JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital of Clinics of the Medical School, S\u00e3o Paulo, S\u00e3o Paulo, Brazil", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Laboratory of Medical Investigation LIM 56, Division of Dermatology, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil", 
            "Hospital of Clinics of the Medical School, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferreira", 
        "givenName": "Claudete M. S.", 
        "id": "sg:person.013544266343.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013544266343.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Medical Investigation LIM 56, Division of Dermatology, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Laboratory of Medical Investigation LIM 56, Division of Dermatology, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sunada", 
        "givenName": "Noemia M. O.", 
        "id": "sg:person.014341646743.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014341646743.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Tropical Medicine of Sao Paulo/Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. En\u00e9as de Carvalho Aguiar, 500, Pr\u00e9dio 2, Terceiro Andar, Sao Paulo, SP, Brasil", 
          "id": "http://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Laboratory of Medical Investigation LIM 56, Division of Dermatology, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil", 
            "Hospital of Clinics of the Medical School, S\u00e3o Paulo, S\u00e3o Paulo, Brazil", 
            "Institute of Tropical Medicine of Sao Paulo/Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. En\u00e9as de Carvalho Aguiar, 500, Pr\u00e9dio 2, Terceiro Andar, Sao Paulo, SP, Brasil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casseb", 
        "givenName": "Jorge", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1080/13550280290101094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058383185", 
          "https://doi.org/10.1080/13550280290101094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-017-8503-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085737049", 
          "https://doi.org/10.1007/s00415-017-8503-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-05-08", 
    "datePublishedReg": "2022-05-08", 
    "description": "Abstract\nDespite immune-reconstitution, after TARc HIV-positive patients, neurocognitive disorders related to HIV-1 (HAND) have been observed in these patients. The diagnosis occurs, in most cases, in the advanced stage. The objective of this study is to quantify activation markers (CD25, CD38, CD69, and HLA-DR) in the blood of patients with chronic HIV-1 infection and relate to HAND and premature senescence. The level of activation markers was quantified in the blood of 10 HIV-positive patients with HAND, 10 cases without HAND undergoing regular follow-up at the Secondary Immunodeficiency Clinic (ADEE3002) at the Hospital of Clinics of the Medical School of S\u00e3o Paulo, and 10 healthy seronegative volunteers using the flow cytometry method. Subsequently, the analysis was performed using the FlowJo\u2122 v10.6.1 program and GraphPad Prism 8.3.0. In addition to T CD4+ cells, T CD4+ bright/CD8+ dim and T CD4+/CD8+/CD45RA\u2212/CD27 cells, a specific HIV-1 phenotype, also proved to be relevant to differentiate patients with HAND. Between the activation marker, CD38 in T CD4+ and T CD4+/CD8+/CD45RA\u2212/CD27+ cells and the activation marker HLA-DR in T CD8+/CD45RA\u2212/CD27+ managed to differentiate our HAND group. Importantly, only non-stimulated peripheral blood mononuclear cells (PBMCs) were used in this study. A combination of activation and senescence markers CD38 and HLA-DR and subgroups of T lymphocytes can be used to indicate seropositive patients who are progressing to a HAND condition. Thus, it can contribute to an early diagnosis and opportunity for possible reversal of dementia with alternative treatments, with high penetration in the blood\u2013brain barrier.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s13365-022-01075-2", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.9069071", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1114176", 
        "issn": [
          "1355-0284", 
          "1538-2443"
        ], 
        "name": "Journal of NeuroVirology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }
    ], 
    "keywords": [
      "peripheral blood mononuclear cells", 
      "HIV-positive patients", 
      "activation markers", 
      "T CD4", 
      "HLA-DR", 
      "neurocognitive disorders", 
      "non-stimulated peripheral blood mononuclear cells", 
      "chronic HIV-1 infection", 
      "T-lymphocyte activation markers", 
      "HIV-1-associated neurocognitive disorders", 
      "activation markers HLA-DR", 
      "markers HLA-DR", 
      "HIV-1 infection", 
      "HIV-1 phenotype", 
      "blood mononuclear cells", 
      "blood-brain barrier", 
      "blood of patients", 
      "Hospital of Clinics", 
      "Immunodeficiency Clinic", 
      "seropositive patients", 
      "seronegative volunteers", 
      "flow cytometry method", 
      "mononuclear cells", 
      "T lymphocytes", 
      "HIV-1", 
      "early diagnosis", 
      "alternative treatment", 
      "patients", 
      "advanced stage", 
      "hand group", 
      "CD4", 
      "hand conditions", 
      "cytometry method", 
      "clinic", 
      "CD38", 
      "markers", 
      "diagnosis", 
      "blood", 
      "premature senescence", 
      "disorders", 
      "cells", 
      "combination of activation", 
      "possible reversal", 
      "most cases", 
      "CD8", 
      "medical schools", 
      "hospital", 
      "lymphocytes", 
      "dementia", 
      "infection", 
      "volunteers", 
      "subgroups", 
      "treatment", 
      "FlowJo", 
      "cases", 
      "S\u00e3o Paulo", 
      "study", 
      "activation", 
      "phenotype", 
      "group", 
      "hand", 
      "levels", 
      "senescence", 
      "reversal", 
      "objective", 
      "barriers", 
      "Paulo", 
      "DIM", 
      "program", 
      "stage", 
      "combination", 
      "addition", 
      "analysis", 
      "penetration", 
      "schools", 
      "conditions", 
      "opportunities", 
      "method", 
      "high penetration"
    ], 
    "name": "T-lymphocyte activation markers in patients with HIV-1-associated neurocognitive disorder", 
    "pagination": "1-6", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1147729132"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13365-022-01075-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35527311"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13365-022-01075-2", 
      "https://app.dimensions.ai/details/publication/pub.1147729132"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_927.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s13365-022-01075-2"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

165 TRIPLES      22 PREDICATES      105 URIs      95 LITERALS      5 BLANK NODES