Increased incidence of symptomatic peripheral neuropathy among adults receiving stavudine- versus zidovudine-based antiretroviral regimens in Kenya View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06

AUTHORS

Christine J. McGrath, Julia Njoroge, Grace C. John-Stewart, Pamela K. Kohler, Sarah F. Benki-Nugent, Joan W. Thiga, Anthony Etyang, Michael H. Chung

ABSTRACT

The incidence of peripheral neuropathy (PN) among adults initiating antiretroviral therapy (ART) containing stavudine (d4T) versus zidovudine (ZDV) is not well described. We compared 1-year incidence between d4T- and ZDV-based regimens in adults initiating ART in a programmatic setting in Kenya. Of 1,848 adults on ART, 1,579 (85 %) initiated d4T-based and 269 (15 %) initiated ZDV-based regimens. One-year incidence of symptomatic PN per 100 person-years was 21.9 (n=236) among d4T users and 6.9 (n=7) among ZDV users (P=0.0002). D4T was associated with 2.7 greater risk of PN than ZDV (adjusted hazard ratio, 2.7, P=0.009). In settings with continued d4T use, such as Africa, the effects of d4T on PN compared to ZDV should be considered when choosing ART regimens. More... »

PAGES

200-204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13365-012-0098-x

DOI

http://dx.doi.org/10.1007/s13365-012-0098-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000561087

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22528481


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1199", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-HIV Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kenya", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peripheral Nervous System Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Probability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stavudine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zidovudine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Global Health, University of Washington, 325 Ninth Avenue, Box 359909, 98104-2499, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McGrath", 
        "givenName": "Christine J.", 
        "id": "sg:person.01360220466.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360220466.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Global Health, University of Washington, Seattle, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Njoroge", 
        "givenName": "Julia", 
        "id": "sg:person.0617131134.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617131134.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Global Health, University of Washington, Seattle, USA", 
            "Department of Medicine, University of Washington, Seattle, USA", 
            "Department of Pediatrics, University of Washington, Seattle, USA", 
            "Department of Epidemiology, University of Washington, Seattle, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "John-Stewart", 
        "givenName": "Grace C.", 
        "id": "sg:person.01015130571.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015130571.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Global Health, University of Washington, Seattle, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohler", 
        "givenName": "Pamela K.", 
        "id": "sg:person.01142014347.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142014347.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Medicine, University of Washington, Seattle, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benki-Nugent", 
        "givenName": "Sarah F.", 
        "id": "sg:person.013457212637.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013457212637.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Coptic Hospital, Nairobi, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thiga", 
        "givenName": "Joan W.", 
        "id": "sg:person.01334572631.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334572631.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Global Health, University of Washington, Seattle, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Etyang", 
        "givenName": "Anthony", 
        "id": "sg:person.0655515760.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655515760.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Global Health, University of Washington, Seattle, USA", 
            "Department of Medicine, University of Washington, Seattle, USA", 
            "Department of Epidemiology, University of Washington, Seattle, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Michael H.", 
        "id": "sg:person.01073701147.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073701147.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02850013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000722786", 
          "https://doi.org/10.1007/bf02850013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02850013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000722786", 
          "https://doi.org/10.1007/bf02850013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e318050d66c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004369602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e318050d66c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004369602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199814000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004489545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199814000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004489545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181f5bd03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004490366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181f5bd03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004490366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181f5bd03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004490366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/426076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006240759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-199819060-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009056430", 
          "https://doi.org/10.2165/00002018-199819060-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneurol.2010.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019172954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1529-8027.2001.006001014.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019423202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1529-8027.2001.006001014.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019423202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kwj281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022676396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e318033ffa1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023706385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e318033ffa1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023706385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e318033ffa1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023706385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181568e3f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025350201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181568e3f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025350201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa012035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033299075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000159516.39982.1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033855018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000159516.39982.1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033855018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000159516.39982.1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033855018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpainsymman.2010.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038178140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)16586-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043169529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e31815acacc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048917513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e31815acacc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048917513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2007.0219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059225554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000120622.91018.ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000120622.91018.ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000120622.91018.ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000339042.96109.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000339042.96109.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000339042.96109.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181af7a22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181af7a22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181af7a22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157016209788680552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069197708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3851/imp1790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071479337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082491691", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-06", 
    "datePublishedReg": "2012-06-01", 
    "description": "The incidence of peripheral neuropathy (PN) among adults initiating antiretroviral therapy (ART) containing stavudine (d4T) versus zidovudine (ZDV) is not well described. We compared 1-year incidence between d4T- and ZDV-based regimens in adults initiating ART in a programmatic setting in Kenya. Of 1,848 adults on ART, 1,579 (85 %) initiated d4T-based and 269 (15 %) initiated ZDV-based regimens. One-year incidence of symptomatic PN per 100 person-years was 21.9 (n=236) among d4T users and 6.9 (n=7) among ZDV users (P=0.0002). D4T was associated with 2.7 greater risk of PN than ZDV (adjusted hazard ratio, 2.7, P=0.009). In settings with continued d4T use, such as Africa, the effects of d4T on PN compared to ZDV should be considered when choosing ART regimens.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13365-012-0098-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2421144", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2686693", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2405429", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2686634", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2418064", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438686", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1114176", 
        "issn": [
          "1355-0284", 
          "1538-2443"
        ], 
        "name": "Journal of NeuroVirology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Increased incidence of symptomatic peripheral neuropathy among adults receiving stavudine- versus zidovudine-based antiretroviral regimens in Kenya", 
    "pagination": "200-204", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "02abd35c94719ac9059f4d2d66e042cdb599e12704e82444e381b6643947b7cf"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22528481"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9508123"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13365-012-0098-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000561087"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13365-012-0098-x", 
      "https://app.dimensions.ai/details/publication/pub.1000561087"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000519.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs13365-012-0098-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13365-012-0098-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13365-012-0098-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13365-012-0098-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13365-012-0098-x'


