Family of melanocortin receptor (MCR) genes in mammals—mutations, polymorphisms and phenotypic effects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11

AUTHORS

M. Switonski, M. Mankowska, S. Salamon

ABSTRACT

The melanocortin receptor gene family consists of five single-exon members, which are located on autosomes. Three genes (MC2R, MC4R and MC5R) are syntenic in the human, mouse, cattle and dog genomes, while in the pig, the syntenic group comprises MC1R, MC2R and MC5R. Two genes (MC1R and MC4R) have been extensively studied due to their function in melanogenesis (MC1R) and energy control (MC4R). Conservative organisation of these genes in five mammalian species (human, mouse, cattle, pig and dog), in terms of the encoded amino acid sequence, is higher in the case of MC4R compared to MC1R. Polymorphisms of these two genes are responsible or associated with variation of pigmentation (MC1R) and adipose tissue deposition (MC4R). Polymorphic variants in MC1R, causing coat colour variation, were described in humans and domestic mammals (cattle, horse, pig, sheep, dog), as well as farm red and arctic foxes. The MC4R gene is very polymorphic in humans and it is well known that some variants cause monogenic obesity or significantly contribute to the development of polygenic obesity. Such relationships are not so evident in domestic mammals; however, at least one missense substitution (298Asp > Asn) in the porcine MC4R significantly contributes, at least in some breeds, to fat tissue accumulation, feed conversion ratio and daily weight gain. Knowledge on the phenotypic effects of polymorphisms of MC2R, MC3R and MC5R in domestic mammals is scarce, probably due to the small number of reports addressing these genes. Thus, further studies focused on these genes should be undertaken. More... »

PAGES

461-472

References to SciGraph publications

  • 1996-04. Red coat color in Holstein cattle is associated with a deletion in the MSHR gene in MAMMALIAN GENOME
  • 2012-05. Distribution and linkage disequilibrium analysis of polymorphisms of MC4R, LEP, H-FABP genes in the different populations of pigs, associated with economic traits in DIV2 line in MOLECULAR BIOLOGY REPORTS
  • 1997-03. A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes in NATURE GENETICS
  • 1996-12. A missense mutation in the gene for melanocyte-stimulating hormone receptor (MCIR) is associated with the chestnut coat color in horses in MAMMALIAN GENOME
  • 2008-04. ACTH Receptor Promoter Polymorphism Associates With Severity of Premature Adrenarche and Modulates Hypothalamo-Pituitary-Adrenal Axis in Children in PEDIATRIC RESEARCH
  • 2009-09. Association between variants in the 5′-untranslated region of the bovine MC4R gene and two growth traits in Nanyang cattle in MOLECULAR BIOLOGY REPORTS
  • 1997-10. Linkage and Association Studies between the Melanocortin Receptors 4 and 5 Genes and Obesity-Related Phenotypes in the Québec Family Study in MOLECULAR MEDICINE
  • 2000-02. A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits in MAMMALIAN GENOME
  • 2001-04. Expression, Candidate Gene, and Population Studies of the Melanocortin 5 Receptor in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2010. Melanocortin Signalling Mechanisms in MELANOCORTINS: MULTIPLE ACTIONS AND THERAPEUTIC POTENTIAL
  • 1995-09. The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination in MAMMALIAN GENOME
  • 2012-04. Identification and analysis of MC4R polymorphisms and their association with economic traits of Korean cattle (Hanwoo) in MOLECULAR BIOLOGY REPORTS
  • 2008-06. Common variants near MC4R are associated with fat mass, weight and risk of obesity in NATURE GENETICS
  • 2000-01. Melanocortin 1 receptor variation in the domestic dog in MAMMALIAN GENOME
  • 1999-01. Molecular and pharmacological characterization of dominant black coat color in sheep in MAMMALIAN GENOME
  • 2010-12. Polymorphisms in MC4R gene and correlations with economic traits in cattle in MOLECULAR BIOLOGY REPORTS
  • 2010-01. Mutations of MC4R gene and its association with economic traits in Qinchuan cattle in MOLECULAR BIOLOGY REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13353-013-0163-z

    DOI

    http://dx.doi.org/10.1007/s13353-013-0163-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008985852

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23996627


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cattle", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dogs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Horses", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mammals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multigene Family", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Melanocortin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sheep", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Swine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Synteny", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Life Sciences in Pozna\u0144", 
              "id": "https://www.grid.ac/institutes/grid.410688.3", 
              "name": [
                "Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Switonski", 
            "givenName": "M.", 
            "id": "sg:person.0666405002.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666405002.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Life Sciences in Pozna\u0144", 
              "id": "https://www.grid.ac/institutes/grid.410688.3", 
              "name": [
                "Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mankowska", 
            "givenName": "M.", 
            "id": "sg:person.0723202131.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723202131.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Life Sciences in Pozna\u0144", 
              "id": "https://www.grid.ac/institutes/grid.410688.3", 
              "name": [
                "Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salamon", 
