Imaging Blood Vessel Morphology in Skin: Dynamic Optical Coherence Tomography as a Novel Potential Diagnostic Tool in Dermatology View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06

AUTHORS

Sandra Schuh, Jon Holmes, Martina Ulrich, Lotte Themstrup, Gregor B. E. Jemec, Nathalie De Carvalho, Giovanni Pellacani, Julia Welzel

ABSTRACT

Conventional optical coherence tomography (OCT) enables the visualization of morphological changes of skin cancer. The use of OCT in the diagnostic investigation and in the therapy decision of non-melanoma skin cancer and other skin changes is already established, and has found its way into routine practice. With the development of speckle-variance OCT, also named dynamic OCT (D-OCT), the vascular architecture and the blood flow of the skin can be displayed in vivo and in 3D. This novel angiographic variant of OCT offers the ability to visualize and measure vessel morphology providing a new insight into healthy, inflammatory and neoplastic skin lesions such as malignant melanoma. This review focuses on the possibilities of using D-OCT on healthy and diseased skin. We suggest and illustrate key diagnostic characteristics by analyzing the initial publications and preliminary unpublished data on vessel morphology and distribution. The potential of D-OCT as a diagnostic tool in dermatology is examined and may give rise to future studies on D-OCT, which are needed to confirm the aforementioned features. More... »

PAGES

187-202

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13555-017-0175-4

DOI

http://dx.doi.org/10.1007/s13555-017-0175-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084037183

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28258554


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