Identification of putative biomarkers for HIV-associated neurocognitive impairment in the CSF of HIV-infected patients under cART therapy determined by mass ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10

AUTHORS

Adriana Bora, Ceereena Ubaida Mohien, Raghothama Chaerkady, Linda Chang, Richard 4th Moxley, Ned Sacktor, Norman Haughey, Justin C. McArthur, Robert Cotter, Avindra Nath, David R. Graham

ABSTRACT

We identified and measured proteins in the cerebral spinal fluid (CSF) involved in HIV-associated neurological disorders. Protein levels were determined by mass spectrometry (MS) in pooled CSF taken from three patient groups (human immunodeficiency virus (HIV)-1-infected patients that developed HIV-associated neurocognitive disorders (HANDs), HIV-1-infected patients without HAND, and healthy controls). Pools were generated from 10 patients each per group. CSF from individual patient groups were digested with trypsin and separately labeled using with isobaric tags for relative and absolute quantitation (iTRAQ). After combining all samples in one, peptides were extensively fractionated by offline two-dimensional separation and identified by tandem MS. One hundred and ninety three proteins were deemed to be interpretable for quantitation based on permutation tests with a 95 % confidence interval with a p value ≤ 0.05. Using a cutoff of 1.5-fold for upregulation and 0.6 for downregulation, 16 proteins were differentially expressed in HIV + HAND (reporter p value ≤0.05) with seven of them previously described as HIV-interacting proteins: endoplasmin, mitochondrial damage mediator-BH3-interacting domanin death agonist, orosomucoid, apolipoprotein E, metalloproteinase inhibitor 2, peroxiredoxin-2, and the nuclear protein, ruvB-like 2. Several previously unidentified proteins with possible neurological implication in HIV patients include forming-binding protein 1, C-reactive protein, leukocyte-associated immunoglobulin receptor 1, renin receptor, mediator of RNA polymerase II transcription subunit 14, multimerin-2, alpha-N-acetylglucosaminidase, caldesmon, and cadherin EGF LAG G-type receptor. Our results suggest that not only a few but possibly a combination of biomarkers that are highly correlated can predict neurocognitive status in HIV-infected patients and might be involved in monocyte or macrophage activation. More... »

PAGES

457-465

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13365-014-0263-5

DOI

http://dx.doi.org/10.1007/s13365-014-0263-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026890024

