Role of PKM2 in directing the metabolic fate of glucose in cancer: a potential therapeutic target View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08

AUTHORS

Gustav van Niekerk, Anna-Mart Engelbrecht

ABSTRACT

BACKGROUND: Many of the hallmarks of cancer are not inherently unique to cancer, but rather represent a re-enactment of normal host responses and activities. A vivid example is aerobic glycolysis ('Warburg effect'), which is used not only by cancer cells but also by normal cells that undergo rapid proliferation. A common feature of this metabolic adaptation is a shift in the expression of pyruvate kinase (PK) isoform M1 to isoform M2. Here, we highlight the key role of PKM2 in shifting cancer metabolism between ATP production and biosynthetic processes. Since anabolic processes are highly energy dependent, the fate of glucose in energy production versus the contribution of carbon in biosynthetic processes needs to be finely synchronised. PKM2 acts to integrate cellular signalling and allosteric regulation of metabolites in order to align metabolic activities with the changing needs of the cell. CONCLUSIONS: The central role of PKM2 in directing the flow of carbon between catabolic (ATP-producing) and anabolic processes provides unique opportunities for extending the therapeutic window of currently available and/or novel anti-neoplastic agents. More... »

PAGES

343-351

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  • Journal

    TITLE

    Cellular Oncology

    ISSUE

    4

    VOLUME

    41

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13402-018-0383-7

    DOI

    http://dx.doi.org/10.1007/s13402-018-0383-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104169970

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29797241


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