Hypoxia-inducible microRNA-488 regulates apoptosis by targeting Bim in osteosarcoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-10

AUTHORS

Chusong Zhou, Wei Tan, Hai Lv, Fei Gao, Jin Sun

ABSTRACT

BACKGROUND: Osteosarcoma is a malignant bone cancer of which the survival rate is still low. One reason for this low survival rate is drug resistance. In the past, it has been shown that microRNAs may play critical roles in osteosarcoma development and drug resistance. The mechanisms by which osteosarcoma cells acquire this resistance have, however, remained largely unknown. Here, we aimed at assessing the role of microRNA-488 in the acquisition of drug resistance by osteosarcoma cells. METHODS: Quantitative RT-PCR was used to measure the expression of microRNA-488 in primary osteosarcoma samples and in osteosarcoma-derived cells, whereas microRNA-488 mimics and inhibitors were used to modify its expression in these cells. Luciferase reporter, Western blotting, cell viability, apoptosis and ChIP assays were used to assess the various effects of modified microRNA-488 expression in osteosarcoma-derived cells. RESULTS: We found that microRNA-488 is over-expressed in primary osteosarcoma tissues and osteosarcoma-derived cells and that hypoxia can induce microRNA-488 expression via binding to the hypoxia response element (HRE) in its promoter. We also found that exogenous over-expression of microRNA-488 promotes the proliferation, reduces the apoptosis and decreases the sensitivity to chemotherapy (doxorubicin) of osteosarcoma cells via direct targeting of the tumor suppressor Bim, which is a mediator of apoptosis. In contrast, we found that transfection of a microRNA-488 inhibitor resulted in an increase in both apoptosis and drug sensitivity, and a decrease in proliferation. CONCLUSIONS: Our data suggest that miRNA-488 may serve as a predictor of response to chemotherapy and as a therapeutic target in human osteosarcomas. More... »

PAGES

463-471

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13402-016-0288-2

DOI

http://dx.doi.org/10.1007/s13402-016-0288-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011959374

