Over-expression of Her-2 in colorectal cancer tissue, but not in serum, constitutes an independent worse prognostic factor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-07

AUTHORS

Sang-Woo Lim, Hye-Ran Kim, Hwan-Young Kim, Jung-Wook Huh, Young-Jin Kim, Jong-Hee Shin, Soon-Pal Suh, Dong-Wook Ryang, Hyeong-Rok Kim, Myung-Geun Shin

ABSTRACT

BACKGROUND: Currently, conflicting information exists regarding Her-2 over-expression and its clinicopathological implications in colorectal cancer (CRC). This study was undertaken to determine Her-2 over-expression in both serum and tumor tissue of CRC patients, and to assess its clinicopathological and targeted therapeutic implications. METHODS: Ninety five CRC patients and sixty healthy controls were prospectively enrolled. Her-2 expression status in serum and CRC tissue were examined by chemiluminescent immunoassay and immunohistochemical staining, respectively. The results were confirmed using fluorescent in situ hybridization. Clinicopathological parameters were analyzed according to Her-2 expression status. RESULTS: Serum Her-2 levels were found to be increased in CRC patients as compared to those of healthy controls. However, serum Her-2 levels were not found to be significantly associated with prognostic parameters. Her-2 expression analysis of CRC tissues revealed Her-2 over-expression in 23 patients (25%), i.e., 13 patients (14%) showed moderate over-expression and 10 patients (11%) showed strong over-expression. The overall survival of patients negative for Her-2 expression was significantly better than that of patients positive for Her-2 expression (P=0.018). The disease-free survival of patients with Her-2 over-expression was significantly shorter than that of patients with no Her-2 expression (P=0.021). CONCLUSIONS: Her-2 over-expression in CRC tissue, but not in serum, acts as a significant independent worse prognostic factor. Assessment of Her-2 expression status may be valuable for the targeted therapeutic management of CRC. More... »

PAGES

311-321

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13402-013-0136-6

DOI

http://dx.doi.org/10.1007/s13402-013-0136-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034364483

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23722824


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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13402-013-0136-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13402-013-0136-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13402-013-0136-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13402-013-0136-6'


 

This table displays all metadata directly associated to this object as RDF triples.

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