In vivo evaluation of bacterial cellulose/acrylic acid wound dressing hydrogel containing keratinocytes and fibroblasts for burn wounds View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Najwa Mohamad, Evelyn Yun Xi Loh, Mh Busra Fauzi, Min Hwei Ng, Mohd Cairul Iqbal Mohd Amin

ABSTRACT

The healing of wounds, including those from burns, currently exerts a burden on healthcare systems worldwide. Hydrogels are widely used as wound dressings and in the field of tissue engineering. The popularity of bacterial cellulose-based hydrogels has increased owing to their biocompatibility. Previous study demonstrated that bacterial cellulose/acrylic acid (BC/AA) hydrogel increased the healing rate of burn wound. This in vivo study using athymic mice has extended the use of BC/AA hydrogel by the addition of human epidermal keratinocytes and human dermal fibroblasts. The results showed that hydrogel loaded with cells produces the greatest acceleration on burn wound healing, followed by treatment with hydrogel alone, compared with the untreated group. The percentage wound reduction on day 13 in the mice treated with hydrogel loaded with cells (77.34 ± 6.21%) was significantly higher than that in the control-treated mice (64.79 ± 6.84%). Histological analysis, the expression of collagen type I via immunohistochemistry, and transmission electron microscopy indicated a greater deposition of collagen in the mice treated with hydrogel loaded with cells than in the mice administered other treatments. Therefore, the BC/AA hydrogel has promising application as a wound dressing and a cell carrier. More... »

PAGES

444-452

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13346-017-0475-3

DOI

http://dx.doi.org/10.1007/s13346-017-0475-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100191343