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27376839


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bcl-2-Like Protein 11", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin Immunoprecipitation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knockdown Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteosarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Southern Medical University", 
          "id": "https://www.grid.ac/institutes/grid.284723.8", 
          "name": [
            "Department of Bone, Zhujiang Hospital, Southern Medical University, Guangdong Province, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Chusong", 
        "id": "sg:person.01123036003.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123036003.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Bone, The Third People Hospital, Guangdong Province, Huizhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "Wei", 
        "id": "sg:person.011100115321.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011100115321.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Southern Medical University", 
          "id": "https://www.grid.ac/institutes/grid.284723.8", 
          "name": [
            "Department of Bone, Zhujiang Hospital, Southern Medical University, Guangdong Province, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lv", 
        "givenName": "Hai", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Bone, Donghua Hospital, Guangdong Province, Dongguan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "Fei", 
        "id": "sg:person.01305377603.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305377603.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Bone, The Third People Hospital, Guangdong Province, Huizhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Jin", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1081/cnv-100102557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007913345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2015.200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008621950", 
          "https://doi.org/10.1038/cddis.2015.200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2008.00510.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009187010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13402-015-0231-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010303637", 
          "https://doi.org/10.1007/s13402-015-0231-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2010.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011260693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2013.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011640451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.29512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014654546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2014.6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014801462", 
          "https://doi.org/10.1038/cdd.2014.6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/cancers6020860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016145005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021394752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2014.240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021704198", 
          "https://doi.org/10.1038/cddis.2014.240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1423-0127-20-31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025986171", 
          "https://doi.org/10.1186/1423-0127-20-31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13402-014-0176-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025992189", 
          "https://doi.org/10.1007/s13402-014-0176-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pathol.4.110807.092222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027363495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030393477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/21.3.485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031234392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13402-014-0188-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032995763", 
          "https://doi.org/10.1007/s13402-014-0188-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13402-015-0239-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035406762", 
          "https://doi.org/10.1007/s13402-015-0239-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13402-015-0239-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035406762", 
          "https://doi.org/10.1007/s13402-015-0239-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13402-014-0200-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037354631", 
          "https://doi.org/10.1007/s13402-014-0200-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e318208eb35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038006213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2014.03.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038752540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep02038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048494691", 
          "https://doi.org/10.1038/srep02038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/14737140.6.7.1075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049068353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078348163", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-10", 
    "datePublishedReg": "2016-10-01", 
    "description": "BACKGROUND: Osteosarcoma is a malignant bone cancer of which the survival rate is still low. One reason for this low survival rate is drug resistance. In the past, it has been shown that microRNAs may play critical roles in osteosarcoma development and drug resistance. The mechanisms by which osteosarcoma cells acquire this resistance have, however, remained largely unknown. Here, we aimed at assessing the role of microRNA-488 in the acquisition of drug resistance by osteosarcoma cells.\nMETHODS: Quantitative RT-PCR was used to measure the expression of microRNA-488 in primary osteosarcoma samples and in osteosarcoma-derived cells, whereas microRNA-488 mimics and inhibitors were used to modify its expression in these cells. Luciferase reporter, Western blotting, cell viability, apoptosis and ChIP assays were used to assess the various effects of modified microRNA-488 expression in osteosarcoma-derived cells.\nRESULTS: We found that microRNA-488 is over-expressed in primary osteosarcoma tissues and osteosarcoma-derived cells and that hypoxia can induce microRNA-488 expression via binding to the hypoxia response element (HRE) in its promoter. We also found that exogenous over-expression of microRNA-488 promotes the proliferation, reduces the apoptosis and decreases the sensitivity to chemotherapy (doxorubicin) of osteosarcoma cells via direct targeting of the tumor suppressor Bim, which is a mediator of apoptosis. In contrast, we found that transfection of a microRNA-488 inhibitor resulted in an increase in both apoptosis and drug sensitivity, and a decrease in proliferation.\nCONCLUSIONS: Our data suggest that miRNA-488 may serve as a predictor of response to chemotherapy and as a therapeutic target in human osteosarcomas.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13402-016-0288-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1312109", 
        "issn": [
          "2211-3428", 
          "2211-3436"
        ], 
        "name": "Cellular Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "Hypoxia-inducible microRNA-488 regulates apoptosis by targeting Bim in osteosarcoma", 
    "pagination": "463-471", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "38fb26faba076571f0846398c37631e43de6e7fecc7c4afe3814747757e9c662"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27376839"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101552938"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13402-016-0288-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011959374"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13402-016-0288-2", 
      "https://app.dimensions.ai/details/publication/pub.1011959374"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87094_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs13402-016-0288-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13402-016-0288-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13402-016-0288-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13402-016-0288-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13402-016-0288-2'


 

This table displays all metadata directly associated to this object as RDF triples.