            "givenName": "S.", 
            "id": "sg:person.01200514566.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200514566.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s11033-012-1454-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000284445", 
              "https://doi.org/10.1007/s11033-012-1454-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2006.01414.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000339778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/jme-09-0161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001492591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.schres.2009.05.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001928756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2052.2001.00750.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002952313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2052.2002.00899.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002968551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.meatsci.2006.03.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003314692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-010-0051-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003547287", 
              "https://doi.org/10.1007/s11033-010-0051-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-010-0051-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003547287", 
              "https://doi.org/10.1007/s11033-010-0051-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jhered/esq061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003550901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2010.02075.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004304381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.meatsci.2009.10.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004617535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.meatsci.2011.11.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004675134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2006.01488.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004980958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2010.02049.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005052283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2010.02049.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005052283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4141/cjas10074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006600978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2004.01148.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007403064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1043-2760(93)90129-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007506285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.meatsci.2005.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009393213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2011.02279.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011200308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2009.01853.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011637258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2009.01853.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011637258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-009-9706-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011650710", 
              "https://doi.org/10.1007/s11033-009-9706-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-009-9706-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011650710", 
              "https://doi.org/10.1007/s11033-009-9706-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-009-9706-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011650710", 
              "https://doi.org/10.1007/s11033-009-9706-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejphar.2010.12.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011693654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2008.313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014527535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/pdr.0b013e3181659c14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016622611", 
              "https://doi.org/10.1203/pdr.0b013e3181659c14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/pdr.0b013e3181659c14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016622611", 
              "https://doi.org/10.1203/pdr.0b013e3181659c14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2052.2000.00639.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017275638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2052.2000.00639.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017275638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0303-7207(02)00410-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018436493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0303-7207(02)00410-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018436493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0045731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020290807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.bjp.0706929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020405475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4419-6354-3_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020561082", 
              "https://doi.org/10.1007/978-1-4419-6354-3_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4419-6354-3_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020561082", 
              "https://doi.org/10.1007/978-1-4419-6354-3_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-008-9388-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020705999", 
              "https://doi.org/10.1007/s11033-008-9388-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-008-9388-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020705999", 
