Reducing radiation dermatitis during ongoing radiation therapy: an innovative film-forming wound dressing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

Amparo Quilis, Jaime Martín, Concepción Rodríguez, Purificación Sánchez, Juan Luis Ribes

ABSTRACT

This multicenter study focuses on the use of a film-forming wound dressing in the form of a gel that can be applied directly to the area affected by radiation dermatitis, especially after skin breakdown. The primary objective of the study was to validate the efficacy of an innovative film-forming wound dressing used as monotherapy in the treatment of radiation dermatitis in patients with RTOG score 2.5 (± 0.5) confirmed by the investigator. Fifty-four patients undergoing radiation therapy for different cancer types and developing radiation dermatitis were recruited in the study; they were treated with the film-forming wound dressing when reaching an RTOG score of 2.5 (± 0.5). The evaluation of radiation dermatitis during ongoing radiation therapy was performed using the RISRAS, which includes investigator-assessed items (erythema, dry desquamation, moist desquamation, necrosis) and patient-assessed items (pain, itch, burning sensation, affection of daily activities). The following study shows a statistically significant clinical improvement (p < 0.05) of the RISRAS score (− 16.9%), as well as of specific clinical outcomes, such as erythema (− 20.6%), pain (− 20.5%), itch (− 22.2%), and burning sensation (−24.7%), after the treatment with the film-forming wound dressing during ongoing radiation therapy. Other radiation dermatitis markers, such as inflammation (− 28.9%) and hydration (26.0%), appeared to be significantly influenced. The use of the innovative film-forming wound dressing for radiation dermatitis treatment shows first time evidence of improving the RISRAS score during ongoing radiation therapy, showing major improvements in patients’ quality of life. More... »

PAGES

255-264

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13566-018-0356-5

DOI

http://dx.doi.org/10.1007/s13566-018-0356-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105740401


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fundaci\u00f3n Instituto Valenciano de Oncolog\u00eda", 
          "id": "https://www.grid.ac/institutes/grid.418082.7", 
          "name": [
            "Fundaci\u00f3n Instituto Valenciano de Oncolog\u00eda, Valencia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quilis", 
        "givenName": "Amparo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario de Fuenlabrada", 
          "id": "https://www.grid.ac/institutes/grid.411242.0", 
          "name": [
            "Hospital Universitario de Fuenlabrada, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00edn", 
        "givenName": "Jaime", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Grupo IMO, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodr\u00edguez", 
        "givenName": "Concepci\u00f3n", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Ruber Internacional", 
          "id": "https://www.grid.ac/institutes/grid.413297.a", 
          "name": [
            "Hospital Ruber Internacional, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00e1nchez", 
        "givenName": "Purificaci\u00f3n", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Catal\u00e0 d'Oncologia", 
          "id": "https://www.grid.ac/institutes/grid.418701.b", 
          "name": [
            "Institut Catal\u00e0 d\u2019Oncologia \u2013 ICO, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ribes", 
        "givenName": "Juan Luis", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.radi.2008.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002171354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(95)00060-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006211514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2354.1999.00153.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008924677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1054/ejon.2001.0145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011126750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2016.01.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017076767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdm400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022934255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2014.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025196427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaad.2005.08.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042688774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12968/bjon.1999.8.19.1305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064788382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12968/ijpn.2015.21.4.187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064817584"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-09", 
    "datePublishedReg": "2018-09-01", 
    "description": "This multicenter study focuses on the use of a film-forming wound dressing in the form of a gel that can be applied directly to the area affected by radiation dermatitis, especially after skin breakdown. The primary objective of the study was to validate the efficacy of an innovative film-forming wound dressing used as monotherapy in the treatment of radiation dermatitis in patients with RTOG score 2.5 (\u00b1 0.5) confirmed by the investigator. Fifty-four patients undergoing radiation therapy for different cancer types and developing radiation dermatitis were recruited in the study; they were treated with the film-forming wound dressing when reaching an RTOG score of 2.5 (\u00b1 0.5). The evaluation of radiation dermatitis during ongoing radiation therapy was performed using the RISRAS, which includes investigator-assessed items (erythema, dry desquamation, moist desquamation, necrosis) and patient-assessed items (pain, itch, burning sensation, affection of daily activities). The following study shows a statistically significant clinical improvement (p < 0.05) of the RISRAS score (\u2212 16.9%), as well as of specific clinical outcomes, such as erythema (\u2212 20.6%), pain (\u2212 20.5%), itch (\u2212 22.2%), and burning sensation (\u221224.7%), after the treatment with the film-forming wound dressing during ongoing radiation therapy. Other radiation dermatitis markers, such as inflammation (\u2212 28.9%) and hydration (26.0%), appeared to be significantly influenced. The use of the innovative film-forming wound dressing for radiation dermatitis treatment shows first time evidence of improving the RISRAS score during ongoing radiation therapy, showing major improvements in patients\u2019 quality of life.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13566-018-0356-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1047354", 
        "issn": [
          "1948-7894", 
          "1948-7908"
        ], 
        "name": "Journal of Radiation Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Reducing radiation dermatitis during ongoing radiation therapy: an innovative film-forming wound dressing", 
    "pagination": "255-264", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c770f6bf696794cd0372978716452d150365b29dca7199cbab9820b262042ee7"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13566-018-0356-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105740401"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13566-018-0356-5", 
      "https://app.dimensions.ai/details/publication/pub.1105740401"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000562.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs13566-018-0356-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13566-018-0356-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13566-018-0356-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13566-018-0356-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13566-018-0356-5'