 

This table displays all metadata directly associated to this object as RDF triples.

263 TRIPLES      21 PREDICATES      66 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13365-012-0098-x schema:about N2733375834054d4f98aa162ee9c984ce
2 N2ab83da3fc584377b969faa2d2d124b6
3 N30580589fe3b4a91b5e22c173f527962
4 N3517b80bc3bc4b7ba9198a87c3f7426d
5 N4604e9351df246b5bc86517a0ed0eec9
6 N47baff47d72940e38ebcd8bbe073f24f
7 N81db5b66a66e4fcb80f947d223be4a8b
8 N942a9f9ac862477f8450f1ce3688e0b9
9 N9aeff2b0824445f295b136a99498a089
10 Naf8e9b63965a4a529d2a79bef4e14849
11 Nbb40e7aadfce454c9fd8a3a8d7b512e6
12 Nbf15faac479b49c288cc1b3f1d134735
13 Nd39d66c9e5334e618373f71a01b6baab
14 Nee57ded047cf4adf8b184f49042559a5
15 anzsrc-for:11
16 anzsrc-for:1199
17 schema:author N397f3ae32c3c493ba7ba3c2c6dbde94f
18 schema:citation sg:pub.10.1007/bf02850013
19 sg:pub.10.2165/00002018-199819060-00005
20 https://app.dimensions.ai/details/publication/pub.1082491691
21 https://doi.org/10.1001/archneurol.2010.76
22 https://doi.org/10.1016/j.jpainsymman.2010.07.006
23 https://doi.org/10.1016/s0140-6736(04)16586-0
24 https://doi.org/10.1046/j.1529-8027.2001.006001014.x
25 https://doi.org/10.1056/nejmoa012035
26 https://doi.org/10.1086/426076
27 https://doi.org/10.1089/aid.2007.0219
28 https://doi.org/10.1093/aje/kwj281
29 https://doi.org/10.1097/00002030-199814000-00004
30 https://doi.org/10.1097/01.qai.0000159516.39982.1b
31 https://doi.org/10.1097/qai.0b013e318033ffa1
32 https://doi.org/10.1097/qai.0b013e318050d66c
33 https://doi.org/10.1097/qai.0b013e3181568e3f
34 https://doi.org/10.1097/qai.0b013e31815acacc
35 https://doi.org/10.1097/qai.0b013e3181f5bd03
36 https://doi.org/10.1212/01.wnl.0000120622.91018.ea
37 https://doi.org/10.1212/01.wnl.0000339042.96109.86
38 https://doi.org/10.1212/wnl.0b013e3181af7a22
39 https://doi.org/10.2174/157016209788680552
40 https://doi.org/10.3851/imp1790
41 schema:datePublished 2012-06
42 schema:datePublishedReg 2012-06-01
43 schema:description The incidence of peripheral neuropathy (PN) among adults initiating antiretroviral therapy (ART) containing stavudine (d4T) versus zidovudine (ZDV) is not well described. We compared 1-year incidence between d4T- and ZDV-based regimens in adults initiating ART in a programmatic setting in Kenya. Of 1,848 adults on ART, 1,579 (85 %) initiated d4T-based and 269 (15 %) initiated ZDV-based regimens. One-year incidence of symptomatic PN per 100 person-years was 21.9 (n=236) among d4T users and 6.9 (n=7) among ZDV users (P=0.0002). D4T was associated with 2.7 greater risk of PN than ZDV (adjusted hazard ratio, 2.7, P=0.009). In settings with continued d4T use, such as Africa, the effects of d4T on PN compared to ZDV should be considered when choosing ART regimens.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree true
47 schema:isPartOf Nadddc36a394f4548a5e65cccac113470
48 Ned472d27a30749cb87ff25bb8ad59580
49 sg:journal.1114176
50 schema:name Increased incidence of symptomatic peripheral neuropathy among adults receiving stavudine- versus zidovudine-based antiretroviral regimens in Kenya
51 schema:pagination 200-204
52 schema:productId N1ec7c9aff54042b7b6f5504ec0e23d5d
53 N4cad560d2e2343e5ae7075a6af11af44
54 N5e7d59da698e46a2a2e32fecfe1f2668
55 N64154f91937b4f008dbf84aa4fae05b3
56 Nd65e21a9136a4d688849a27d536517ba
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000561087
58 https://doi.org/10.1007/s13365-012-0098-x
59 schema:sdDatePublished 2019-04-10T21:38
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N57a0bdb56ff54ed88589b50d81c4a2f8