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25056907


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AIDS Dementia Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Retroviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, Liquid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mass Spectrometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Hawaii at Manoa", 
          "id": "https://www.grid.ac/institutes/grid.410445.0", 
          "name": [
            "Department of Molecular and Comparative Pathobiology-Retrovirus Laboratory, Baltimore, USA", 
            "Department of Neurology, University of Hawaii, Honolulu, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bora", 
        "givenName": "Adriana", 
        "id": "sg:person.01266611216.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266611216.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Molecular and Comparative Pathobiology-Retrovirus Laboratory, Baltimore, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohien", 
        "givenName": "Ceereena Ubaida", 
        "id": "sg:person.013471461443.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013471461443.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Johns Hopkins School of Medicine, Johns Hopkins University School of Medicine Mass Spectrometry and Proteomics Core, Baltimore, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chaerkady", 
        "givenName": "Raghothama", 
        "id": "sg:person.01360101162.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360101162.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Hawaii at Manoa", 
          "id": "https://www.grid.ac/institutes/grid.410445.0", 
          "name": [
            "Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Linda", 
        "id": "sg:person.016455532612.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016455532612.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Hawaii at Manoa", 
          "id": "https://www.grid.ac/institutes/grid.410445.0", 
          "name": [
            "Department of Neurology, University of Hawaii, Honolulu, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "4th Moxley", 
        "givenName": "Richard", 
        "id": "sg:person.0715170253.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715170253.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Hawaii at Manoa", 
          "id": "https://www.grid.ac/institutes/grid.410445.0", 
          "name": [
            "Department of Neurology, University of Hawaii, Honolulu, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sacktor", 
        "givenName": "Ned", 
        "id": "sg:person.01064501570.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064501570.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Hawaii at Manoa", 
          "id": "https://www.grid.ac/institutes/grid.410445.0", 
          "name": [
            "Department of Neurology, University of Hawaii, Honolulu, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haughey", 
        "givenName": "Norman", 
        "id": "sg:person.01327222362.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327222362.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Hawaii at Manoa", 
          "id": "https://www.grid.ac/institutes/grid.410445.0", 
          "name": [
            "Department of Neurology, University of Hawaii, Honolulu, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McArthur", 
        "givenName": "Justin C.", 
        "id": "sg:person.013000215777.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013000215777.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cotter", 
        "givenName": "Robert", 
        "id": "sg:person.01022060752.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022060752.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Neurological Disorders and Stroke", 
          "id": "https://www.grid.ac/institutes/grid.416870.c", 
          "name": [
            "National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nath", 
        "givenName": "Avindra", 
        "id": "sg:person.011644322237.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011644322237.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Molecular and Comparative Pathobiology-Retrovirus Laboratory, Baltimore, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graham", 
        "givenName": "David R.", 
        "id": "sg:person.01167642705.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167642705.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001962835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200600026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003466251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2012.03.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007394444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac100890k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009696282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac100890k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009696282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1220484110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010731684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200900433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011646497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200900433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011646497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10715762.2013.804622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012977505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/09537100701832157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013095407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mri.2010.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013814387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mvr.2006.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014948667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac0341261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015001215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac0341261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015001215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3283437f9a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017929126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3283437f9a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017929126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.20182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018025544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4690-6-47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018953195", 
          "https://doi.org/10.1186/1742-4690-6-47"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.200410336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022459243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.200410336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022459243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jxb/erj168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023550700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr900634c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024191701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-8-214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027948489", 
          "https://doi.org/10.1186/1471-2105-8-214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2006.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028132174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/82199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030025933", 
          "https://doi.org/10.1038/82199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac025747h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030226321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac025747h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030226321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/appy.12078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033134813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.108.127258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035341665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.108.127258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035341665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.12.10.2934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036874489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-013-9491-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037242959", 
