A computational model of ureteral peristalsis and an investigation into ureteral reflux View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02

AUTHORS

G. Hosseini, C. Ji, D. Xu, M. A. Rezaienia, E. Avital, A. Munjiza, J. J. R. Williams, J. S. A. Green

ABSTRACT

The aim of this study is to create a computational model of the human ureteral system that accurately replicates the peristaltic movement of the ureter for a variety of physiological and pathological functions. The objectives of this research are met using our in-house fluid-structural dynamics code (CgLes-Y code). A realistic peristaltic motion of the ureter is modelled using a novel piecewise linear force model. The urodynamic responses are investigated under two conditions of a healthy and a depressed contraction force. A ureteral pressure during the contraction shows a very good agreement with corresponding clinical data. The results also show a dependency of the wall shear stresses on the contraction velocity and it confirms the presence of a high shear stress at the proximal part of the ureter. Additionally, it is shown that an inefficient lumen contraction can increase the possibility of a continuous reflux during the propagation of peristalsis. More... »

PAGES

117-125

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13534-017-0053-0

DOI

http://dx.doi.org/10.1007/s13534-017-0053-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092750336

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30603196


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