Optimizing Anti-Inflammatory and Immunomodulatory Effects of Corticosteroid and Vitamin D Analogue Fixed-Dose Combination Therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09

AUTHORS

Siegfried Segaert, Neil H. Shear, Andrea Chiricozzi, Diamant Thaçi, Jose-Manuel Carrascosa, Helen Young, Vincent Descamps

ABSTRACT

Fixed-dose combination topical therapy with corticosteroid and vitamin D analog provides effective treatment and possible long-term management of psoriasis. The anti-inflammatory and immunomodulatory effects of corticosteroids and vitamin D analogs in treating psoriasis are well investigated; their complementary effects lead to the disruption of the inflammatory feedback loop underlying psoriasis pathogenesis. Recent preclinical data showed that combination therapy is more effective than monotherapies of the active ingredients in preventing activation of resting pro-inflammatory cells, inducing immunomodulation, reducing inflammatory responses by regulating T cell production, and normalizing keratinocytes. The increased understanding of the mechanism of action of fixed-dose combination therapy from preclinical studies is supported by several clinical studies. As the efficacy of topical therapy is correlated with the skin penetration of the active ingredients, new drug delivery systems have been developed. The fixed-dose combination Cal/BD aerosol foam creates a modified supersaturated formulation when applied to the skin, which is maintained for at least 26 h in the laboratory setting. Clinical studies have demonstrated superior efficacy of fixed-dose combination calcipotriol (Cal) 50 µg/g and betamethasone dipropionate (BD) 0.5 mg/g aerosol foam compared with monotherapies of the active ingredients. Furthermore, Cal/BD aerosol foam has shown significantly improved efficacy compared with more traditional formulations, such as Cal/BD ointment and gel, in other studies. Calcipotriol also mitigates risks associated with betamethasone dipropionate and vice versa, resulting in the favorable safety profile observed with fixed-dose combination treatment. Recent data also suggest that fixed-dose combination treatment could provide long-term management of psoriasis, although further clinical investigations are needed. Overall, these data support the value of fixed-dose combination therapy of corticosteroid and vitamin D analog and highlight the added potential of innovative drug delivery for the treatment of psoriasis. FUNDING: LEO Pharma. More... »

PAGES

265-279

References to SciGraph publications

  • 2011-02. Gone but Not Forgotten: Lesional Memory in Psoriatic Skin in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-07. New insights of T cells in the pathogenesis of psoriasis in CELLULAR & MOLECULAR IMMUNOLOGY
  • 2001-04. Calcipotriol Ointment in AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
  • 2014-10. Calcipotriol counteracts betamethasone-induced decrease in extracellular matrix components related to skin atrophy in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1996-06. Epidermal Keratinocyte Production of Interferon-γ Immunoreactive Protein and mRNA Is an Early Event in Allergic Contact Dermatitis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2011-02. Resolved Psoriasis Lesions Retain Expression of a Subset of Disease-Related Genes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2009-09. Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2015-04. Efficacy of an Innovative Aerosol Foam Formulation of Fixed Combination Calcipotriol plus Betamethasone Dipropionate in Patients with Psoriasis Vulgaris in CLINICAL DRUG INVESTIGATION
  • 2011-03. Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2001-07. Supersaturation: Enhancement of Skin Penetration and Permeation of a Lipophilic Drug in PHARMACEUTICAL RESEARCH
  • 2016-09. Supersaturation of Calcipotriene and Betamethasone Dipropionate in a Novel Aerosol Foam Formulation for Topical Treatment of Psoriasis Provides Enhanced Bioavailability of the Active Ingredients in DERMATOLOGY AND THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13555-017-0196-z

    DOI

    http://dx.doi.org/10.1007/s13555-017-0196-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091081715

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28785924


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