          "https://doi.org/10.1007/s11481-013-9491-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-013-9491-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037242959", 
          "https://doi.org/10.1007/s11481-013-9491-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-013-9491-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037242959", 
          "https://doi.org/10.1007/s11481-013-9491-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gps.3988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037321759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00731863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037537475", 
          "https://doi.org/10.1007/bf00731863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00731863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037537475", 
          "https://doi.org/10.1007/bf00731863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.61.11.1687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038251916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/hsz-2012-0168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038542808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m800029-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038596672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-6-145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038672944", 
          "https://doi.org/10.1186/1471-2164-6-145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m900628-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041317213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2007.04609.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042193376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044651444", 
          "https://doi.org/10.1038/sj.cdd.4401094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044651444", 
          "https://doi.org/10.1038/sj.cdd.4401094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-013-9444-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048753101", 
          "https://doi.org/10.1007/s11481-013-9444-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-013-9444-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048753101", 
          "https://doi.org/10.1007/s11481-013-9444-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr300414z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050502049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.201000722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050706300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0021-9673(00)94785-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050898252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328337b0ab", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051839606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328337b0ab", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051839606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328337b0ab", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051839606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr1009178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052618678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-394592-1.00010-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053262000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm300180r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr050405o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056290880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr050455t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056290912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr060132c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056291064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr060474i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056291257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr2001308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056292522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr300624g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056293128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr300918r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056293244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr900685u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056295085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3560121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056715465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/omi.2011.0004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059303882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000287431.88658.8b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000287431.88658.8b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000287431.88658.8b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077527227", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078628365", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082862586", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082940601", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083104309", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-10", 
    "datePublishedReg": "2014-10-01", 
    "description": "We identified and measured proteins in the cerebral spinal fluid (CSF) involved in HIV-associated neurological disorders. Protein levels were determined by mass spectrometry (MS) in pooled CSF taken from three patient groups (human immunodeficiency virus (HIV)-1-infected patients that developed HIV-associated neurocognitive disorders (HANDs), HIV-1-infected patients without HAND, and healthy controls). Pools were generated from 10 patients each per group. CSF from individual patient groups were digested with trypsin and separately labeled using with isobaric tags for relative and absolute quantitation (iTRAQ). After combining all samples in one, peptides were extensively fractionated by offline two-dimensional separation and identified by tandem MS. One hundred and ninety three proteins were deemed to be interpretable for quantitation based on permutation tests with a 95 % confidence interval with a p value\u2009\u2264\u20090.05. Using a cutoff of 1.5-fold for upregulation and 0.6 for downregulation, 16 proteins were differentially expressed in HIV\u2009+\u2009HAND (reporter p value \u22640.05) with seven of them previously described as HIV-interacting proteins: endoplasmin, mitochondrial damage mediator-BH3-interacting domanin death agonist, orosomucoid, apolipoprotein E, metalloproteinase inhibitor 2, peroxiredoxin-2, and the nuclear protein, ruvB-like 2. Several previously unidentified proteins with possible neurological implication in HIV patients include forming-binding protein 1, C-reactive protein, leukocyte-associated immunoglobulin receptor 1, renin receptor, mediator of RNA polymerase II transcription subunit 14, multimerin-2, alpha-N-acetylglucosaminidase, caldesmon, and cadherin EGF LAG G-type receptor. Our results suggest that not only a few but possibly a combination of biomarkers that are highly correlated can predict neurocognitive status in HIV-infected patients and might be involved in monocyte or macrophage activation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13365-014-0263-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2439410", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2726338", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2345429", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1114176", 
        "issn": [
          "1355-0284", 
          "1538-2443"
        ], 
        "name": "Journal of NeuroVirology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Identification of putative biomarkers for HIV-associated neurocognitive impairment in the CSF of HIV-infected patients under cART therapy determined by mass spectrometry", 
    "pagination": "457-465", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "80195ef10f5cf2e21e2d229306515eaebd53125f90cf24100377d1fca82e42f4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25056907"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9508123"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13365-014-0263-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026890024"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13365-014-0263-5", 
      "https://app.dimensions.ai/details/publication/pub.1026890024"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs13365-014-0263-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13365-014-0263-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13365-014-0263-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13365-014-0263-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13365-014-0263-5'