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29302918


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biomedical Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National University of Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.412113.4", 
          "name": [
            "Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohamad", 
        "givenName": "Najwa", 
        "id": "sg:person.01305730154.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305730154.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.412113.4", 
          "name": [
            "Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loh", 
        "givenName": "Evelyn Yun Xi", 
        "id": "sg:person.013545143414.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013545143414.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Kebangsaan Malaysia Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.240541.6", 
          "name": [
            "Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Kuala Lumpur, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fauzi", 
        "givenName": "Mh Busra", 
        "id": "sg:person.01275757464.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275757464.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Kebangsaan Malaysia Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.240541.6", 
          "name": [
            "Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Kuala Lumpur, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "Min Hwei", 
        "id": "sg:person.01063347357.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063347357.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.412113.4", 
          "name": [
            "Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohd Amin", 
        "givenName": "Mohd Cairul Iqbal", 
        "id": "sg:person.0622317520.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622317520.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jbm.b.33776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001759476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biortech.2016.02.071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003575712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2014.07.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006309225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.21210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006806574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bcr.0b013e318200ccb6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009615595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bcr.0b013e318200ccb6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009615595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bcr.0b013e318200ccb6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009615595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0961-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011165896", 
          "https://doi.org/10.1186/s13054-015-0961-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0961-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011165896", 
          "https://doi.org/10.1186/s13054-015-0961-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0961-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011165896", 
          "https://doi.org/10.1186/s13054-015-0961-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.4103/2321-3868.143616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011695336", 
          "https://doi.org/10.4103/2321-3868.143616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.carbpol.2012.10.071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012420939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bcr.0b013e31828cb249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015862308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bcr.0b013e31828cb249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015862308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejvs.2009.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018226487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.burns.2005.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018270463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ccid.s50046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020571952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asw.0000480556.78111.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022169605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asw.0000480556.78111.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022169605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1999.4543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024093703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0079-6700(01)00021-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025452370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0040978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025791295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2005.07.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027609565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.carbpol.2014.08.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027812120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030873761", 
          "https://doi.org/10.1038/nature07039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031545491", 
          "https://doi.org/10.1038/nrm1619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031545491", 
          "https://doi.org/10.1038/nrm1619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.carbpol.2014.10.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031896791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4236/cellbio.2012.12003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032136464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1445-1433.2004.03106.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033791305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.msec.2015.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034371911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2014.02.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034730323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4236/cellbio.2013.24027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037634013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2011.10.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037976620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcws.2011.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039890515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1874372201004010014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040872260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0142-9612(03)00340-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040955466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0142-9612(03)00340-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040955466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clindermatol.2006.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041476186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/wrr.12154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042118006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asw.0000445199.26874.9d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043736753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asw.0000445199.26874.9d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043736753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2005.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045596131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-409x(01)00239-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048496693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jid.5700786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051282892", 
          "https://doi.org/10.1038/sj.jid.5700786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1115973108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051391394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bcr.0b013e318148c9ac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052207645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bcr.0b013e318148c9ac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052207645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bcr.0b013e318148c9ac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052207645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/wound.2014.0551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059327946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12968/jowc.1999.8.8.25910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064824698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1387/ijdb.041802ad", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067190393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078459249", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082398525", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082538060", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15406/icpjl.2017.04.00085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084855735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15406/icpjl.2017.04.00085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084855735"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "The healing of wounds, including those from burns, currently exerts a burden on healthcare systems worldwide. Hydrogels are widely used as wound dressings and in the field of tissue engineering. The popularity of bacterial cellulose-based hydrogels has increased owing to their biocompatibility. Previous study demonstrated that bacterial cellulose/acrylic acid (BC/AA) hydrogel increased the healing rate of burn wound. This in vivo study using athymic mice has extended the use of BC/AA hydrogel by the addition of human epidermal keratinocytes and human dermal fibroblasts. The results showed that hydrogel loaded with cells produces the greatest acceleration on burn wound healing, followed by treatment with hydrogel alone, compared with the untreated group. The percentage wound reduction on day 13 in the mice treated with hydrogel loaded with cells (77.34\u2009\u00b1\u20096.21%) was significantly higher than that in the control-treated mice (64.79\u2009\u00b1\u20096.84%). Histological analysis, the expression of collagen type I via immunohistochemistry, and transmission electron microscopy indicated a greater deposition of collagen in the mice treated with hydrogel loaded with cells than in the mice administered other treatments. Therefore, the BC/AA hydrogel has promising application as a wound dressing and a cell carrier.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13346-017-0475-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1044116", 
        "issn": [
          "2190-393X", 
          "2190-3948"
        ], 
        "name": "Drug Delivery and Translational Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "In vivo evaluation of bacterial cellulose/acrylic acid wound dressing hydrogel containing keratinocytes and fibroblasts for burn wounds", 
    "pagination": "444-452", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4ca5bd1ec2c8fe116fd4eb6262cd5df0e912480904e4161b25eab06e66efc8d3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29302918"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101540061"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13346-017-0475-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100191343"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13346-017-0475-3", 
      "https://app.dimensions.ai/details/publication/pub.1100191343"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130830_00000005.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs13346-017-0475-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13346-017-0475-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13346-017-0475-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13346-017-0475-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13346-017-0475-3'


 

This table displays all metadata directly associated to this object as RDF triples.