              "https://doi.org/10.1007/s11033-008-9388-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/geno.1996.0460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021062748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m603454200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021413330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jbg.12005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021588885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0706953104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022381201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-011-1133-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022689082", 
              "https://doi.org/10.1007/s11033-011-1133-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jhered/esg014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023274430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2423(09)48004-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024669948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.278374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024705623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.278374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024705623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2052.2001.0781b.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025123611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.domaniend.2011.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025205259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/jme.0.0320145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026332911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gene.2006.12.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026376365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2004.01182.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026760562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026795787", 
              "https://doi.org/10.1038/ng.140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2004.01191.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027778563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.meatsci.2005.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028458084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0397-311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029845575", 
              "https://doi.org/10.1038/ng0397-311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.0022-202x.2001.01286.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030333812", 
              "https://doi.org/10.1046/j.0022-202x.2001.01286.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.peptides.2004.11.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030476922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.meatsci.2010.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031999119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1439-0388.2006.00559.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032675890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1439-0388.2006.00559.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032675890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.meatsci.2010.12.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033869732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1751-1097.2011.00970.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034224964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s003359900264", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034289901", 
              "https://doi.org/10.1007/s003359900264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diabetes.54.suppl_2.s114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034782212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1877-1173(09)88006-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036204378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2006.01482.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037137030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00352371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038610817", 
              "https://doi.org/10.1007/bf00352371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s003350010005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038875688", 
              "https://doi.org/10.1007/s003350010005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejphar.2011.01.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041068830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s003350010025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044191760", 
              "https://doi.org/10.1007/s003350010025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2052.2005.01373.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045713029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.domaniend.2003.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045922733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.domaniend.2007.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046223234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcp.2012.03.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047563403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neulet.2008.02.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047777303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/joe-12-0501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049126091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1439-0388.2008.00770.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050345540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1439-0388.2008.00770.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050345540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s003359900090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051514971", 
              "https://doi.org/10.1007/s003359900090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s003359900939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053071779", 