 

This table displays all metadata directly associated to this object as RDF triples.

375 TRIPLES      21 PREDICATES      97 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13365-014-0263-5 schema:about N33fbd8e08c8847f79857b736be886f3e
2 N3e3b92a7852d4136a5415c8fc7f270b9
3 N45616c05d8de4dd5b315ef155d320410
4 N6a13a4a628fc4045aafe871e886fb6fd
5 Nbb14aa1d56d04c9ebba27f73ff524915
6 Nc8297b59ddf44558a962d927cf75f5b4
7 Ndb4966a40b924c67af65f77fbf8763bc
8 Ndb63cf72ba5146baa815eb120ed80385
9 Ndc75ffdf0b5b46b59602d1bb49c05a87
10 Ne375517021a742d48d0707a59e7003cc
11 anzsrc-for:06
12 anzsrc-for:0601
13 schema:author N8374185994724b0383ff06aab79e878c
14 schema:citation sg:pub.10.1007/bf00731863
15 sg:pub.10.1007/s11481-013-9444-x
16 sg:pub.10.1007/s11481-013-9491-3
17 sg:pub.10.1038/82199
18 sg:pub.10.1038/sj.cdd.4401094
19 sg:pub.10.1186/1471-2105-8-214
20 sg:pub.10.1186/1471-2164-6-145
21 sg:pub.10.1186/1742-4690-6-47
22 https://app.dimensions.ai/details/publication/pub.1077527227
23 https://app.dimensions.ai/details/publication/pub.1078628365
24 https://app.dimensions.ai/details/publication/pub.1082862586
25 https://app.dimensions.ai/details/publication/pub.1082940601
26 https://app.dimensions.ai/details/publication/pub.1083104309
27 https://doi.org/10.1001/archneur.61.11.1687
28 https://doi.org/10.1002/elps.200410336
29 https://doi.org/10.1002/gps.3988
30 https://doi.org/10.1002/jnr.20182
31 https://doi.org/10.1002/pmic.200600026
32 https://doi.org/10.1002/pmic.200900433
33 https://doi.org/10.1002/pmic.201000722
34 https://doi.org/10.1016/b978-0-12-394592-1.00010-7
35 https://doi.org/10.1016/j.mri.2010.06.007
36 https://doi.org/10.1016/j.mvr.2006.02.002
37 https://doi.org/10.1016/j.nbd.2006.02.005
38 https://doi.org/10.1016/j.virol.2012.03.026
39 https://doi.org/10.1016/s0021-9673(00)94785-x
40 https://doi.org/10.1021/ac025747h
41 https://doi.org/10.1021/ac0341261
42 https://doi.org/10.1021/ac100890k
43 https://doi.org/10.1021/jm300180r
44 https://doi.org/10.1021/pr050405o
45 https://doi.org/10.1021/pr050455t
46 https://doi.org/10.1021/pr060132c
47 https://doi.org/10.1021/pr060474i
48 https://doi.org/10.1021/pr1009178
49 https://doi.org/10.1021/pr2001308
50 https://doi.org/10.1021/pr300414z
51 https://doi.org/10.1021/pr300624g
52 https://doi.org/10.1021/pr300918r
53 https://doi.org/10.1021/pr900634c
54 https://doi.org/10.1021/pr900685u
55 https://doi.org/10.1042/0264-6021:3560121
56 https://doi.org/10.1073/pnas.1220484110
57 https://doi.org/10.1074/mcp.m800029-mcp200
58 https://doi.org/10.1074/mcp.m900628-mcp200
59 https://doi.org/10.1080/09537100701832157
60 https://doi.org/10.1089/omi.2011.0004
61 https://doi.org/10.1091/mbc.12.10.2934
62 https://doi.org/10.1093/jxb/erj168
63 https://doi.org/10.1097/qad.0b013e328337b0ab
64 https://doi.org/10.1097/qad.0b013e3283437f9a
65 https://doi.org/10.1111/appy.12078
66 https://doi.org/10.1111/j.1471-4159.2007.04609.x
67 https://doi.org/10.1161/hypertensionaha.108.127258
68 https://doi.org/10.1212/01.wnl.0000287431.88658.8b
69 https://doi.org/10.1371/journal.ppat.1002762
70 https://doi.org/10.1515/hsz-2012-0168
71 https://doi.org/10.3109/10715762.2013.804622
72 schema:datePublished 2014-10
73 schema:datePublishedReg 2014-10-01
74 schema:description We identified and measured proteins in the cerebral spinal fluid (CSF) involved in HIV-associated neurological disorders. Protein levels were determined by mass spectrometry (MS) in pooled CSF taken from three patient groups (human immunodeficiency virus (HIV)-1-infected patients that developed HIV-associated neurocognitive disorders (HANDs), HIV-1-infected patients without HAND, and healthy controls). Pools were generated from 10 patients each per group. CSF from individual patient groups were digested with trypsin and separately labeled using with isobaric tags for relative and absolute quantitation (iTRAQ). After combining all samples in one, peptides were extensively fractionated by offline two-dimensional separation and identified by tandem MS. One hundred and ninety three proteins were deemed to be interpretable for quantitation based on permutation tests with a 95 % confidence interval with a p value ≤ 0.05. Using a cutoff of 1.5-fold for upregulation and 0.6 for downregulation, 16 proteins were differentially expressed in HIV + HAND (reporter p value ≤0.05) with seven of them previously described as HIV-interacting proteins: endoplasmin, mitochondrial damage mediator-BH3-interacting domanin death agonist, orosomucoid, apolipoprotein E, metalloproteinase inhibitor 2, peroxiredoxin-2, and the nuclear protein, ruvB-like 2. Several previously unidentified proteins with possible neurological implication in HIV patients include forming-binding protein 1, C-reactive protein, leukocyte-associated immunoglobulin receptor 1, renin receptor, mediator of RNA polymerase II transcription subunit 14, multimerin-2, alpha-N-acetylglucosaminidase, caldesmon, and cadherin EGF LAG G-type receptor. Our results suggest that not only a few but possibly a combination of biomarkers that are highly correlated can predict neurocognitive status in HIV-infected patients and might be involved in monocyte or macrophage activation.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N5f75bbc8e35b4bd198527cbee99eebc6
79 N73b807671dd84463a73c017e5a02f010
80 sg:journal.1114176
81 schema:name Identification of putative biomarkers for HIV-associated neurocognitive impairment in the CSF of HIV-infected patients under cART therapy determined by mass spectrometry
82 schema:pagination 457-465
