Sequential treatment of progressive multifocal leukoencephalopathy with intravenous immunoglobulins and pembrolizumab View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-03-23

AUTHORS

Fabian Boesl, Kristina Allers, Juliane Herm, Thomas Scheider, Christiana Franke

ABSTRACT

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the CNS caused by the human polyomavirus 2 (JCV). PML predominantly occurs in immunocompromised patients. To date, no specific antiviral treatment exists, leaving only restoration of the immune system as possible treatment. In 2019, the monoclonal antibody pembrolizumab was reported as a potential treatment option in PML in a case series. Following case reports could not thoroughly confirm a positive outcome. Pembrolizumab targets the inhibitory programmed cell death protein 1 (PD-1) receptor on lymphocytes and is associated with beneficial expansion of pre-existing virus-specific T cells. Here we describe a patient with PML who benefited from combined treatment with intravenous immunoglobulins, maraviroc, and pembrolizumab. More... »

PAGES

1-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13365-022-01059-2

DOI

http://dx.doi.org/10.1007/s13365-022-01059-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1146521274

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35320511


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