Poststreptococcal acute glomerulonephritis in a girl with renal cell carcinoma: possible pathophysiological association View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-09-20

AUTHORS

Asako Kageyama, Hiroko Fukushima, Joichi Usui, Atsushi Iwabuchi, Ryoko Suzuki, Kouji Masumoto, Takashi Oda, Michio Nagata, Hidetoshi Takada

ABSTRACT

The severity of the poststreptococcal acute glomerulonephritis is considered to be modulated by the immune response of each individual, although there had been few reports regarding specific factors. Renal cell carcinoma is a cancer frequently associated with paraneoplastic syndrome, characterized by fever, leukocytosis, elevated cytokines, and elevated hormone levels. All of these symptoms resolve after tumor resection. A girl with renal cell carcinoma developed renal failure rapidly, which resolved promptly right after nephrectomy for the carcinoma. She was diagnosed as having poststreptococcal acute glomerulonephritis according to the results of pathological and serological examinations. In addition, elevated serum interleukin-6 level before the surgery was detected. Six and a half years after the diagnosis, the patient’s renal function was within normal range and she was tumor free. Because of the quick resolution of her renal dysfunction after the nephrectomy, paraneoplastic syndrome induced by renal cell carcinoma seemed to play a key role in the accentuation of poststreptococcal acute glomerulonephritis. More... »

PAGES

139-144

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13730-020-00526-1

DOI

http://dx.doi.org/10.1007/s13730-020-00526-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131001282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32951174


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