237 TRIPLES      21 PREDICATES      74 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13346-017-0475-3 schema:about anzsrc-for:09
2 anzsrc-for:0903
3 schema:author N92ca383c6e0d470187dcfabf85e948d5
4 schema:citation sg:pub.10.1038/nature07039
5 sg:pub.10.1038/nrm1619
6 sg:pub.10.1038/sj.jid.5700786
7 sg:pub.10.1186/s13054-015-0961-2
8 sg:pub.10.4103/2321-3868.143616
9 https://app.dimensions.ai/details/publication/pub.1078459249
10 https://app.dimensions.ai/details/publication/pub.1082398525
11 https://app.dimensions.ai/details/publication/pub.1082538060
12 https://doi.org/10.1002/jbm.b.33776
13 https://doi.org/10.1002/jps.21210
14 https://doi.org/10.1006/excr.1999.4543
15 https://doi.org/10.1016/j.actbio.2011.10.005
16 https://doi.org/10.1016/j.biomaterials.2005.04.012
17 https://doi.org/10.1016/j.biomaterials.2005.07.035
18 https://doi.org/10.1016/j.biomaterials.2014.02.047
19 https://doi.org/10.1016/j.biomaterials.2014.07.048
20 https://doi.org/10.1016/j.biortech.2016.02.071
21 https://doi.org/10.1016/j.burns.2005.08.017
22 https://doi.org/10.1016/j.carbpol.2012.10.071
23 https://doi.org/10.1016/j.carbpol.2014.08.025
24 https://doi.org/10.1016/j.carbpol.2014.10.049
25 https://doi.org/10.1016/j.clindermatol.2006.09.007
26 https://doi.org/10.1016/j.ejvs.2009.01.007
27 https://doi.org/10.1016/j.jcws.2011.04.001
28 https://doi.org/10.1016/j.msec.2015.10.016
29 https://doi.org/10.1016/s0079-6700(01)00021-1
30 https://doi.org/10.1016/s0142-9612(03)00340-5
31 https://doi.org/10.1016/s0169-409x(01)00239-3
32 https://doi.org/10.1073/pnas.1115973108
33 https://doi.org/10.1089/wound.2014.0551
34 https://doi.org/10.1097/01.asw.0000445199.26874.9d
35 https://doi.org/10.1097/01.asw.0000480556.78111.e4
36 https://doi.org/10.1097/bcr.0b013e318148c9ac
37 https://doi.org/10.1097/bcr.0b013e318200ccb6
38 https://doi.org/10.1097/bcr.0b013e31828cb249
39 https://doi.org/10.1111/j.1445-1433.2004.03106.x
40 https://doi.org/10.1111/wrr.12154
41 https://doi.org/10.12968/jowc.1999.8.8.25910
42 https://doi.org/10.1371/journal.pone.0040978
43 https://doi.org/10.1387/ijdb.041802ad
44 https://doi.org/10.15406/icpjl.2017.04.00085
45 https://doi.org/10.2147/ccid.s50046
46 https://doi.org/10.2174/1874372201004010014
47 https://doi.org/10.4236/cellbio.2012.12003
48 https://doi.org/10.4236/cellbio.2013.24027
49 schema:datePublished 2019-04
50 schema:datePublishedReg 2019-04-01
51 schema:description The healing of wounds, including those from burns, currently exerts a burden on healthcare systems worldwide. Hydrogels are widely used as wound dressings and in the field of tissue engineering. The popularity of bacterial cellulose-based hydrogels has increased owing to their biocompatibility. Previous study demonstrated that bacterial cellulose/acrylic acid (BC/AA) hydrogel increased the healing rate of burn wound. This in vivo study using athymic mice has extended the use of BC/AA hydrogel by the addition of human epidermal keratinocytes and human dermal fibroblasts. The results showed that hydrogel loaded with cells produces the greatest acceleration on burn wound healing, followed by treatment with hydrogel alone, compared with the untreated group. The percentage wound reduction on day 13 in the mice treated with hydrogel loaded with cells (77.34 ± 6.21%) was significantly higher than that in the control-treated mice (64.79 ± 6.84%). Histological analysis, the expression of collagen type I via immunohistochemistry, and transmission electron microscopy indicated a greater deposition of collagen in the mice treated with hydrogel loaded with cells than in the mice administered other treatments. Therefore, the BC/AA hydrogel has promising application as a wound dressing and a cell carrier.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N7202d3b4412f48008ebf719f4a7bc976
56 Nb7e11cc036f648c7ae13fbeb9412ceae
57 sg:journal.1044116
58 schema:name In vivo evaluation of bacterial cellulose/acrylic acid wound dressing hydrogel containing keratinocytes and fibroblasts for burn wounds
59 schema:pagination 444-452
60 schema:productId N3a0526ca3f5d4f798a1e7dbf7a4779dc
61 N3dcb56a406cf4f8b860594c5ac2aacff
62 N4c26e2f108fe467e8aa9a4eeaac3a9af
63 N7ac395a742374ed2b4061abd7a38f263
64 N9b74e2007f53488b99bbb24124e939f1
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100191343
66 https://doi.org/10.1007/s13346-017-0475-3
67 schema:sdDatePublished 2019-04-11T14:02
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N16cfe546b3714acead61db7f7bac055c
70 schema:url https://link.springer.com/10.1007%2Fs13346-017-0475-3
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N16cfe546b3714acead61db7f7bac055c schema:name Springer Nature - SN SciGraph project
75 rdf:type schema:Organization
76 N20a73b01b3314ebba7137c88a28ec9e6 rdf:first sg:person.0622317520.36
