La troponina ad alta sensibilità in Italia View Full Text


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Article Info

DATE

2018-06-13

AUTHORS

Marco Moretti, Maria Aurora Burgio, Piero Cappelletti, Margherita Morandini, Francesca Veneziani, Lucia Malloggi, Massimiliano Luca Manno, Elisabetta Stenner, Daniela Rubin, Giulio Marino, Deborah Mazzei, Dina Di Maria, Matteo Cassin, Alessio Gamboni, Valentino Miconi, Gianni Antonio Galli

ABSTRACT

Background.This document aims to describe the characteristics on the use of high-sensitivity cardiac troponin (hs-cTn) assays in Italy.Methods.Data was collected with the 4th survey on the use of cardiac biomarkers in Italy conducted in 2017 by the Myocardial Markers Study Group of the Italian Society of Laboratory Medicine and Clinical Pathology (GdS-MM SIPMeL). The items dedicated to hs-cTn explored its diffusion, preanalytical and analytical phases, criteria for set decision limits, control of performance and laboratory-clinical interface.Results.61.5% of Laboratories have introduced hs-cTn in the last 5 years, reaching a total diffusion of 77%. In all cases the change of methodology induced a comparison with the clinicians but only 55% of respondents defined a protocol of use and one third shortened their rule in/out. Among those using hs-cTn, 95% set the decision limit for myocardial injury to the 99° percentile, few structures (22%) differentiate it by variables (age and sex), about 90% of reports apply correctly measurement units. 100% of respondents perform internal quality control (IQC), 90% perform external quality assessment (EQA), the introduction of hs-cTn has a positive impact on the intralaboratory Turnaround Time (TAT) but not on the total TAT.Conclusions.The data collected represents the current state of hs-cTn in Italy. The comparison with the literature indicates that it is necessary to continue working on defining and adapting to guidelines in clinical practice. There are criticisms of intralaboratory performance but the main problem is related to insufficient communication between laboratory and clinic, which constitutes a major limit to the potential improvements that the introduction of hs-cTn could bring to both patients and Health Organization. More... »

PAGES

97-104

References to SciGraph publications

  • 2018-06-20. La IV indagine del GdS MM SIPMeL: i marcatori miocardici di “necrosi” in Italia in LA RIVISTA ITALIANA DELLA MEDICINA DI LABORATORIO - ITALIAN JOURNAL OF LABORATORY MEDICINE
  • 2018-03-22. Troponina cTnT-hs: una questione di genere e di età? Valutazione di limiti decisionali differenziati per genere ed età in una popolazione afferente al Dipartimento di Emergenza in LA RIVISTA ITALIANA DELLA MEDICINA DI LABORATORIO - ITALIAN JOURNAL OF LABORATORY MEDICINE
  • 2017-04-06. High-sensitivity assays for troponin in patients with cardiac disease in NATURE REVIEWS CARDIOLOGY
  • 2014-10-10. Stato dell’arte dei marcatori cardiaci in Italia: la III indagine del GdS MM SIMeL in LA RIVISTA ITALIANA DELLA MEDICINA DI LABORATORIO - ITALIAN JOURNAL OF LABORATORY MEDICINE
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    94 society
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    96 structure
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    98 survey
    99 third
    100 time
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