230 TRIPLES      21 PREDICATES      65 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13402-016-0288-2 schema:about N16daa28387894ef790c598f8ed81eaf7
2 N2da41c94169c4423aa46cc5fc3bdef65
3 N36997ad454e04d80b6346f76014ce04e
4 N567098dbda0b46b9a5f6dfe9a8b4219f
5 N749f57a9a1614b45ad4fe4e2aa9163d4
6 N7d74a41154de43199257f4803798035d
7 N7d81165b71fe462b9accce3010051f45
8 Naa3013f953124b209ed016e31ab8dce5
9 Nbc1d7b2e7c574a45bd63fe4f660c0bd7
10 Nc0665c2589624e56afc044cbf47c5099
11 Ncd0e321d39b843a190e1c016f57aac0a
12 Ndc152188b584445aad73a92537255e31
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author N9cd2365afe1f4b97886e72a88dee3abe
16 schema:citation sg:pub.10.1007/s13402-014-0176-6
17 sg:pub.10.1007/s13402-014-0188-2
18 sg:pub.10.1007/s13402-014-0200-x
19 sg:pub.10.1007/s13402-015-0231-y
20 sg:pub.10.1007/s13402-015-0239-3
21 sg:pub.10.1038/cdd.2014.6
22 sg:pub.10.1038/cddis.2014.240
23 sg:pub.10.1038/cddis.2015.200
24 sg:pub.10.1038/srep02038
25 sg:pub.10.1186/1423-0127-20-31
26 https://app.dimensions.ai/details/publication/pub.1078348163
27 https://doi.org/10.1002/ijc.25753
28 https://doi.org/10.1002/ijc.29512
29 https://doi.org/10.1016/j.biopsych.2010.10.010
30 https://doi.org/10.1016/j.celrep.2015.02.006
31 https://doi.org/10.1016/j.ctrv.2013.11.006
32 https://doi.org/10.1016/j.febslet.2014.03.037
33 https://doi.org/10.1081/cnv-100102557
34 https://doi.org/10.1093/carcin/21.3.485
35 https://doi.org/10.1097/jto.0b013e318208eb35
36 https://doi.org/10.1111/j.1582-4934.2008.00510.x
37 https://doi.org/10.1146/annurev.pathol.4.110807.092222
38 https://doi.org/10.1586/14737140.6.7.1075
39 https://doi.org/10.3390/cancers6020860
40 schema:datePublished 2016-10
41 schema:datePublishedReg 2016-10-01
42 schema:description BACKGROUND: Osteosarcoma is a malignant bone cancer of which the survival rate is still low. One reason for this low survival rate is drug resistance. In the past, it has been shown that microRNAs may play critical roles in osteosarcoma development and drug resistance. The mechanisms by which osteosarcoma cells acquire this resistance have, however, remained largely unknown. Here, we aimed at assessing the role of microRNA-488 in the acquisition of drug resistance by osteosarcoma cells. METHODS: Quantitative RT-PCR was used to measure the expression of microRNA-488 in primary osteosarcoma samples and in osteosarcoma-derived cells, whereas microRNA-488 mimics and inhibitors were used to modify its expression in these cells. Luciferase reporter, Western blotting, cell viability, apoptosis and ChIP assays were used to assess the various effects of modified microRNA-488 expression in osteosarcoma-derived cells. RESULTS: We found that microRNA-488 is over-expressed in primary osteosarcoma tissues and osteosarcoma-derived cells and that hypoxia can induce microRNA-488 expression via binding to the hypoxia response element (HRE) in its promoter. We also found that exogenous over-expression of microRNA-488 promotes the proliferation, reduces the apoptosis and decreases the sensitivity to chemotherapy (doxorubicin) of osteosarcoma cells via direct targeting of the tumor suppressor Bim, which is a mediator of apoptosis. In contrast, we found that transfection of a microRNA-488 inhibitor resulted in an increase in both apoptosis and drug sensitivity, and a decrease in proliferation. CONCLUSIONS: Our data suggest that miRNA-488 may serve as a predictor of response to chemotherapy and as a therapeutic target in human osteosarcomas.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree false
46 schema:isPartOf N1095422b59bf4885989a0800ddd4d6a0
47 Nef26944a2466463d917da5dda23bbedc
48 sg:journal.1312109
49 schema:name Hypoxia-inducible microRNA-488 regulates apoptosis by targeting Bim in osteosarcoma
50 schema:pagination 463-471
51 schema:productId N61dfb6ffab134cfe880c4d5eac0f8bd6
52 N6d92b584c4444d979a09660db93d9bc0
53 N9437b6df68d843f2ab401c21aa3b6d36
54 Nc47bce7c114b4b41a5e1ba2860074f96
55 Nd5a3242200914b42b4ce3e915ec535c1
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011959374
57 https://doi.org/10.1007/s13402-016-0288-2
58 schema:sdDatePublished 2019-04-11T12:23
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N7276fae318bd458eb6ccbbe3e33adab2
61 schema:url https://link.springer.com/10.1007%2Fs13402-016-0288-2
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N0ececd5b78ad4c29ac614048df9115e4 schema:name Department of Bone, The Third People Hospital, Guangdong Province, Huizhou, China
