Differential expression of miR-139, miR-486 and miR-21 in breast cancer patients sub-classified according to lymph node status View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-06

AUTHORS

Lene Rask, Eva Balslev, Rolf Søkilde, Estrid Høgdall, Henrik Flyger, Jens Eriksen, Thomas Litman

ABSTRACT

PURPOSE: Therapeutic decisions in breast cancer are increasingly guided by prognostic and predictive biomarkers. Non-protein-coding microRNAs (miRNAs) have recently been found to be deregulated in breast cancers and, in addition, to be correlated with several clinico-pathological features. One of the most consistently up-regulated miRNAs is miR-21. Here, we specifically searched for differentially expressed miRNAs in high-risk breast cancer patients as compared to low-risk breast cancer patients. In the same patients, we also compared miR-21 expression with the expression of its presumed target PTEN. METHODS: Both microarray and RT-qPCR techniques were used to assess miRNA expression levels in lymph node-positive and -negative human invasive ductal carcinoma tissues. Simultaneously, PTEN protein expression levels were assessed using immunohistochemistry. RESULTS: miR-486-5p and miR-139-5p were found to be down-regulated in patients with lymph node metastases, whereas miR-21 was found to be up-regulated in patients with a positive lymph node status. miR-21 expression levels were found to significantly correlate with tumour size (r = 0.403, p = 0.009; Spearman's rank), whereas no relation was found between miR-21 and PTEN expression levels (Kruskal-Wallis test). CONCLUSION: Down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients. More... »

PAGES

215-227

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13402-014-0176-6

DOI

http://dx.doi.org/10.1007/s13402-014-0176-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025992189

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25027758


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