Pharmacogenetics and personalized treatment of type 2 diabetes mellitus View Full Text


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Article Info

DATE

2016-08-16

AUTHORS

Pablo Yang, Verónica Ojeda Heredia, Dante M. Beltramo, Néstor W. Soria

ABSTRACT

Type 2 diabetes mellitus (T2DM) is one of the most prevalent diseases in the world. An important difference in effectiveness and toxicity of hypoglycemic agents has been associated with the presence of genetic variants in people with T2DM. We conducted a literature review up November 2015 by combining keywords type 2 diabetes mellitus, hypoglycemic agents and pharmacogenetics (PKG). Metformin, sulfonylureas, and meglitinide drugs are widely used for the T2DM treatment, although new drugs in combination with metformin are administered. Genetic variants in proteins that function as carriers, channels, or metabolizing enzymes affect both the pharmacokinetics and pharmacodynamics of these agents. Significant progress in T2DM’s pharmacogenetics has been made; however, more studies involving a larger number of patients from different ethnic groups must be done. Furthermore, patients with T2DM generally are complex patients receiving hypolipidemic and hypotensive medications. Drug-drug interaction studies between these drugs must be done to really know the contribution of each polymorphism in drug effectiveness and/or toxicity. More... »

PAGES

508-518

References to SciGraph publications

  • 2014-06-07. Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin in DIABETOLOGIA
  • 2012-10-17. The Effect of Novel Promoter Variants in MATE1 and MATE2 on the Pharmacokinetics and Pharmacodynamics of Metformin in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2009-10-22. The effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in Chinese subjects in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2008-02. Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2 diabetes patients in ACTA PHARMACOLOGICA SINICA
  • 2010-06-04. IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population in ACTA PHARMACOLOGICA SINICA
  • 2004-12-08. Common polymorphisms of the PPAR-γ2 (Pro12Ala) and PGC-1α (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial in DIABETOLOGIA
  • 2004-04. Influence of CYP2C9 and CYP2D6 Polymorphisms on the Pharmacokinetics of Nateglinide in Genotyped Healthy Volunteers in CLINICAL PHARMACOKINETICS
  • 2011-09-28. A Common 5′‐UTR Variant in MATE2‐K Is Associated With Poor Response to Metformin in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2010-03-02. Once-Weekly GLP-1 Agonists: How Do They Differ from Exenatide and Liraglutide? in CURRENT DIABETES REPORTS
  • 2010-12-26. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes in NATURE GENETICS
  • 2010-12-17. Abnormal expression and dysfunction of novel SGLT2 mutations identified in familial renal glucosuria patients in HUMAN GENETICS
  • 2002-11. Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C9*1 heterozygotes in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2012-07-28. Effect of CYP2C9 and SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of nateglinide in healthy Chinese male volunteers in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2010-08-31. Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2007-07-04. Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2010-01-06. KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) Polymorphisms Affect Therapeutic Efficacy of Repaglinide in Chinese Patients With Type 2 Diabetes in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2007-06-27. Cytochrome P450 2C9 *2 and *3 Polymorphisms and the Dose and Effect of Sulfonylurea in Type II Diabetes Mellitus in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2005-06-09. Polymorphic Organic Anion Transporting Polypeptide 1B1 is a Major Determinant of Repaglinide Pharmacokinetics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2013-07-15. The association between the PPARγ2 Pro12Ala polymorphism and nephropathy susceptibility in type 2 diabetes: a meta-analysis based on 9,176 subjects in DIAGNOSTIC PATHOLOGY
  • 2012-11-12. PPAR-γ2 and PTPRD gene polymorphisms influence type 2 diabetes patients' response to pioglitazone in China in ACTA PHARMACOLOGICA SINICA
  • 2013-01-12. Meta-analysis of associations between TCF7L2 polymorphisms and risk of type 2 diabetes mellitus in the Chinese population in BMC MEDICAL GENETICS
  • 2011-02-02. Effects of KCNQ1 Polymorphisms on the Therapeutic Efficacy of Oral Antidiabetic Drugs in Chinese Patients With Type 2 Diabetes in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2002-04. Impact of CYP2C9 amino acid polymorphisms on glyburide kinetics and on the insulin and glucose response in healthy volunteers in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2008-04-09. Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2002-09-11. Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2005-08. Effects of Pro12Ala polymorphism of peroxisome proliferator‐activated receptor γ2 gene on rosiglitazone response in type 2 diabetes in CLINICAL PHARMACOLOGY & THERAPEUTICS
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    32 schema:description Type 2 diabetes mellitus (T2DM) is one of the most prevalent diseases in the world. An important difference in effectiveness and toxicity of hypoglycemic agents has been associated with the presence of genetic variants in people with T2DM. We conducted a literature review up November 2015 by combining keywords type 2 diabetes mellitus, hypoglycemic agents and pharmacogenetics (PKG). Metformin, sulfonylureas, and meglitinide drugs are widely used for the T2DM treatment, although new drugs in combination with metformin are administered. Genetic variants in proteins that function as carriers, channels, or metabolizing enzymes affect both the pharmacokinetics and pharmacodynamics of these agents. Significant progress in T2DM’s pharmacogenetics has been made; however, more studies involving a larger number of patients from different ethnic groups must be done. Furthermore, patients with T2DM generally are complex patients receiving hypolipidemic and hypotensive medications. Drug-drug interaction studies between these drugs must be done to really know the contribution of each polymorphism in drug effectiveness and/or toxicity.
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