Tubulointerstitial nephritis as adverse effect of programmed cell death 1 inhibitor, nivolumab, showed distinct histological findings View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08-28

AUTHORS

Ai Uchida, Maho Watanabe, Aya Nawata, Yosuke Ikari, Masaru Sasaki, Kana Shigemoto, Satoshi Hisano, Hitoshi Nakashima

ABSTRACT

Immune-checkpoint inhibitor nivolumab (anti-PD-1 antibody) blocks T cell inhibition and stimulate immunologic response toward cancer cells. It was also revealed that PD-1/PD-L1 interaction crucially controls the effector differentiation of auto-reactive T cells to maintain self-tolerance. Therefore, potential autoimmunological side-effect can occur in any organ. Here, we report a case of 67-year-old Japanese male with lung adenocarcinoma treated with nivolumab who developed acute tubulointerstitial nephritis after the third infusion of nivolumab. Kidney biopsy showed distinct histological findings: Proliferation of CD38 positive and IgG positive plasma cells, and affluent infiltration of FoxP3+ regulatory T cells. Herein, we do pathological discussion concerning acute tubulointerstitial nephritis occurred in this case based on these histological findings. More... »

PAGES

169-174

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13730-017-0269-y

DOI

http://dx.doi.org/10.1007/s13730-017-0269-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091373529

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28849361


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