Le DRESS (drug reaction with eosinophilia and systemic symptoms): une synergie médicaments-virus qui peut conduire en réanimation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-05

AUTHORS

V. Descamps, S. Ranger-Rogez, P. Musette, A. Barbaud

ABSTRACT

Le syndrome d’hypersensibilité médicamenteuse ou DRESS (drug reaction with eosinophilia and systemic symptoms) est une toxidermie grave. Il se traduit par l’association d’une fièvre élevée, d’un rash cutané avec oedème du visage, d’une polyadénopathie, d’une éosinophilie et/ou de lymphocytes atypiques. La gravité est liée à la survenue d’atteintes viscérales (hépatite, hémophagocytose, encéphalite, pneumopathie, insuffisance rénale, pancréatite, thyroïdite…) qui peuvent évoluer vers un tableau de défaillance multiviscérale et conduire à un transfert en réanimation. Ce syndrome occupe une place particulière dans les toxidermies. Il s’agit en effet d’un syndrome lié à une réponse immunologique contre des réactivations virales (human herpesvirus 6, human herpesvirus 7, virus Epstein-Barr et cytomégalovirus) induites par la prise de certains médicaments. Le DRESS doit aujourd’hui être considéré comme une maladie virale où certains médicaments jouent un rôle inducteur de réactivations virales sur un terrain prédisposé génétiquement qui reste à identifier. Le DRESS est un modèle d’étude d’un domaine de la médecine encore peu connu: la possible synergie entre médicaments et virus. More... »

PAGES

223

References to SciGraph publications

  • 2007-10. A Complex Interaction Between Drug Allergy and Viral Infection in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13546-011-0253-z

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    DIMENSIONS

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