Synthesis of Biogenic Chitosan Biopolymer-Functionalized Zinc-Doped Bi2O3 Nanoneedles and Its Bio-applications: In Vitro Antibacterial and Anticancer activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-01-03

AUTHORS

R. Karthik, K. Pandiselvi, K. Mariyappan, K. Park, IS Kwak, J. Sivakamavalli

ABSTRACT

A new biogenic chitosan biopolymer-functionalized zinc-doped bismuth oxide nanoneedle was successfully synthesized by an ultrasound-assisted chemical precipitation method that annealed at 250°C. In this process, an appropriate amount of chitosan, Bi (NO3)2, sodium hydroxide and varying molar ratios of Zn (NO3)2 were used as the source materials. The obtained materials were subjected to annealing at 250°C and then characterized with X-ray diffraction, Fourier transform infrared spectroscopy, high-resolution scanning electron microscope, transmittance electron microscope, and UV–Vis–NIR spectroscopy (UV–Vis–NIR). The electrochemical properties of the materials were investigated by electrochemical impedance spectroscopy, and cyclic voltammetry in the pH range is 4 with (0.1) M buffer solution. Finally, the potential toxicity and antibacterial activity of the materials were investigated against Staphylococcus aureus, Escherichia coli and cancer cell lines HepG2 and C3A. The result indicates that CS/Zn0.75Bi2O3 nanoneedle shows zones of inhibition against S. aureus as 32 mm and E. coli as 35 mm. In the anticancer analysis, CS/Zn0.75Bi2O3 nanoneedles showed a maximum cell inhibition of 65.45% at 100 μg/mL−1. More... »

PAGES

5605-5618

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13369-020-05099-w

DOI

http://dx.doi.org/10.1007/s13369-020-05099-w

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