsened. Serial biopsy performed at 3\u00a0years after the first biopsy confirmed advanced lesions of both MN-related and glomerular endothelial injuries. Modification of the therapeutic strategy to weekly administration of tocilizumab gradually led to the remission of proteinuria, allowing the termination of corticosteroids. Thus, the present case suggests a close link between excessive IL-6 actions and the development of glomerular lesions in iMCD. Successful treatment by strict inhibition of IL-6 actions, in this case, may provide a clue for deciding the therapeutic strategy for severe renal complications associated with iMCD.",
"genre": "article",
"id": "sg:pub.10.1007/s13730-020-00559-6",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1050419",
"issn": [
"2192-4449"
],
"name": "CEN Case Reports",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "10"
}
],
"keywords": [
"idiopathic multicentric Castleman disease",
"glomerular endothelial injury",
"membranous nephropathy",
"IL-6 action",
"multicentric Castleman's disease",
"endothelial injury",
"nephrotic syndrome",
"Castleman's disease",
"therapeutic strategies",
"thrombotic microangiopathy-like lesions",
"treatment-resistant nephrotic syndrome",
"systemic lymphoproliferative disease",
"therapy of corticosteroids",
"severe renal complications",
"remission of proteinuria",
"first renal biopsy",
"receptor monoclonal antibody",
"renal impairment",
"renal complications",
"weekly administration",
"renal biopsy",
"first biopsy",
"serial biopsies",
"lymphoproliferative disease",
"glomerular lesions",
"successful treatment",
"advanced lesions",
"multiple organs",
"tocilizumab",
"biopsy",
"monoclonal antibodies",
"lesions",
"disease",
"present case",
"corticosteroids",
"nephropathy",
"complications",
"syndrome",
"injury",
"remission",
"proteinuria",
"strict inhibition",
"patients",
"immunosuppressants",
"therapy",
"years",
"kidney",
"administration",
"cases",
"impairment",
"weeks",
"antibodies",
"age",
"men",
"treatment",
"organs",
"inhibition",
"action",
"diffuse",
"history",
"strategies",
"close link",
"termination",
"clues",
"development",
"modification",
"link"
],
"name": "Membranous nephropathy with thrombotic microangiopathy-like lesions successfully treated with tocilizumab in a patient with idiopathic multicentric Castleman disease",
"pagination": "265-272",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1134281228"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s13730-020-00559-6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"33389670"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s13730-020-00559-6",
"https://app.dimensions.ai/details/publication/pub.1134281228"
],
"sdDataset": "articles",
"sdDatePublished": "2022-09-02T16:05",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_881.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s13730-020-00559-6"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13730-020-00559-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13730-020-00559-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13730-020-00559-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13730-020-00559-6'
This table displays all metadata directly associated to this object as RDF triples.
246 TRIPLES
21 PREDICATES
104 URIs
92 LITERALS
15 BLANK NODES