              "https://doi.org/10.1007/s003359900939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1751731107000456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054944134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1751731107000456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054944134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi3013593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055205548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e328333a172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e328333a172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e328333a172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e328333a172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1325670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062475371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2008-0941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064249596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.2006-0034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064285872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.2009-0037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064285980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/me.2009-0283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064328383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074667771", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074834165", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077812078", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00029330-200809010-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077812078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078227097", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03401705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083182095", 
              "https://doi.org/10.1007/bf03401705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083340412", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.17221/169/2010-cjas", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100963234"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-11", 
        "datePublishedReg": "2013-11-01", 
        "description": "The melanocortin receptor gene family consists of five single-exon members, which are located on autosomes. Three genes (MC2R, MC4R and MC5R) are syntenic in the human, mouse, cattle and dog genomes, while in the pig, the syntenic group comprises MC1R, MC2R and MC5R. Two genes (MC1R and MC4R) have been extensively studied due to their function in melanogenesis (MC1R) and energy control (MC4R). Conservative organisation of these genes in five mammalian species (human, mouse, cattle, pig and dog), in terms of the encoded amino acid sequence, is higher in the case of MC4R compared to MC1R. Polymorphisms of these two genes are responsible or associated with variation of pigmentation (MC1R) and adipose tissue deposition (MC4R). Polymorphic variants in MC1R, causing coat colour variation, were described in humans and domestic mammals (cattle, horse, pig, sheep, dog), as well as farm red and arctic foxes. The MC4R gene is very polymorphic in humans and it is well known that some variants cause monogenic obesity or significantly contribute to the development of polygenic obesity. Such relationships are not so evident in domestic mammals; however, at least one missense substitution (298Asp\u2009>\u2009Asn) in the porcine MC4R significantly contributes, at least in some breeds, to fat tissue accumulation, feed conversion ratio and daily weight gain. Knowledge on the phenotypic effects of polymorphisms of MC2R, MC3R and MC5R in domestic mammals is scarce, probably due to the small number of reports addressing these genes. Thus, further studies focused on these genes should be undertaken. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s13353-013-0163-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1114642", 
            "issn": [
              "1234-1983", 
              "2190-3883"
            ], 
            "name": "Journal of Applied Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "54"
          }
        ], 
        "name": "Family of melanocortin receptor (MCR) genes in mammals\u2014mutations, polymorphisms and phenotypic effects", 
        "pagination": "461-472", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2acf02780ab5006b49bde33055a67adb6103fed7c946a0818c5052809ebbef0f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23996627"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9514582"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s13353-013-0163-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1008985852"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s13353-013-0163-z", 
          "https://app.dimensions.ai/details/publication/pub.1008985852"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000581.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs13353-013-0163-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13353-013-0163-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13353-013-0163-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13353-013-0163-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13353-013-0163-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    413 TRIPLES      21 PREDICATES      130 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s13353-013-0163-z schema:about N0e8d49f32ba34fceb200ea884bc8a27b
    2 N1aa5a8b4179f42c9970dd4d4a25d2c26
    3 N1c9ca3751b2b40378d25989836ee2d8c
    4 N2fb4497d53484d5fbd8fb41dc6a55749
    5 N316143c8b71a417ea5ed3bd96d39f1de
    6 N3216b953ade44adea39847c9d723cb0a
    7 N4c1475f4de834ab6b5888df697c73d50
    8 N59afd3c0ab144db58ca82c69e3479e44
    9 N6b53123d2e694c459cf1ad990d33bda7
    10 Nd64de4fad5e14a7494fe8488e55059af
    11 Ne6090413fc53490dabe108a640196004
    12 Neb1bfe34adc24af7b879f1985697d11e
    13 Nf14197623931453280b0b803d0938652
    14 Nf216c18a3fc84234b06b6cdce63e93f8
    15 Nf7274fc609694c8988f94f8c7493bef0
    16 anzsrc-for:06
    17 anzsrc-for:0604