77 rdf:rest rdf:nil
78 N3a0526ca3f5d4f798a1e7dbf7a4779dc schema:name doi
79 schema:value 10.1007/s13346-017-0475-3
80 rdf:type schema:PropertyValue
81 N3dcb56a406cf4f8b860594c5ac2aacff schema:name dimensions_id
82 schema:value pub.1100191343
83 rdf:type schema:PropertyValue
84 N4c26e2f108fe467e8aa9a4eeaac3a9af schema:name nlm_unique_id
85 schema:value 101540061
86 rdf:type schema:PropertyValue
87 N547f17e4022b4e3e8bb202dbf30c326b rdf:first sg:person.01063347357.06
88 rdf:rest N20a73b01b3314ebba7137c88a28ec9e6
89 N7202d3b4412f48008ebf719f4a7bc976 schema:volumeNumber 9
90 rdf:type schema:PublicationVolume
91 N7ac395a742374ed2b4061abd7a38f263 schema:name pubmed_id
92 schema:value 29302918
93 rdf:type schema:PropertyValue
94 N92ca383c6e0d470187dcfabf85e948d5 rdf:first sg:person.01305730154.33
95 rdf:rest Ncc211d0778254c7bb54132ed008abccd
96 N9b74e2007f53488b99bbb24124e939f1 schema:name readcube_id
97 schema:value 4ca5bd1ec2c8fe116fd4eb6262cd5df0e912480904e4161b25eab06e66efc8d3
98 rdf:type schema:PropertyValue
99 Nb7e11cc036f648c7ae13fbeb9412ceae schema:issueNumber 2
100 rdf:type schema:PublicationIssue
101 Nc9420f939dbe429884c3615718e4fd5b rdf:first sg:person.01275757464.09
102 rdf:rest N547f17e4022b4e3e8bb202dbf30c326b
103 Ncc211d0778254c7bb54132ed008abccd rdf:first sg:person.013545143414.31
104 rdf:rest Nc9420f939dbe429884c3615718e4fd5b
105 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
106 schema:name Engineering
107 rdf:type schema:DefinedTerm
108 anzsrc-for:0903 schema:inDefinedTermSet anzsrc-for:
109 schema:name Biomedical Engineering
110 rdf:type schema:DefinedTerm
111 sg:journal.1044116 schema:issn 2190-393X
112 2190-3948
113 schema:name Drug Delivery and Translational Research
114 rdf:type schema:Periodical
115 sg:person.01063347357.06 schema:affiliation https://www.grid.ac/institutes/grid.240541.6
116 schema:familyName Ng
117 schema:givenName Min Hwei
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063347357.06
119 rdf:type schema:Person
120 sg:person.01275757464.09 schema:affiliation https://www.grid.ac/institutes/grid.240541.6
121 schema:familyName Fauzi
122 schema:givenName Mh Busra
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275757464.09
124 rdf:type schema:Person
125 sg:person.01305730154.33 schema:affiliation https://www.grid.ac/institutes/grid.412113.4
126 schema:familyName Mohamad
127 schema:givenName Najwa
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305730154.33
129 rdf:type schema:Person
130 sg:person.013545143414.31 schema:affiliation https://www.grid.ac/institutes/grid.412113.4
131 schema:familyName Loh
132 schema:givenName Evelyn Yun Xi
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013545143414.31
134 rdf:type schema:Person
135 sg:person.0622317520.36 schema:affiliation https://www.grid.ac/institutes/grid.412113.4
136 schema:familyName Mohd Amin
137 schema:givenName Mohd Cairul Iqbal
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622317520.36
139 rdf:type schema:Person
140 sg:pub.10.1038/nature07039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030873761
141 https://doi.org/10.1038/nature07039
142 rdf:type schema:CreativeWork
143 sg:pub.10.1038/nrm1619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031545491
144 https://doi.org/10.1038/nrm1619
145 rdf:type schema:CreativeWork
146 sg:pub.10.1038/sj.jid.5700786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051282892
147 https://doi.org/10.1038/sj.jid.5700786
148 rdf:type schema:CreativeWork
149 sg:pub.10.1186/s13054-015-0961-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011165896
150 https://doi.org/10.1186/s13054-015-0961-2
151 rdf:type schema:CreativeWork
152 sg:pub.10.4103/2321-3868.143616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011695336
153 https://doi.org/10.4103/2321-3868.143616
154 rdf:type schema:CreativeWork
155 https://app.dimensions.ai/details/publication/pub.1078459249 schema:CreativeWork
156 https://app.dimensions.ai/details/publication/pub.1082398525 schema:CreativeWork
157 https://app.dimensions.ai/details/publication/pub.1082538060 schema:CreativeWork
158 https://doi.org/10.1002/jbm.b.33776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001759476
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1002/jps.21210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006806574
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1006/excr.1999.4543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024093703
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.actbio.2011.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037976620
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.biomaterials.2005.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045596131
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.biomaterials.2005.07.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027609565