83 schema:productId N569f3ee18ea04d2387eeb98327e59436
84 N74d0796d0435418a8fc4a8979d936359
85 N93fd3a16d17341e7bcd4a8a4be571f5c
86 Nc1cba505170a415f905792824250a6db
87 Nd350b0f5fbdf4c5c97c82398f4e58c1d
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026890024
89 https://doi.org/10.1007/s13365-014-0263-5
90 schema:sdDatePublished 2019-04-11T01:09
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Na056c39a02794633b8a14d5b005b3e41
93 schema:url http://link.springer.com/10.1007%2Fs13365-014-0263-5
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N1fb845d3be93471d952c72186db82cec rdf:first sg:person.013000215777.44
98 rdf:rest N4794893419b34f6b8a66a1c1e460b091
99 N2b93cfe6c2fb44ba8af06c2906b52676 rdf:first sg:person.013471461443.39
100 rdf:rest Nd0005d71c89946e2ab9e17e3db27bae5
101 N33fbd8e08c8847f79857b736be886f3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Adult
103 rdf:type schema:DefinedTerm
104 N3e3b92a7852d4136a5415c8fc7f270b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Anti-Retroviral Agents
106 rdf:type schema:DefinedTerm
107 N45616c05d8de4dd5b315ef155d320410 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Humans
109 rdf:type schema:DefinedTerm
110 N46d968027566497cb2459e14986ce311 rdf:first sg:person.011644322237.52
111 rdf:rest Ndf442e4278704f93aad842a761517229
112 N4794893419b34f6b8a66a1c1e460b091 rdf:first sg:person.01022060752.51
113 rdf:rest N46d968027566497cb2459e14986ce311
114 N569f3ee18ea04d2387eeb98327e59436 schema:name dimensions_id
115 schema:value pub.1026890024
116 rdf:type schema:PropertyValue
117 N57f158ad0750432bb5667265b65ba74a rdf:first sg:person.016455532612.16
118 rdf:rest Nb698091bfaaf4e3e9e301f400382cae3
119 N5f75bbc8e35b4bd198527cbee99eebc6 schema:volumeNumber 20
120 rdf:type schema:PublicationVolume
121 N6850990bee454fafa15f144cda8276ae schema:name Department of Molecular and Comparative Pathobiology-Retrovirus Laboratory, Baltimore, USA
122 rdf:type schema:Organization
123 N6a13a4a628fc4045aafe871e886fb6fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Biomarkers
125 rdf:type schema:DefinedTerm
126 N727497a2a0fe4666a13defdcf5c30e74 rdf:first sg:person.01327222362.29
127 rdf:rest N1fb845d3be93471d952c72186db82cec
128 N73b807671dd84463a73c017e5a02f010 schema:issueNumber 5
129 rdf:type schema:PublicationIssue
130 N74d0796d0435418a8fc4a8979d936359 schema:name nlm_unique_id
131 schema:value 9508123
132 rdf:type schema:PropertyValue
133 N8374185994724b0383ff06aab79e878c rdf:first sg:person.01266611216.99
134 rdf:rest N2b93cfe6c2fb44ba8af06c2906b52676
135 N93fd3a16d17341e7bcd4a8a4be571f5c schema:name pubmed_id
136 schema:value 25056907
137 rdf:type schema:PropertyValue
138 Na056c39a02794633b8a14d5b005b3e41 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 Nb698091bfaaf4e3e9e301f400382cae3 rdf:first sg:person.0715170253.46
141 rdf:rest Nbb4d6122371a44d5a447181c91e3eb90
142 Nbb14aa1d56d04c9ebba27f73ff524915 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Middle Aged
144 rdf:type schema:DefinedTerm
145 Nbb4d6122371a44d5a447181c91e3eb90 rdf:first sg:person.01064501570.98
146 rdf:rest N727497a2a0fe4666a13defdcf5c30e74
147 Nc1cba505170a415f905792824250a6db schema:name readcube_id
148 schema:value 80195ef10f5cf2e21e2d229306515eaebd53125f90cf24100377d1fca82e42f4
149 rdf:type schema:PropertyValue
150 Nc8297b59ddf44558a962d927cf75f5b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Female
152 rdf:type schema:DefinedTerm
153 Nca33109d951b4a5dab3737cd9f93af7e schema:name Department of Molecular and Comparative Pathobiology-Retrovirus Laboratory, Baltimore, USA
154 rdf:type schema:Organization
155 Nd0005d71c89946e2ab9e17e3db27bae5 rdf:first sg:person.01360101162.52
156 rdf:rest N57f158ad0750432bb5667265b65ba74a
157 Nd350b0f5fbdf4c5c97c82398f4e58c1d schema:name doi
158 schema:value 10.1007/s13365-014-0263-5
159 rdf:type schema:PropertyValue
160 Ndb4966a40b924c67af65f77fbf8763bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Mass Spectrometry
162 rdf:type schema:DefinedTerm
163 Ndb63cf72ba5146baa815eb120ed80385 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name AIDS Dementia Complex
165 rdf:type schema:DefinedTerm
166 Ndc75ffdf0b5b46b59602d1bb49c05a87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Male
168 rdf:type schema:DefinedTerm
169 Ndf442e4278704f93aad842a761517229 rdf:first sg:person.01167642705.11
170 rdf:rest rdf:nil
171 Ne375517021a742d48d0707a59e7003cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Chromatography, Liquid
173 rdf:type schema:DefinedTerm
174 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
175 schema:name Biological Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
178 schema:name Biochemistry and Cell Biology
179 rdf:type schema:DefinedTerm
180 sg:grant.2345429 http://pending.schema.org/fundedItem sg:pub.10.1007/s13365-014-0263-5
181 rdf:type schema:MonetaryGrant
182 sg:grant.2439410 http://pending.schema.org/fundedItem sg:pub.10.1007/s13365-014-0263-5
183 rdf:type schema:MonetaryGrant
184 sg:grant.2726338 http://pending.schema.org/fundedItem sg:pub.10.1007/s13365-014-0263-5
185 rdf:type schema:MonetaryGrant
186 sg:journal.1114176 schema:issn 1355-0284
187 1538-2443
188 schema:name Journal of NeuroVirology
189 rdf:type schema:Periodical
190 sg:person.01022060752.51 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
191 schema:familyName Cotter
192 schema:givenName Robert
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022060752.51
194 rdf:type schema:Person
195 sg:person.01064501570.98 schema:affiliation https://www.grid.ac/institutes/grid.410445.0
196 schema:familyName Sacktor