    18 schema:author Ne7984ddcc80a4c00beea6985e1f06f57
    19 schema:citation sg:pub.10.1007/978-1-4419-6354-3_2
    20 sg:pub.10.1007/bf00352371
    21 sg:pub.10.1007/bf03401705
    22 sg:pub.10.1007/s003350010005
    23 sg:pub.10.1007/s003350010025
    24 sg:pub.10.1007/s003359900090
    25 sg:pub.10.1007/s003359900264
    26 sg:pub.10.1007/s003359900939
    27 sg:pub.10.1007/s11033-008-9388-z
    28 sg:pub.10.1007/s11033-009-9706-0
    29 sg:pub.10.1007/s11033-010-0051-0
    30 sg:pub.10.1007/s11033-011-1133-3
    31 sg:pub.10.1007/s11033-012-1454-x
    32 sg:pub.10.1038/ng.140
    33 sg:pub.10.1038/ng0397-311
    34 sg:pub.10.1046/j.0022-202x.2001.01286.x
    35 sg:pub.10.1203/pdr.0b013e3181659c14
    36 https://app.dimensions.ai/details/publication/pub.1074667771
    37 https://app.dimensions.ai/details/publication/pub.1074834165
    38 https://app.dimensions.ai/details/publication/pub.1077812078
    39 https://app.dimensions.ai/details/publication/pub.1078227097
    40 https://app.dimensions.ai/details/publication/pub.1083340412
    41 https://doi.org/10.1006/geno.1996.0460
    42 https://doi.org/10.1016/1043-2760(93)90129-3
    43 https://doi.org/10.1016/j.domaniend.2003.12.001
    44 https://doi.org/10.1016/j.domaniend.2007.05.003
    45 https://doi.org/10.1016/j.domaniend.2011.05.002
    46 https://doi.org/10.1016/j.ejphar.2010.12.020
    47 https://doi.org/10.1016/j.ejphar.2011.01.033
    48 https://doi.org/10.1016/j.gene.2006.12.027
    49 https://doi.org/10.1016/j.mcp.2012.03.009
    50 https://doi.org/10.1016/j.meatsci.2005.10.016
    51 https://doi.org/10.1016/j.meatsci.2005.11.007
    52 https://doi.org/10.1016/j.meatsci.2006.03.022
    53 https://doi.org/10.1016/j.meatsci.2009.10.025
    54 https://doi.org/10.1016/j.meatsci.2010.01.017
    55 https://doi.org/10.1016/j.meatsci.2010.12.018
    56 https://doi.org/10.1016/j.meatsci.2011.11.025
    57 https://doi.org/10.1016/j.neulet.2008.02.042
    58 https://doi.org/10.1016/j.peptides.2004.11.040
    59 https://doi.org/10.1016/j.schres.2009.05.014
    60 https://doi.org/10.1016/s0065-2423(09)48004-1
    61 https://doi.org/10.1016/s0303-7207(02)00410-0
    62 https://doi.org/10.1016/s1877-1173(09)88006-x
    63 https://doi.org/10.1017/s1751731107000456
    64 https://doi.org/10.1021/bi3013593
    65 https://doi.org/10.1038/oby.2008.313
    66 https://doi.org/10.1038/sj.bjp.0706929
    67 https://doi.org/10.1046/j.1365-2052.2000.00639.x
    68 https://doi.org/10.1046/j.1365-2052.2001.00750.x
    69 https://doi.org/10.1046/j.1365-2052.2001.0781b.x
    70 https://doi.org/10.1046/j.1365-2052.2002.00899.x
    71 https://doi.org/10.1073/pnas.0706953104
    72 https://doi.org/10.1074/jbc.m111.278374
    73 https://doi.org/10.1074/jbc.m603454200
    74 https://doi.org/10.1093/jhered/esg014
    75 https://doi.org/10.1093/jhered/esq061
    76 https://doi.org/10.1097/00029330-200809010-00006
    77 https://doi.org/10.1097/fpc.0b013e328333a172
    78 https://doi.org/10.1111/j.1365-2052.2004.01148.x
    79 https://doi.org/10.1111/j.1365-2052.2004.01182.x
    80 https://doi.org/10.1111/j.1365-2052.2004.01191.x
    81 https://doi.org/10.1111/j.1365-2052.2005.01373.x
    82 https://doi.org/10.1111/j.1365-2052.2006.01414.x
    83 https://doi.org/10.1111/j.1365-2052.2006.01482.x
    84 https://doi.org/10.1111/j.1365-2052.2006.01488.x
    85 https://doi.org/10.1111/j.1365-2052.2009.01853.x
    86 https://doi.org/10.1111/j.1365-2052.2010.02049.x
    87 https://doi.org/10.1111/j.1365-2052.2010.02075.x
    88 https://doi.org/10.1111/j.1365-2052.2011.02279.x
    89 https://doi.org/10.1111/j.1439-0388.2006.00559.x
    90 https://doi.org/10.1111/j.1439-0388.2008.00770.x
    91 https://doi.org/10.1111/j.1751-1097.2011.00970.x
    92 https://doi.org/10.1111/jbg.12005
    93 https://doi.org/10.1126/science.1325670
    94 https://doi.org/10.1210/en.2008-0941
    95 https://doi.org/10.1210/er.2006-0034
    96 https://doi.org/10.1210/er.2009-0037
    97 https://doi.org/10.1210/me.2009-0283
    98 https://doi.org/10.1371/journal.pone.0045731
    99 https://doi.org/10.1530/joe-12-0501
    100 https://doi.org/10.1677/jme-09-0161
    101 https://doi.org/10.1677/jme.0.0320145
    102 https://doi.org/10.17221/169/2010-cjas
    103 https://doi.org/10.2337/diabetes.54.suppl_2.s114
    104 https://doi.org/10.4141/cjas10074
    105 schema:datePublished 2013-11
    106 schema:datePublishedReg 2013-11-01
    107 schema:description The melanocortin receptor gene family consists of five single-exon members, which are located on autosomes. Three genes (MC2R, MC4R and MC5R) are syntenic in the human, mouse, cattle and dog genomes, while in the pig, the syntenic group comprises MC1R, MC2R and MC5R. Two genes (MC1R and MC4R) have been extensively studied due to their function in melanogenesis (MC1R) and energy control (MC4R). Conservative organisation of these genes in five mammalian species (human, mouse, cattle, pig and dog), in terms of the encoded amino acid sequence, is higher in the case of MC4R compared to MC1R. Polymorphisms of these two genes are responsible or associated with variation of pigmentation (MC1R) and adipose tissue deposition (MC4R). Polymorphic variants in MC1R, causing coat colour variation, were described in humans and domestic mammals (cattle, horse, pig, sheep, dog), as well as farm red and arctic foxes. The MC4R gene is very polymorphic in humans and it is well known that some variants cause monogenic obesity or significantly contribute to the development of polygenic obesity. Such relationships are not so evident in domestic mammals; however, at least one missense substitution (298Asp > Asn) in the porcine MC4R significantly contributes, at least in some breeds, to fat tissue accumulation, feed conversion ratio and daily weight gain. Knowledge on the phenotypic effects of polymorphisms of MC2R, MC3R and MC5R in domestic mammals is scarce, probably due to the small number of reports addressing these genes. Thus, further studies focused on these genes should be undertaken.