62 schema:url http://link.springer.com/10.1007%2Fs13365-012-0098-x
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N03d43bd931a54ae281db5fec0d90e482 rdf:first sg:person.01073701147.91
67 rdf:rest rdf:nil
68 N1ec7c9aff54042b7b6f5504ec0e23d5d schema:name readcube_id
69 schema:value 02abd35c94719ac9059f4d2d66e042cdb599e12704e82444e381b6643947b7cf
70 rdf:type schema:PropertyValue
71 N2733375834054d4f98aa162ee9c984ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Kenya
73 rdf:type schema:DefinedTerm
74 N2ab83da3fc584377b969faa2d2d124b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Humans
76 rdf:type schema:DefinedTerm
77 N30580589fe3b4a91b5e22c173f527962 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Anti-HIV Agents
79 rdf:type schema:DefinedTerm
80 N3517b80bc3bc4b7ba9198a87c3f7426d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Retrospective Studies
82 rdf:type schema:DefinedTerm
83 N36a04519fa4b446abdfd4eb499e0408f rdf:first sg:person.01334572631.81
84 rdf:rest N4ad94bdcdc054e508721b23921f5641e
85 N397f3ae32c3c493ba7ba3c2c6dbde94f rdf:first sg:person.01360220466.26
86 rdf:rest Nb4c5e74367c242c284901c847c64f51b
87 N4604e9351df246b5bc86517a0ed0eec9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Probability
89 rdf:type schema:DefinedTerm
90 N47baff47d72940e38ebcd8bbe073f24f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Incidence
92 rdf:type schema:DefinedTerm
93 N4ad94bdcdc054e508721b23921f5641e rdf:first sg:person.0655515760.28
94 rdf:rest N03d43bd931a54ae281db5fec0d90e482
95 N4cad560d2e2343e5ae7075a6af11af44 schema:name doi
96 schema:value 10.1007/s13365-012-0098-x
97 rdf:type schema:PropertyValue
98 N4da3feef3da44b0a8fe36ce45cba3de6 schema:name Coptic Hospital, Nairobi, Kenya
99 rdf:type schema:Organization
100 N57a0bdb56ff54ed88589b50d81c4a2f8 schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N5e7d59da698e46a2a2e32fecfe1f2668 schema:name dimensions_id
103 schema:value pub.1000561087
104 rdf:type schema:PropertyValue
105 N64154f91937b4f008dbf84aa4fae05b3 schema:name nlm_unique_id
106 schema:value 9508123
107 rdf:type schema:PropertyValue
108 N81db5b66a66e4fcb80f947d223be4a8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name HIV Infections
110 rdf:type schema:DefinedTerm
111 N8919c3709fec4d029b03ad8920a26015 rdf:first sg:person.01142014347.94
112 rdf:rest Nd9d67d67bf744c97bc38f10ae651ddfc
113 N942a9f9ac862477f8450f1ce3688e0b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Zidovudine
115 rdf:type schema:DefinedTerm
116 N9aeff2b0824445f295b136a99498a089 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Stavudine
118 rdf:type schema:DefinedTerm
119 N9d2bb143b926480f887da98807eece6c rdf:first sg:person.01015130571.33
120 rdf:rest N8919c3709fec4d029b03ad8920a26015
121 Nadddc36a394f4548a5e65cccac113470 schema:volumeNumber 18
122 rdf:type schema:PublicationVolume
123 Naf8e9b63965a4a529d2a79bef4e14849 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Female
125 rdf:type schema:DefinedTerm
126 Nb4c5e74367c242c284901c847c64f51b rdf:first sg:person.0617131134.83
127 rdf:rest N9d2bb143b926480f887da98807eece6c
128 Nbb40e7aadfce454c9fd8a3a8d7b512e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Male
130 rdf:type schema:DefinedTerm
131 Nbf15faac479b49c288cc1b3f1d134735 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Adult
133 rdf:type schema:DefinedTerm
134 Nd39d66c9e5334e618373f71a01b6baab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Treatment Outcome
136 rdf:type schema:DefinedTerm
137 Nd65e21a9136a4d688849a27d536517ba schema:name pubmed_id
138 schema:value 22528481
139 rdf:type schema:PropertyValue