197 schema:givenName Ned
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064501570.98
199 rdf:type schema:Person
200 sg:person.011644322237.52 schema:affiliation https://www.grid.ac/institutes/grid.416870.c
201 schema:familyName Nath
202 schema:givenName Avindra
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011644322237.52
204 rdf:type schema:Person
205 sg:person.01167642705.11 schema:affiliation N6850990bee454fafa15f144cda8276ae
206 schema:familyName Graham
207 schema:givenName David R.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167642705.11
209 rdf:type schema:Person
210 sg:person.01266611216.99 schema:affiliation https://www.grid.ac/institutes/grid.410445.0
211 schema:familyName Bora
212 schema:givenName Adriana
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266611216.99
214 rdf:type schema:Person
215 sg:person.013000215777.44 schema:affiliation https://www.grid.ac/institutes/grid.410445.0
216 schema:familyName McArthur
217 schema:givenName Justin C.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013000215777.44
219 rdf:type schema:Person
220 sg:person.01327222362.29 schema:affiliation https://www.grid.ac/institutes/grid.410445.0
221 schema:familyName Haughey
222 schema:givenName Norman
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327222362.29
224 rdf:type schema:Person
225 sg:person.013471461443.39 schema:affiliation Nca33109d951b4a5dab3737cd9f93af7e
226 schema:familyName Mohien
227 schema:givenName Ceereena Ubaida
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013471461443.39
229 rdf:type schema:Person
230 sg:person.01360101162.52 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
231 schema:familyName Chaerkady
232 schema:givenName Raghothama
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360101162.52
234 rdf:type schema:Person
235 sg:person.016455532612.16 schema:affiliation https://www.grid.ac/institutes/grid.410445.0
236 schema:familyName Chang
237 schema:givenName Linda
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016455532612.16
239 rdf:type schema:Person
240 sg:person.0715170253.46 schema:affiliation https://www.grid.ac/institutes/grid.410445.0
241 schema:familyName 4th Moxley
242 schema:givenName Richard
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715170253.46
244 rdf:type schema:Person
245 sg:pub.10.1007/bf00731863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037537475
246 https://doi.org/10.1007/bf00731863
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s11481-013-9444-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048753101
249 https://doi.org/10.1007/s11481-013-9444-x
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/s11481-013-9491-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037242959
252 https://doi.org/10.1007/s11481-013-9491-3
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/82199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030025933
255 https://doi.org/10.1038/82199
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/sj.cdd.4401094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044651444
258 https://doi.org/10.1038/sj.cdd.4401094
259 rdf:type schema:CreativeWork
260 sg:pub.10.1186/1471-2105-8-214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027948489
261 https://doi.org/10.1186/1471-2105-8-214
262 rdf:type schema:CreativeWork
263 sg:pub.10.1186/1471-2164-6-145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038672944
264 https://doi.org/10.1186/1471-2164-6-145
265 rdf:type schema:CreativeWork
266 sg:pub.10.1186/1742-4690-6-47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018953195
267 https://doi.org/10.1186/1742-4690-6-47
268 rdf:type schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1077527227 schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1078628365 schema:CreativeWork
271 https://app.dimensions.ai/details/publication/pub.1082862586 schema:CreativeWork
272 https://app.dimensions.ai/details/publication/pub.1082940601 schema:CreativeWork
273 https://app.dimensions.ai/details/publication/pub.1083104309 schema:CreativeWork
274 https://doi.org/10.1001/archneur.61.11.1687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038251916
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1002/elps.200410336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022459243
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1002/gps.3988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037321759
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/jnr.20182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018025544
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1002/pmic.200600026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003466251
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/pmic.200900433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011646497
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/pmic.201000722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050706300
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/b978-0-12-394592-1.00010-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053262000
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.mri.2010.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013814387
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.mvr.2006.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014948667
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.nbd.2006.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028132174
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.virol.2012.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007394444