    108 schema:genre research_article
    109 schema:inLanguage en
    110 schema:isAccessibleForFree true
    111 schema:isPartOf N8eb056e1214a4c18a5a6850d14250510
    112 Nc4198b9a663c49aca4cd00d75f5d8625
    113 sg:journal.1114642
    114 schema:name Family of melanocortin receptor (MCR) genes in mammals—mutations, polymorphisms and phenotypic effects
    115 schema:pagination 461-472
    116 schema:productId N7b5fdac4c7024a87bc6b85e214ff4484
    117 N97afd8e2ddd6447c87a623822036e964
    118 Nc8d6ea9a823543a5a152cf7c281b1bc7
    119 Nd52d3a66c1e94623996f8a9506e39a92
    120 Nd8df98f889f94897bfb9d618c16b873c
    121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008985852
    122 https://doi.org/10.1007/s13353-013-0163-z
    123 schema:sdDatePublished 2019-04-10T13:29
    124 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    125 schema:sdPublisher N9e8adce59d6f4508a8a57aff757c16b4
    126 schema:url http://link.springer.com/10.1007%2Fs13353-013-0163-z
    127 sgo:license sg:explorer/license/
    128 sgo:sdDataset articles
    129 rdf:type schema:ScholarlyArticle
    130 N0e8d49f32ba34fceb200ea884bc8a27b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Mammals
    132 rdf:type schema:DefinedTerm
    133 N17cb139fd02647f9b23cc188d75d114b rdf:first sg:person.0723202131.74
    134 rdf:rest N80c3a93421d64287aeeff1a46382182a
    135 N1aa5a8b4179f42c9970dd4d4a25d2c26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Dogs
    137 rdf:type schema:DefinedTerm
    138 N1c9ca3751b2b40378d25989836ee2d8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Phenotype
    140 rdf:type schema:DefinedTerm
    141 N2fb4497d53484d5fbd8fb41dc6a55749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Receptors, Melanocortin
    143 rdf:type schema:DefinedTerm
    144 N316143c8b71a417ea5ed3bd96d39f1de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Cattle
    146 rdf:type schema:DefinedTerm
    147 N3216b953ade44adea39847c9d723cb0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Polymorphism, Genetic
    149 rdf:type schema:DefinedTerm
    150 N4c1475f4de834ab6b5888df697c73d50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Mutation
    152 rdf:type schema:DefinedTerm
    153 N59afd3c0ab144db58ca82c69e3479e44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Mice
    155 rdf:type schema:DefinedTerm
    156 N6b53123d2e694c459cf1ad990d33bda7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Swine
    158 rdf:type schema:DefinedTerm
    159 N7b5fdac4c7024a87bc6b85e214ff4484 schema:name nlm_unique_id
    160 schema:value 9514582
    161 rdf:type schema:PropertyValue
    162 N80c3a93421d64287aeeff1a46382182a rdf:first sg:person.01200514566.32
    163 rdf:rest rdf:nil
    164 N8eb056e1214a4c18a5a6850d14250510 schema:volumeNumber 54
    165 rdf:type schema:PublicationVolume
    166 N97afd8e2ddd6447c87a623822036e964 schema:name dimensions_id
    167 schema:value pub.1008985852
    168 rdf:type schema:PropertyValue
    169 N9e8adce59d6f4508a8a57aff757c16b4 schema:name Springer Nature - SN SciGraph project
    170 rdf:type schema:Organization
    171 Nc4198b9a663c49aca4cd00d75f5d8625 schema:issueNumber 4
    172 rdf:type schema:PublicationIssue
    173 Nc8d6ea9a823543a5a152cf7c281b1bc7 schema:name doi
    174 schema:value 10.1007/s13353-013-0163-z
    175 rdf:type schema:PropertyValue
    176 Nd52d3a66c1e94623996f8a9506e39a92 schema:name pubmed_id
    177 schema:value 23996627
    178 rdf:type schema:PropertyValue
    179 Nd64de4fad5e14a7494fe8488e55059af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Horses
    181 rdf:type schema:DefinedTerm
    182 Nd8df98f889f94897bfb9d618c16b873c schema:name readcube_id
    183 schema:value 2acf02780ab5006b49bde33055a67adb6103fed7c946a0818c5052809ebbef0f
    184 rdf:type schema:PropertyValue
    185 Ne6090413fc53490dabe108a640196004 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Multigene Family
    187 rdf:type schema:DefinedTerm
    188 Ne7984ddcc80a4c00beea6985e1f06f57 rdf:first sg:person.0666405002.48
    189 rdf:rest N17cb139fd02647f9b23cc188d75d114b
    190 Neb1bfe34adc24af7b879f1985697d11e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Synteny
    192 rdf:type schema:DefinedTerm
    193 Nf14197623931453280b0b803d0938652 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Humans
    195 rdf:type schema:DefinedTerm
    196 Nf216c18a3fc84234b06b6cdce63e93f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Animals
    198 rdf:type schema:DefinedTerm
    199 Nf7274fc609694c8988f94f8c7493bef0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Sheep
    201 rdf:type schema:DefinedTerm
    202 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Biological Sciences
    204 rdf:type schema:DefinedTerm
    205 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    206 schema:name Genetics
    207 rdf:type schema:DefinedTerm
    208 sg:journal.1114642 schema:issn 1234-1983
    209 2190-3883
    210 schema:name Journal of Applied Genetics
    211 rdf:type schema:Periodical
    212 sg:person.01200514566.32 schema:affiliation https://www.grid.ac/institutes/grid.410688.3
    213 schema:familyName Salamon
    214 schema:givenName S.
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200514566.32
    216 rdf:type schema:Person
    217 sg:person.0666405002.48 schema:affiliation https://www.grid.ac/institutes/grid.410688.3
    218 schema:familyName Switonski
    219 schema:givenName M.
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666405002.48
    221 rdf:type schema:Person
    222 sg:person.0723202131.74 schema:affiliation https://www.grid.ac/institutes/grid.410688.3
    223 schema:familyName Mankowska
    224 schema:givenName M.
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723202131.74
    226 rdf:type schema:Person
    227 sg:pub.10.1007/978-1-4419-6354-3_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020561082
    228 https://doi.org/10.1007/978-1-4419-6354-3_2
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/bf00352371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038610817
