NF-κB signaling in cancer stem cells: a promising therapeutic target? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10

AUTHORS

K. Vazquez-Santillan, J. Melendez-Zajgla, L. Jimenez-Hernandez, G. Martínez-Ruiz, V. Maldonado

ABSTRACT

BACKGROUND: Cancer stem cells (CSCs) are regulated by several signaling pathways that ultimately control their maintenance and expansion. NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) forms a protein complex that controls DNA transcription and, as such, plays an important role in proliferation, inflammation, angiogenesis, invasion and metastasis. The NF-κB signaling pathway, which has been found to be constitutively activated in CSCs from a variety of cancers, participates in the maintenance, expansion, proliferation and survival of CSCs. Targeted disruption of this pathway may profoundly impair the adverse phenotype of CSCs and may provide a therapeutic opportunity to remove the CSC fraction. In particular, it may be attractive to use specific NF-κB inhibitors in chronic therapeutic schemes to reduce disease progression. Exceptional low toxicity profiles of these inhibitors are a prerequisite for use in combined treatment regimens and to avoid resistance. CONCLUSION: Although still preliminary, recent evidence shows that such targeted strategies may be useful in adjuvant chemo-preventive settings. More... »

PAGES

327-339

References to SciGraph publications

  • 2015-04. Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes in CELLULAR ONCOLOGY
  • 2013-07. Lung cancer stem cells: a biological and clinical perspective in CELLULAR ONCOLOGY
  • 2013-12. NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype in NATURE COMMUNICATIONS
  • 2013-04. Tumour-microenvironment interactions: role of tumour stroma and proteins produced by cancer-associated fibroblasts in chemotherapy response in CELLULAR ONCOLOGY
  • 2008-08. Regulation of IKKβ by miR-199a affects NF-κB activity in ovarian cancer cells in ONCOGENE
  • 2004-05. The proteasome: a suitable antineoplastic target in NATURE REVIEWS CANCER
  • 2014-12. Apoptosis induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through intrinsic and extrinsic pathways in CELLULAR ONCOLOGY
  • 2007-02. Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-κB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner in CELL DEATH & DIFFERENTIATION
  • 2008-10. NF-κB pathway inhibitors preferentially inhibit breast cancer stem-like cells in BREAST CANCER RESEARCH AND TREATMENT
  • 2005-04. Nuclear factor-κB inhibitors as sensitizers to anticancer drugs in NATURE REVIEWS CANCER
  • 2011-08. Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo in ONCOGENE
  • 2009-07. Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKβ in APOPTOSIS
  • 2010-01. Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells in BRITISH JOURNAL OF CANCER
  • 2005-11. The origin of the cancer stem cell: current controversies and new insights in NATURE REVIEWS CANCER
  • 1999-11. Activators and target genes of Rel/NF-κB transcription factors in ONCOGENE
  • 2005-05. NF-kB in development and progression of human cancer in VIRCHOWS ARCHIV
  • 2001-11. Stem cells, cancer, and cancer stem cells in NATURE
  • 2011-09. Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling in NATURE COMMUNICATIONS
  • 2014-05. An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition in NATURE CELL BIOLOGY
  • 2011-01. A single NFκB system for both canonical and non-canonical signaling in CELL RESEARCH
  • 2013-10. The stem cell markers Oct4A, Nanog and c-Myc are expressed in ascites cells and tumor tissue of ovarian cancer patients in CELLULAR ONCOLOGY
  • 2008-05. Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions in GENOME BIOLOGY
  • 2011-12. Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma in JOURNAL OF NEUROINFLAMMATION
  • 2011-08. Inflammation meets cancer, with NF-κB as the matchmaker in NATURE IMMUNOLOGY
  • 2006-05. Nuclear factor-κB in cancer development and progression in NATURE
  • 2010-11. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer in NATURE
  • 2013-12. Frequency of NFKBIA deletions is low in glioblastomas and skewed in glioblastoma neurospheres in MOLECULAR CANCER
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    http://scigraph.springernature.com/pub.10.1007/s13402-015-0236-6

    DOI

    http://dx.doi.org/10.1007/s13402-015-0236-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052198478

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26318853


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