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.biomaterials.2014.02.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034730323
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.biomaterials.2014.07.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006309225
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.biortech.2016.02.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003575712
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.burns.2005.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018270463
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.carbpol.2012.10.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012420939
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.carbpol.2014.08.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027812120
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.carbpol.2014.10.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031896791
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.clindermatol.2006.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041476186
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.ejvs.2009.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018226487
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.jcws.2011.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039890515
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.msec.2015.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034371911
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0079-6700(01)00021-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025452370
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0142-9612(03)00340-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040955466
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0169-409x(01)00239-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048496693
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1073/pnas.1115973108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051391394
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1089/wound.2014.0551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059327946
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/01.asw.0000445199.26874.9d schema:sameAs https://app.dimensions.ai/details/publication/pub.1043736753
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/01.asw.0000480556.78111.e4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022169605
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1097/bcr.0b013e318148c9ac schema:sameAs https://app.dimensions.ai/details/publication/pub.1052207645
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1097/bcr.0b013e318200ccb6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009615595
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1097/bcr.0b013e31828cb249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015862308
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1111/j.1445-1433.2004.03106.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033791305
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1111/wrr.12154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042118006
215 rdf:type schema:CreativeWork
216 https://doi.org/10.12968/jowc.1999.8.8.25910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064824698
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1371/journal.pone.0040978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025791295
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1387/ijdb.041802ad schema:sameAs https://app.dimensions.ai/details/publication/pub.1067190393
221 rdf:type schema:CreativeWork
222 https://doi.org/10.15406/icpjl.2017.04.00085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084855735
223 rdf:type schema:CreativeWork
224 https://doi.org/10.2147/ccid.s50046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020571952
225 rdf:type schema:CreativeWork
226 https://doi.org/10.2174/1874372201004010014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040872260
227 rdf:type schema:CreativeWork
228 https://doi.org/10.4236/cellbio.2012.12003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032136464
229 rdf:type schema:CreativeWork
230 https://doi.org/10.4236/cellbio.2013.24027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037634013
231 rdf:type schema:CreativeWork
232 https://www.grid.ac/institutes/grid.240541.6 schema:alternateName University Kebangsaan Malaysia Medical Centre
233 schema:name Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Kuala Lumpur, Malaysia
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.412113.4 schema:alternateName National University of Malaysia
236 schema:name Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
237 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...