Changing clinical phenotypes of HIV-associated neurocognitive disorders View Full Text


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Article Info

DATE

2018-04

AUTHORS

Ned Sacktor

ABSTRACT

HIV-associated neurocognitive disorder (HAND) remains a common cause of cognitive impairment and persists in 15-55% of HIV+ individuals in the combination antiretroviral therapy (CART) era. CART is now the primary treatment for HAND, but it is effective in only a subset of patients. In the pre-CART era, HIV-associated dementia was the most common form of HAND. However, in CART-treated patients, the prevalence of HIV-associated dementia has declined substantially, and milder stages of HAND, i.e., ANI and MND predominate. HIV+ patients with mild neurocognitive disorder (MND) can still have significant functional impairment in some activities of daily living. There have been several other significant changes in the clinical features of HAND in the CART era. The mean survival for an individual diagnosed with HIV dementia has increased dramatically. In HIV+ individuals on CART with a suppressed systemic viral load, the majority of individuals with HAND remain stable, with a small proportion showing deterioration. Extrapyramidal signs are now less common in patients with HAND on CART. In the CART era, HAND may have a mixed pattern of both cortical and subcortical features with greater deficits in executive functioning and working memory. Despite the milder clinical phenotype, in the CART era, patients with HAND still have persistent laboratory and neuroimaging abnormalities in the central nervous system even with systemic viral suppression. As the HIV+ patient population ages, cerebrovascular disease risk factors such as hypertension, diabetes, and hypercholesterolemia are increasingly recognized as risk factors for cognitive impairment in HIV+ patients on CART. HAND remains a common neurological condition globally in the CART era, necessitating the need for new animal models to examine pathogenesis and potential treatments for HAND. More... »

PAGES

141-145

References to SciGraph publications

  • 2010-12. Neurocognitive impairment among HIV-positive individuals in Botswana: a pilot study in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
  • 2012-06. Clinical features and preliminary studies of virological correlates of neurocognitive impairment among HIV-infected individuals in Nigeria in JOURNAL OF NEUROVIROLOGY
  • 2016-05. HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment in NATURE REVIEWS NEUROLOGY
  • 2016-06. Cognitive Impairment Among Older Individuals with HIV Infection in CURRENT GERIATRICS REPORTS
  • 2011-06. Subcortical brain atrophy persists even in HAART-regulated HIV disease in BRAIN IMAGING AND BEHAVIOR
  • 2010-12. Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection in AIDS RESEARCH AND THERAPY
  • 2012-02. Factors affecting brain structure in men with HIV disease in the post-HAART era in NEURORADIOLOGY
  • 2011-08. Characterization of HIV-Associated Neurocognitive Disorders Among Individuals Starting Antiretroviral Therapy in South Africa in AIDS AND BEHAVIOR
  • 2010-11. Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus in JOURNAL OF NEUROVIROLOGY
  • 2014-08. Neurocognitive impairment associated with predominantly early stage HIV infection in Abuja, Nigeria in JOURNAL OF NEUROVIROLOGY
  • 2010-12. HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon in BMC NEUROLOGY
  • 2011-02. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors in JOURNAL OF NEUROVIROLOGY
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    http://scigraph.springernature.com/pub.10.1007/s13365-017-0556-6

    DOI

    http://dx.doi.org/10.1007/s13365-017-0556-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090913438

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28752495


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