Diet and Inflammation in Cognitive Ageing and Alzheimer’s Disease View Full Text


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Article Info

DATE

2019-04-04

AUTHORS

Andrea M. McGrattan, Bernadette McGuinness, Michelle C. McKinley, Frank Kee, Peter Passmore, Jayne V. Woodside, Claire T. McEvoy

ABSTRACT

PURPOSE OF REVIEW: Nutrition is known to modulate the immune system and may alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer's disease (AD) and progression of neurodegeneration. Here, we review the evidence for healthy dietary patterns and age-related cognition and discuss potential neuroinflammatory actions of diet on cognitive function. RECENT FINDINGS: Anti-inflammatory dietary patterns such as the Mediterranean diet (MD) and dietary approaches to stop hypertension (DASH) may be neuroprotective. Several dietary components consumed in the MD and DASH (omega-3 fatty acids, antioxidants and polyphenols) can inhibit neuroinflammation associated with AD. Anti-inflammatory diets may also attenuate neuroinflammation via indirect immune pathways from the gut microbiome and systemic circulation. Diet may influence cognitive ageing via several inflammatory pathways. However, data from human studies are lacking and the exact mechanisms linking diet to cognitive function remain elusive. Further dietary intervention studies are required to investigate diet-associated neurological change from the earliest through to latest stages of cognitive decline. Furthermore, incorporation of neuroimaging measures in intervention studies would advance current understanding of the mechanistic effects of dietary modification on neuroinflammation in the ageing brain. More... »

PAGES

53-65

References to SciGraph publications

  • 2015-05-20. Immune attack: the role of inflammation in Alzheimer disease in NATURE REVIEWS NEUROSCIENCE
  • 2016-04-07. Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study in EUROPEAN JOURNAL OF NUTRITION
  • 2018-04-27. Impact of Flavonoids on Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration in CURRENT NUTRITION REPORTS
  • 2007-01. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms in NATURE REVIEWS NEUROSCIENCE
  • 2015-01-09. Mediterranean diet and cognitive function: The sun project in THE JOURNAL OF NUTRITION, HEALTH & AGING
  • 2014-11-12. Polyunsaturated fatty acids and their metabolites in brain function and disease in NATURE REVIEWS NEUROSCIENCE
  • 2018-10-30. Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing in TRANSLATIONAL PSYCHIATRY
  • 2016-11-18. Molecular Anti-inflammatory Mechanisms of Retinoids and Carotenoids in Alzheimer’s Disease: a Review of Current Evidence in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2018-09-26. Microglia in neurodegeneration in NATURE NEUROSCIENCE
  • 2012-10-02. Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population in TRANSLATIONAL PSYCHIATRY
  • 2015-06-11. A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia in SCIENTIFIC REPORTS
  • 2010-10-30. Inflammation and Alzheimer’s disease in ARCHIVES OF PHARMACAL RESEARCH
  • 2007-07. Positron emission tomography imaging of neuroinflammation in NEUROTHERAPEUTICS
  • 2018-06-23. The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review in MOLECULAR NEUROBIOLOGY
  • 2013-03-18. Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trial in THE JOURNAL OF NUTRITION, HEALTH & AGING
  • 2007. Nutritional Intervention in Brain Aging in INFLAMMATION IN THE PATHOGENESIS OF CHRONIC DISEASES
  • 2017-01-23. Adherence to Mediterranean diet and risk of developing cognitive disorders: An updated systematic review and meta-analysis of prospective cohort studies in SCIENTIFIC REPORTS
  • 2014-01-10. Mediterranean diet and functional indicators among older adults in non-Mediterranean and Mediterranean countries in THE JOURNAL OF NUTRITION, HEALTH & AGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13668-019-0271-4

    DOI

    http://dx.doi.org/10.1007/s13668-019-0271-4

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30949921


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