 

This table displays all metadata directly associated to this object as RDF triples.

125 TRIPLES      21 PREDICATES      37 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13566-018-0356-5 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N30ece1961ec84f709be7ad7c6403cc8f
4 schema:citation https://doi.org/10.1016/0360-3016(95)00060-c
5 https://doi.org/10.1016/j.ijrobp.2016.01.043
6 https://doi.org/10.1016/j.jaad.2005.08.054
7 https://doi.org/10.1016/j.radi.2008.08.002
8 https://doi.org/10.1016/j.radonc.2014.01.005
9 https://doi.org/10.1046/j.1365-2354.1999.00153.x
10 https://doi.org/10.1054/ejon.2001.0145
11 https://doi.org/10.1093/annonc/mdm400
12 https://doi.org/10.12968/bjon.1999.8.19.1305
13 https://doi.org/10.12968/ijpn.2015.21.4.187
14 schema:datePublished 2018-09
15 schema:datePublishedReg 2018-09-01
16 schema:description This multicenter study focuses on the use of a film-forming wound dressing in the form of a gel that can be applied directly to the area affected by radiation dermatitis, especially after skin breakdown. The primary objective of the study was to validate the efficacy of an innovative film-forming wound dressing used as monotherapy in the treatment of radiation dermatitis in patients with RTOG score 2.5 (± 0.5) confirmed by the investigator. Fifty-four patients undergoing radiation therapy for different cancer types and developing radiation dermatitis were recruited in the study; they were treated with the film-forming wound dressing when reaching an RTOG score of 2.5 (± 0.5). The evaluation of radiation dermatitis during ongoing radiation therapy was performed using the RISRAS, which includes investigator-assessed items (erythema, dry desquamation, moist desquamation, necrosis) and patient-assessed items (pain, itch, burning sensation, affection of daily activities). The following study shows a statistically significant clinical improvement (p < 0.05) of the RISRAS score (− 16.9%), as well as of specific clinical outcomes, such as erythema (− 20.6%), pain (− 20.5%), itch (− 22.2%), and burning sensation (−24.7%), after the treatment with the film-forming wound dressing during ongoing radiation therapy. Other radiation dermatitis markers, such as inflammation (− 28.9%) and hydration (26.0%), appeared to be significantly influenced. The use of the innovative film-forming wound dressing for radiation dermatitis treatment shows first time evidence of improving the RISRAS score during ongoing radiation therapy, showing major improvements in patients’ quality of life.
17 schema:genre research_article
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf N08a18562bec74c2bbcea67498f7331cc
21 N210689b8cd87453aae7b908bdeddbc22
22 sg:journal.1047354
23 schema:name Reducing radiation dermatitis during ongoing radiation therapy: an innovative film-forming wound dressing
24 schema:pagination 255-264
25 schema:productId N0a0230ff2ea446a2b47f395327e2752e
26 N13b45683343f4dcbb0afa03721c334d1
27 Nec9b3ac11f324261b0594fc6c7b099bd
28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105740401
29 https://doi.org/10.1007/s13566-018-0356-5
30 schema:sdDatePublished 2019-04-11T02:23
31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
32 schema:sdPublisher N8f65ab781818457382f21817025d6bfe
33 schema:url https://link.springer.com/10.1007%2Fs13566-018-0356-5
34 sgo:license sg:explorer/license/
35 sgo:sdDataset articles
36 rdf:type schema:ScholarlyArticle
37 N052c371dccd64c4fadd31c2a391c8a0b schema:name Grupo IMO, Madrid, Spain
38 rdf:type schema:Organization
39 N08a18562bec74c2bbcea67498f7331cc schema:volumeNumber 7
40 rdf:type schema:PublicationVolume
41 N0a0230ff2ea446a2b47f395327e2752e schema:name doi
42 schema:value 10.1007/s13566-018-0356-5
43 rdf:type schema:PropertyValue
44 N13b45683343f4dcbb0afa03721c334d1 schema:name dimensions_id
45 schema:value pub.1105740401
46 rdf:type schema:PropertyValue
47 N210689b8cd87453aae7b908bdeddbc22 schema:issueNumber 3
48 rdf:type schema:PublicationIssue
49 N30ece1961ec84f709be7ad7c6403cc8f rdf:first Ne8bede09e69947b8b3d50ef5c8e847e7
50 rdf:rest N76457ef3805c4a5a8d32c114cb0ffe7f
51 N4ae53324d6624d54ba1e46e9a3bcab80 schema:affiliation https://www.grid.ac/institutes/grid.411242.0
