Novel Asp511Thr mutation in McArdle disease with acute kidney injury caused by rhabdomyolysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-21

AUTHORS

Ayaka Satoh, Shuma Hirashio, Takahiro Arima, Yumi Yamada, Taisuke Irifuku, Haruka Ishibashi, Atsuko Motoda, Yoshimasa Sueda, Takao Masaki

ABSTRACT

McArdle disease (glycogen storage disease type V) is a rare hereditary metabolic myopathy. It can be overlooked clinically because it often presents as chronic asymptomatic hypercreatine phosphokinasemia (hyperCKemia). However, vigorous exercise or infections can trigger severe rhabdomyolysis. We present the case of a patient with long-term idiopathic hyperCKemia who, after contracting an upper respiratory tract infection, developed severe rhabdomyolysis and acute kidney injury. Upon hemodialysis, his renal function recovered and CK levels fell to below baseline, and maintenance therapy with vitamin B6 was also started. A molecular diagnosis of McArdle disease was subsequently made. Whole-exome sequencing revealed homozygous c1538delG (p.Asp511Thr fs*28) mutations in the PYGM gene, which was a novel mutation. Therefore, when investigating idiopathic hyperCKemia, glycogen storage disorders should also be considered. More... »

PAGES

1-6

Journal

TITLE

CEN Case Reports

ISSUE

N/A

VOLUME

N/A

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13730-019-00392-6

DOI

http://dx.doi.org/10.1007/s13730-019-00392-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112919071

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30900170


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