140 Nd9d67d67bf744c97bc38f10ae651ddfc rdf:first sg:person.013457212637.73
141 rdf:rest N36a04519fa4b446abdfd4eb499e0408f
142 Nde1d13a41ac14d8b995be747a7379af8 schema:name Department of Global Health, University of Washington, 325 Ninth Avenue, Box 359909, 98104-2499, Seattle, WA, USA
143 rdf:type schema:Organization
144 Ned472d27a30749cb87ff25bb8ad59580 schema:issueNumber 3
145 rdf:type schema:PublicationIssue
146 Nee57ded047cf4adf8b184f49042559a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Peripheral Nervous System Diseases
148 rdf:type schema:DefinedTerm
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1199 schema:inDefinedTermSet anzsrc-for:
153 schema:name Other Medical and Health Sciences
154 rdf:type schema:DefinedTerm
155 sg:grant.2405429 http://pending.schema.org/fundedItem sg:pub.10.1007/s13365-012-0098-x
156 rdf:type schema:MonetaryGrant
157 sg:grant.2418064 http://pending.schema.org/fundedItem sg:pub.10.1007/s13365-012-0098-x
158 rdf:type schema:MonetaryGrant
159 sg:grant.2421144 http://pending.schema.org/fundedItem sg:pub.10.1007/s13365-012-0098-x
160 rdf:type schema:MonetaryGrant
161 sg:grant.2438686 http://pending.schema.org/fundedItem sg:pub.10.1007/s13365-012-0098-x
162 rdf:type schema:MonetaryGrant
163 sg:grant.2686634 http://pending.schema.org/fundedItem sg:pub.10.1007/s13365-012-0098-x
164 rdf:type schema:MonetaryGrant
165 sg:grant.2686693 http://pending.schema.org/fundedItem sg:pub.10.1007/s13365-012-0098-x
166 rdf:type schema:MonetaryGrant
167 sg:journal.1114176 schema:issn 1355-0284
168 1538-2443
169 schema:name Journal of NeuroVirology
170 rdf:type schema:Periodical
171 sg:person.01015130571.33 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
172 schema:familyName John-Stewart
173 schema:givenName Grace C.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015130571.33
175 rdf:type schema:Person
176 sg:person.01073701147.91 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
177 schema:familyName Chung
178 schema:givenName Michael H.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073701147.91
180 rdf:type schema:Person
181 sg:person.01142014347.94 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
182 schema:familyName Kohler
183 schema:givenName Pamela K.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142014347.94
185 rdf:type schema:Person
186 sg:person.01334572631.81 schema:affiliation N4da3feef3da44b0a8fe36ce45cba3de6
187 schema:familyName Thiga
188 schema:givenName Joan W.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334572631.81
190 rdf:type schema:Person
191 sg:person.013457212637.73 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
192 schema:familyName Benki-Nugent
193 schema:givenName Sarah F.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013457212637.73
195 rdf:type schema:Person
196 sg:person.01360220466.26 schema:affiliation Nde1d13a41ac14d8b995be747a7379af8
197 schema:familyName McGrath
198 schema:givenName Christine J.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360220466.26
200 rdf:type schema:Person
201 sg:person.0617131134.83 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
202 schema:familyName Njoroge
203 schema:givenName Julia
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617131134.83
205 rdf:type schema:Person
206 sg:person.0655515760.28 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
207 schema:familyName Etyang
208 schema:givenName Anthony
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655515760.28
210 rdf:type schema:Person
211 sg:pub.10.1007/bf02850013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000722786