    231 https://doi.org/10.1007/bf00352371
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/bf03401705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083182095
    234 https://doi.org/10.1007/bf03401705
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s003350010005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038875688
    237 https://doi.org/10.1007/s003350010005
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s003350010025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044191760
    240 https://doi.org/10.1007/s003350010025
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1007/s003359900090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051514971
    243 https://doi.org/10.1007/s003359900090
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1007/s003359900264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034289901
    246 https://doi.org/10.1007/s003359900264
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1007/s003359900939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053071779
    249 https://doi.org/10.1007/s003359900939
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/s11033-008-9388-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1020705999
    252 https://doi.org/10.1007/s11033-008-9388-z
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1007/s11033-009-9706-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011650710
    255 https://doi.org/10.1007/s11033-009-9706-0
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1007/s11033-010-0051-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003547287
    258 https://doi.org/10.1007/s11033-010-0051-0
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/s11033-011-1133-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022689082
    261 https://doi.org/10.1007/s11033-011-1133-3
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s11033-012-1454-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000284445
    264 https://doi.org/10.1007/s11033-012-1454-x
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/ng.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026795787
    267 https://doi.org/10.1038/ng.140
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/ng0397-311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029845575
    270 https://doi.org/10.1038/ng0397-311
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1046/j.0022-202x.2001.01286.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030333812
    273 https://doi.org/10.1046/j.0022-202x.2001.01286.x
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1203/pdr.0b013e3181659c14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016622611
    276 https://doi.org/10.1203/pdr.0b013e3181659c14
    277 rdf:type schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1074667771 schema:CreativeWork
    279 https://app.dimensions.ai/details/publication/pub.1074834165 schema:CreativeWork
    280 https://app.dimensions.ai/details/publication/pub.1077812078 schema:CreativeWork
    281 https://app.dimensions.ai/details/publication/pub.1078227097 schema:CreativeWork
    282 https://app.dimensions.ai/details/publication/pub.1083340412 schema:CreativeWork
    283 https://doi.org/10.1006/geno.1996.0460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021062748
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/1043-2760(93)90129-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007506285
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.domaniend.2003.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045922733
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.domaniend.2007.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046223234
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.domaniend.2011.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025205259
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.ejphar.2010.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011693654
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.ejphar.2011.01.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041068830
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.gene.2006.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026376365
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.mcp.2012.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047563403
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.meatsci.2005.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009393213
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.meatsci.2005.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028458084
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/j.meatsci.2006.03.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003314692
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.meatsci.2009.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004617535
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.meatsci.2010.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031999119
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.meatsci.2010.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033869732
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.meatsci.2011.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004675134
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.neulet.2008.02.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047777303
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.peptides.2004.11.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030476922
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.schres.2009.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001928756
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/s0065-2423(09)48004-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024669948
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s0303-7207(02)00410-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018436493
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s1877-1173(09)88006-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036204378