52 schema:familyName Martín
53 schema:givenName Jaime
54 rdf:type schema:Person
55 N4aef79cae625435e864089d9418cbc88 rdf:first N717f68578da347c1840922be39d10142
56 rdf:rest Nf725201c80214eeeb8652ba4b6431a1b
57 N5b99677013d041049af700b97939d7cd rdf:first Nfd7a55f529b44e2ba2d47b8236592fdb
58 rdf:rest rdf:nil
59 N717f68578da347c1840922be39d10142 schema:affiliation N052c371dccd64c4fadd31c2a391c8a0b
60 schema:familyName Rodríguez
61 schema:givenName Concepción
62 rdf:type schema:Person
63 N76457ef3805c4a5a8d32c114cb0ffe7f rdf:first N4ae53324d6624d54ba1e46e9a3bcab80
64 rdf:rest N4aef79cae625435e864089d9418cbc88
65 N8f65ab781818457382f21817025d6bfe schema:name Springer Nature - SN SciGraph project
66 rdf:type schema:Organization
67 N9f411b5801b64f4f946401ca9cfd4c75 schema:affiliation https://www.grid.ac/institutes/grid.413297.a
68 schema:familyName Sánchez
69 schema:givenName Purificación
70 rdf:type schema:Person
71 Ne8bede09e69947b8b3d50ef5c8e847e7 schema:affiliation https://www.grid.ac/institutes/grid.418082.7
72 schema:familyName Quilis
73 schema:givenName Amparo
74 rdf:type schema:Person
75 Nec9b3ac11f324261b0594fc6c7b099bd schema:name readcube_id
76 schema:value c770f6bf696794cd0372978716452d150365b29dca7199cbab9820b262042ee7
77 rdf:type schema:PropertyValue
78 Nf725201c80214eeeb8652ba4b6431a1b rdf:first N9f411b5801b64f4f946401ca9cfd4c75
79 rdf:rest N5b99677013d041049af700b97939d7cd
80 Nfd7a55f529b44e2ba2d47b8236592fdb schema:affiliation https://www.grid.ac/institutes/grid.418701.b
81 schema:familyName Ribes
82 schema:givenName Juan Luis
83 rdf:type schema:Person
84 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
85 schema:name Medical and Health Sciences
86 rdf:type schema:DefinedTerm
87 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
88 schema:name Clinical Sciences
89 rdf:type schema:DefinedTerm
90 sg:journal.1047354 schema:issn 1948-7894
91 1948-7908
92 schema:name Journal of Radiation Oncology
93 rdf:type schema:Periodical
94 https://doi.org/10.1016/0360-3016(95)00060-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1006211514
95 rdf:type schema:CreativeWork
96 https://doi.org/10.1016/j.ijrobp.2016.01.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017076767
97 rdf:type schema:CreativeWork
98 https://doi.org/10.1016/j.jaad.2005.08.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042688774
99 rdf:type schema:CreativeWork
100 https://doi.org/10.1016/j.radi.2008.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002171354
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1016/j.radonc.2014.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025196427
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1046/j.1365-2354.1999.00153.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008924677
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1054/ejon.2001.0145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011126750
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1093/annonc/mdm400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022934255
109 rdf:type schema:CreativeWork
110 https://doi.org/10.12968/bjon.1999.8.19.1305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064788382
111 rdf:type schema:CreativeWork
112 https://doi.org/10.12968/ijpn.2015.21.4.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064817584
113 rdf:type schema:CreativeWork
114 https://www.grid.ac/institutes/grid.411242.0 schema:alternateName Hospital Universitario de Fuenlabrada
115 schema:name Hospital Universitario de Fuenlabrada, Madrid, Spain
116 rdf:type schema:Organization
117 https://www.grid.ac/institutes/grid.413297.a schema:alternateName Hospital Ruber Internacional
118 schema:name Hospital Ruber Internacional, Madrid, Spain
119 rdf:type schema:Organization
120 https://www.grid.ac/institutes/grid.418082.7 schema:alternateName Fundación Instituto Valenciano de Oncología
121 schema:name Fundación Instituto Valenciano de Oncología, Valencia, Spain
122 rdf:type schema:Organization
123 https://www.grid.ac/institutes/grid.418701.b schema:alternateName Institut Català d'Oncologia
124 schema:name Institut Català d’Oncologia – ICO, Barcelona, Spain
125 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...