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/s0021-9673(00)94785-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050898252
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1021/ac025747h schema:sameAs https://app.dimensions.ai/details/publication/pub.1030226321
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1021/ac0341261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015001215
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1021/ac100890k schema:sameAs https://app.dimensions.ai/details/publication/pub.1009696282
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1021/jm300180r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055952913
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1021/pr050405o schema:sameAs https://app.dimensions.ai/details/publication/pub.1056290880
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1021/pr050455t schema:sameAs https://app.dimensions.ai/details/publication/pub.1056290912
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1021/pr060132c schema:sameAs https://app.dimensions.ai/details/publication/pub.1056291064
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1021/pr060474i schema:sameAs https://app.dimensions.ai/details/publication/pub.1056291257
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1021/pr1009178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052618678
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1021/pr2001308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056292522
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1021/pr300414z schema:sameAs https://app.dimensions.ai/details/publication/pub.1050502049
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1021/pr300624g schema:sameAs https://app.dimensions.ai/details/publication/pub.1056293128
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1021/pr300918r schema:sameAs https://app.dimensions.ai/details/publication/pub.1056293244
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1021/pr900634c schema:sameAs https://app.dimensions.ai/details/publication/pub.1024191701
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1021/pr900685u schema:sameAs https://app.dimensions.ai/details/publication/pub.1056295085
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1042/0264-6021:3560121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056715465
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1073/pnas.1220484110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010731684
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1074/mcp.m800029-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038596672
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1074/mcp.m900628-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041317213
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1080/09537100701832157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013095407
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1089/omi.2011.0004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059303882
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1091/mbc.12.10.2934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036874489
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1093/jxb/erj168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023550700
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1097/qad.0b013e328337b0ab schema:sameAs https://app.dimensions.ai/details/publication/pub.1051839606
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1097/qad.0b013e3283437f9a schema:sameAs https://app.dimensions.ai/details/publication/pub.1017929126
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1111/appy.12078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033134813
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1111/j.1471-4159.2007.04609.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042193376
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1161/hypertensionaha.108.127258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035341665
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1212/01.wnl.0000287431.88658.8b schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347220
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1371/journal.ppat.1002762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001962835
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1515/hsz-2012-0168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038542808
361 rdf:type schema:CreativeWork
362 https://doi.org/10.3109/10715762.2013.804622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012977505
363 rdf:type schema:CreativeWork
364 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
365 schema:name Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, USA
366 Johns Hopkins School of Medicine, Johns Hopkins University School of Medicine Mass Spectrometry and Proteomics Core, Baltimore, USA
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.410445.0 schema:alternateName University of Hawaii at Manoa
369 schema:name Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA
370 Department of Molecular and Comparative Pathobiology-Retrovirus Laboratory, Baltimore, USA
371 Department of Neurology, University of Hawaii, Honolulu, USA
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.416870.c schema:alternateName National Institute of Neurological Disorders and Stroke
374 schema:name National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
375 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...