66 rdf:type schema:Organization
67 N1095422b59bf4885989a0800ddd4d6a0 schema:issueNumber 5
68 rdf:type schema:PublicationIssue
69 N1214be56b6e14ce981db4524352fe478 rdf:first sg:person.01305377603.81
70 rdf:rest Nf847389e37724aed9901b0f94112b87a
71 N123d6d314b484ba8a8924e414f795e08 schema:affiliation Ndadb1b00a9074cf5bc84abb168da6af8
72 schema:familyName Sun
73 schema:givenName Jin
74 rdf:type schema:Person
75 N16daa28387894ef790c598f8ed81eaf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Gene Knockdown Techniques
77 rdf:type schema:DefinedTerm
78 N2da41c94169c4423aa46cc5fc3bdef65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Apoptosis
80 rdf:type schema:DefinedTerm
81 N36997ad454e04d80b6346f76014ce04e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Osteosarcoma
83 rdf:type schema:DefinedTerm
84 N5575db92bdd740e8849185b5f8efd98f schema:affiliation https://www.grid.ac/institutes/grid.284723.8
85 schema:familyName Lv
86 schema:givenName Hai
87 rdf:type schema:Person
88 N567098dbda0b46b9a5f6dfe9a8b4219f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name MicroRNAs
90 rdf:type schema:DefinedTerm
91 N61dfb6ffab134cfe880c4d5eac0f8bd6 schema:name pubmed_id
92 schema:value 27376839
93 rdf:type schema:PropertyValue
94 N68fe0e74aa494d4b9284848cee100f42 rdf:first sg:person.011100115321.22
95 rdf:rest Ne13524cf5aea4f3fb4c7b08d75ce45b8
96 N6cf68e31f00a402793ca57baf49dd093 schema:name Department of Bone, Donghua Hospital, Guangdong Province, Dongguan, China
97 rdf:type schema:Organization
98 N6d92b584c4444d979a09660db93d9bc0 schema:name doi
99 schema:value 10.1007/s13402-016-0288-2
100 rdf:type schema:PropertyValue
101 N7276fae318bd458eb6ccbbe3e33adab2 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N749f57a9a1614b45ad4fe4e2aa9163d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Chromatin Immunoprecipitation
105 rdf:type schema:DefinedTerm
106 N7d74a41154de43199257f4803798035d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Bcl-2-Like Protein 11
108 rdf:type schema:DefinedTerm
109 N7d81165b71fe462b9accce3010051f45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Humans
111 rdf:type schema:DefinedTerm
112 N9437b6df68d843f2ab401c21aa3b6d36 schema:name readcube_id
113 schema:value 38fb26faba076571f0846398c37631e43de6e7fecc7c4afe3814747757e9c662
114 rdf:type schema:PropertyValue
115 N9cd2365afe1f4b97886e72a88dee3abe rdf:first sg:person.01123036003.81
116 rdf:rest N68fe0e74aa494d4b9284848cee100f42
117 Naa3013f953124b209ed016e31ab8dce5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Real-Time Polymerase Chain Reaction
119 rdf:type schema:DefinedTerm
120 Nbc1d7b2e7c574a45bd63fe4f660c0bd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Drug Resistance, Neoplasm
122 rdf:type schema:DefinedTerm
123 Nc0665c2589624e56afc044cbf47c5099 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Bone Neoplasms
125 rdf:type schema:DefinedTerm
126 Nc47bce7c114b4b41a5e1ba2860074f96 schema:name nlm_unique_id
127 schema:value 101552938
128 rdf:type schema:PropertyValue
129 Ncd0e321d39b843a190e1c016f57aac0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cell Line, Tumor
131 rdf:type schema:DefinedTerm
132 Nd5a3242200914b42b4ce3e915ec535c1 schema:name dimensions_id
133 schema:value pub.1011959374
134 rdf:type schema:PropertyValue
135 Ndadb1b00a9074cf5bc84abb168da6af8 schema:name Department of Bone, The Third People Hospital, Guangdong Province, Huizhou, China
136 rdf:type schema:Organization
137 Ndc152188b584445aad73a92537255e31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Blotting, Western
139 rdf:type schema:DefinedTerm
140 Ne13524cf5aea4f3fb4c7b08d75ce45b8 rdf:first N5575db92bdd740e8849185b5f8efd98f
141 rdf:rest N1214be56b6e14ce981db4524352fe478
142 Nef26944a2466463d917da5dda23bbedc schema:volumeNumber 39
143 rdf:type schema:PublicationVolume
144 Nf847389e37724aed9901b0f94112b87a rdf:first N123d6d314b484ba8a8924e414f795e08
145 rdf:rest rdf:nil
146 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
147 schema:name Medical and Health Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
150 schema:name Oncology and Carcinogenesis
151 rdf:type schema:DefinedTerm
152 sg:journal.1312109 schema:issn 2211-3428
153 2211-3436
154 schema:name Cellular Oncology
155 rdf:type schema:Periodical
156 sg:person.011100115321.22 schema:affiliation N0ececd5b78ad4c29ac614048df9115e4
157 schema:familyName Tan