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1017/s1751731107000456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054944134
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1021/bi3013593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055205548
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1038/oby.2008.313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014527535
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1038/sj.bjp.0706929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020405475
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1046/j.1365-2052.2000.00639.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017275638
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1046/j.1365-2052.2001.00750.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002952313
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1046/j.1365-2052.2001.0781b.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025123611
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1046/j.1365-2052.2002.00899.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002968551
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1073/pnas.0706953104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022381201
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1074/jbc.m111.278374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024705623
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1074/jbc.m603454200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021413330
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1093/jhered/esg014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023274430
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1093/jhered/esq061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003550901
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1097/00029330-200809010-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077812078
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1097/fpc.0b013e328333a172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340777
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1111/j.1365-2052.2004.01148.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007403064
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1111/j.1365-2052.2004.01182.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026760562
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1111/j.1365-2052.2004.01191.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027778563
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1111/j.1365-2052.2005.01373.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045713029
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1111/j.1365-2052.2006.01414.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000339778
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1111/j.1365-2052.2006.01482.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037137030
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1111/j.1365-2052.2006.01488.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004980958
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1111/j.1365-2052.2009.01853.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011637258
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1111/j.1365-2052.2010.02049.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005052283
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1111/j.1365-2052.2010.02075.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004304381
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1111/j.1365-2052.2011.02279.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011200308
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1111/j.1439-0388.2006.00559.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032675890
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1111/j.1439-0388.2008.00770.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050345540
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1111/j.1751-1097.2011.00970.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034224964
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1111/jbg.12005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021588885
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1126/science.1325670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062475371
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1210/en.2008-0941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064249596
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1210/er.2006-0034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285872
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1210/er.2009-0037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285980
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1210/me.2009-0283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328383
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1371/journal.pone.0045731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020290807
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1530/joe-12-0501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049126091
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1677/jme-09-0161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001492591
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1677/jme.0.0320145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026332911
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.17221/169/2010-cjas schema:sameAs https://app.dimensions.ai/details/publication/pub.1100963234
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.2337/diabetes.54.suppl_2.s114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034782212
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.4141/cjas10074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006600978
    410 rdf:type schema:CreativeWork
    411 https://www.grid.ac/institutes/grid.410688.3 schema:alternateName University of Life Sciences in Poznań
    412 schema:name Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland
    413 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...