212 https://doi.org/10.1007/bf02850013
213 rdf:type schema:CreativeWork
214 sg:pub.10.2165/00002018-199819060-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009056430
215 https://doi.org/10.2165/00002018-199819060-00005
216 rdf:type schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1082491691 schema:CreativeWork
218 https://doi.org/10.1001/archneurol.2010.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019172954
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.jpainsymman.2010.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038178140
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/s0140-6736(04)16586-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043169529
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1046/j.1529-8027.2001.006001014.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019423202
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1056/nejmoa012035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033299075
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1086/426076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006240759
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1089/aid.2007.0219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059225554
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1093/aje/kwj281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022676396
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1097/00002030-199814000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004489545
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1097/01.qai.0000159516.39982.1b schema:sameAs https://app.dimensions.ai/details/publication/pub.1033855018
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1097/qai.0b013e318033ffa1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023706385
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1097/qai.0b013e318050d66c schema:sameAs https://app.dimensions.ai/details/publication/pub.1004369602
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/qai.0b013e3181568e3f schema:sameAs https://app.dimensions.ai/details/publication/pub.1025350201
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/qai.0b013e31815acacc schema:sameAs https://app.dimensions.ai/details/publication/pub.1048917513
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1097/qai.0b013e3181f5bd03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004490366
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1212/01.wnl.0000120622.91018.ea schema:sameAs https://app.dimensions.ai/details/publication/pub.1064345896
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1212/01.wnl.0000339042.96109.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064350814
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1212/wnl.0b013e3181af7a22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354500
253 rdf:type schema:CreativeWork
254 https://doi.org/10.2174/157016209788680552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069197708
255 rdf:type schema:CreativeWork
256 https://doi.org/10.3851/imp1790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071479337
257 rdf:type schema:CreativeWork
258 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
259 schema:name Department of Epidemiology, University of Washington, Seattle, USA
260 Department of Global Health, University of Washington, Seattle, USA
261 Department of Medicine, University of Washington, Seattle, USA
262 Department of Pediatrics, University of Washington, Seattle, USA
263 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...