158 schema:givenName Wei
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011100115321.22
160 rdf:type schema:Person
161 sg:person.01123036003.81 schema:affiliation https://www.grid.ac/institutes/grid.284723.8
162 schema:familyName Zhou
163 schema:givenName Chusong
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123036003.81
165 rdf:type schema:Person
166 sg:person.01305377603.81 schema:affiliation N6cf68e31f00a402793ca57baf49dd093
167 schema:familyName Gao
168 schema:givenName Fei
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305377603.81
170 rdf:type schema:Person
171 sg:pub.10.1007/s13402-014-0176-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025992189
172 https://doi.org/10.1007/s13402-014-0176-6
173 rdf:type schema:CreativeWork
174 sg:pub.10.1007/s13402-014-0188-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032995763
175 https://doi.org/10.1007/s13402-014-0188-2
176 rdf:type schema:CreativeWork
177 sg:pub.10.1007/s13402-014-0200-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037354631
178 https://doi.org/10.1007/s13402-014-0200-x
179 rdf:type schema:CreativeWork
180 sg:pub.10.1007/s13402-015-0231-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1010303637
181 https://doi.org/10.1007/s13402-015-0231-y
182 rdf:type schema:CreativeWork
183 sg:pub.10.1007/s13402-015-0239-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035406762
184 https://doi.org/10.1007/s13402-015-0239-3
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/cdd.2014.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014801462
187 https://doi.org/10.1038/cdd.2014.6
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/cddis.2014.240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021704198
190 https://doi.org/10.1038/cddis.2014.240
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/cddis.2015.200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008621950
193 https://doi.org/10.1038/cddis.2015.200
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/srep02038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048494691
196 https://doi.org/10.1038/srep02038
197 rdf:type schema:CreativeWork
198 sg:pub.10.1186/1423-0127-20-31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025986171
199 https://doi.org/10.1186/1423-0127-20-31
200 rdf:type schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1078348163 schema:CreativeWork
202 https://doi.org/10.1002/ijc.25753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030393477
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/ijc.29512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014654546
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.biopsych.2010.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011260693
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.celrep.2015.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021394752
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.ctrv.2013.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011640451
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.febslet.2014.03.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038752540
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1081/cnv-100102557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007913345
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/carcin/21.3.485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031234392
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1097/jto.0b013e318208eb35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038006213
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1111/j.1582-4934.2008.00510.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009187010
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1146/annurev.pathol.4.110807.092222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027363495
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1586/14737140.6.7.1075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049068353
225 rdf:type schema:CreativeWork
226 https://doi.org/10.3390/cancers6020860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016145005
227 rdf:type schema:CreativeWork
228 https://www.grid.ac/institutes/grid.284723.8 schema:alternateName Southern Medical University
229 schema:name Department of Bone, Zhujiang Hospital, Southern Medical University, Guangdong Province, Guangzhou, China
230 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...