Mass Spectrometry-Based Integration and Expansion of the Chemical Diversity Harbored Within a Marine Sponge View Full Text


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Article Info

DATE

2019-05-15

AUTHORS

Thomas P. Cantrell, Christopher J. Freeman, Valerie J. Paul, Vinayak Agarwal, Neha Garg

ABSTRACT

Marine sponges and their associated symbionts produce a structurally diverse and complex set of natural products including alkaloids, terpenoids, peptides, lipids, and steroids. A single sponge with its symbionts can produce all of the above-mentioned classes of molecules and their analogs. Most approaches to evaluating sponge chemical diversity have focused on major metabolites that can be isolated and characterized; therefore, a comprehensive evaluation of intra- (within a molecular family; analogs) and inter-chemical diversity within a single sponge remains incomplete. We use a combination of metabolomics tools, including a supervised approach via manual library search and literature search, and an unsupervised approach via molecular networking and MS2LDA analysis to describe the intra and inter-chemical diversity present in Smenospongia aurea. Furthermore, we use imaging mass spectrometry to link this chemical diversity to either the sponge or the associated cyanobacteria. Using these approaches, we identify seven more molecular features that represent analogs of four previously known peptide/polyketide smenamides and assign the biosynthesis of these molecules to the symbiotic cyanobacteria by imaging mass spectrometry. We extend this analysis to a wide diversity of molecular classes including indole alkaloids and meroterpenes. More... »

PAGES

1373-1384

References to SciGraph publications

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  • 2016-08-09. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking in NATURE BIOTECHNOLOGY
  • 1994-04. A brominated secondary metabolite synthesized by the cyanobacterial symbiont of a marine sponge and accumulation of the crystalline metabolite in the sponge tissue in MARINE BIOLOGY
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  • 2007-08. The Metabolomics Standards Initiative in NATURE BIOTECHNOLOGY
  • 2013-03-01. Computational mass spectrometry for small molecules in JOURNAL OF CHEMINFORMATICS
  • 2015-08-03. Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms in NATURE CHEMICAL BIOLOGY
  • 2007-09-12. Proposed minimum reporting standards for chemical analysis in METABOLOMICS
  • 2005-04-22. Identification of the cellular site of polychlorinated peptide biosynthesis in the marine sponge Dysidea (Lamellodysidea) herbacea and symbiotic cyanobacterium Oscillatoria spongeliae by CARD-FISH analysis in MARINE BIOLOGY
  • 2011-01-28. Metabolomics: from small molecules to big ideas in NATURE METHODS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13361-019-02207-5

    DOI

    http://dx.doi.org/10.1007/s13361-019-02207-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1114346980

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31093948


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