Ontology type: schema:ScholarlyArticle Open Access: True
2014-04
AUTHORSMing Yang, Tao Yu, Joseph Wood, Ying-Ying Wang, Benjamin C. Tang, Qi Zeng, Brian W. Simons, Jie Fu, Chi-Mu Chuang, Samuel K. Lai, T.-C. Wu, Chien-Fu Hung, Justin Hanes
ABSTRACTIntraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed paclitaxel (PTX)-loaded microspheres composed of di-block copolymers of poly(ethylene glycol) and poly(sebacic acid) (PEG-PSA) for safe and sustained IP chemotherapy. PEG-PSA microspheres provided efficient loading (~ 13% w/w) and prolonged release (~ 13 days) of PTX. In a murine ovarian cancer model, a single dose of IP PTX/PEG-PSA particles effectively suppressed tumor growth for more than 40 days and extended the median survival time to 75 days compared to treatments with Taxol(®) (47 days) or IP placebo particles (34 days). IP PTX/PEG-PSA was well tolerated, with only minimal to mild inflammation. Our findings support PTX/PEG-PSA microspheres as a promising drug delivery platform for IP therapy of ovarian cancer, and potentially other metastatic peritoneal cancers. More... »
PAGES203-209
http://scigraph.springernature.com/pub.10.1007/s13346-013-0190-7
DOIhttp://dx.doi.org/10.1007/s13346-013-0190-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1029325896
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24816829
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, 21205, Baltimore, MD, USA",
"The Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, 21287, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Yang",
"givenName": "Ming",
"id": "sg:person.015653164557.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015653164557.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, 21205, Baltimore, MD, USA",
"The Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, 21287, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Yu",
"givenName": "Tao",
"id": "sg:person.01315024702.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315024702.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, 21205, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Wood",
"givenName": "Joseph",
"id": "sg:person.01166370331.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166370331.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, 21205, Baltimore, MD, USA",
"The Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, 21287, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Wang",
"givenName": "Ying-Ying",
"id": "sg:person.01207115265.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207115265.90"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts Institute of Technology",
"id": "https://www.grid.ac/institutes/grid.116068.8",
"name": [
"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, 21218, Baltimore, MD, USA",
"The Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, 21287, Baltimore, MD, USA",
"Koch Institute for Integrated Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave, 02139, Cambridge, MA, USA"
],
"type": "Organization"
},
"familyName": "Tang",
"givenName": "Benjamin C.",
"id": "sg:person.01331000127.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331000127.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, 21287, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Zeng",
"givenName": "Qi",
"id": "sg:person.01057651641.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057651641.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, 1550 Orleans Street, 21231, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Simons",
"givenName": "Brian W.",
"id": "sg:person.01102433101.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102433101.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, 21287, Baltimore, MD, USA",
"The Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, 21287, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Fu",
"givenName": "Jie",
"id": "sg:person.0711510302.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711510302.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, 21287, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Chuang",
"givenName": "Chi-Mu",
"id": "sg:person.0746776333.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746776333.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of North Carolina at Chapel Hill",
"id": "https://www.grid.ac/institutes/grid.10698.36",
"name": [
"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, 21218, Baltimore, MD, USA",
"Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Campus Box 7362, 27599, Chapel Hill, NC, USA"
],
"type": "Organization"
},
"familyName": "Lai",
"givenName": "Samuel K.",
"id": "sg:person.0612646147.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612646147.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, 21287, Baltimore, MD, USA",
"Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, 21287, Baltimore, MD, USA",
"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, 21287, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Wu",
"givenName": "T.-C.",
"id": "sg:person.012107260544.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012107260544.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, 21287, Baltimore, MD, USA",
"Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, 21287, Baltimore, MD, USA",
"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, 21287, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Hung",
"givenName": "Chien-Fu",
"id": "sg:person.014470015607.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014470015607.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, 21287, Baltimore, MD, USA",
"Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology, Johns Hopkins University, 3400 N Charles Street, 21218, Baltimore, MD, USA",
"The Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 N Broadway, 21287, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Hanes",
"givenName": "Justin",
"id": "sg:person.01231121350.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231121350.11"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.2217/fon.10.100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001436820"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2005.10.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001767435"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(03)01074-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005208755"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jconrel.2011.11.025",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005959105"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ygyno.2005.11.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007024090"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3322/caac.20107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009055747"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0142-9612(00)00073-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009745155"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.biomaterials.2009.07.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013368218"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0126(199901)48:1<47::aid-pi107>3.0.co;2-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013565315"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0126(199901)48:1<47::aid-pi107>3.0.co;2-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013565315"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbm.a.20101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014876457"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3302913",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017178463",
"https://doi.org/10.1038/sj.gt.3302913"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0142-9612(02)00182-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018358595"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0169-409x(02)00050-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019524134"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.biomaterials.2004.02.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020286395"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ygyno.2006.02.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020671213"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1586/14737140.8.7.1135",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022525277"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa052985",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025728214"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11095-009-0031-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025736500",
"https://doi.org/10.1007/s11095-009-0031-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11095-009-0031-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025736500",
"https://doi.org/10.1007/s11095-009-0031-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1367-5931(00)00227-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027863347"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jconrel.2011.12.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029677392"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0905998106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031731813"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0169-409x(02)00051-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031850906"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-0523",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034277248"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbm.820190806",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040029442"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.biomaterials.2011.07.067",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040706486"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1123",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040943590",
"https://doi.org/10.1038/nrc1123"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1123",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040943590",
"https://doi.org/10.1038/nrc1123"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.biomaterials.2009.09.033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040968284"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/10717541003762854",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043868948"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0169-409x(95)00026-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046259768"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/cr940351u",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048048943"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/cr940351u",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048048943"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1124/jpet.108.140095",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050834349"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/anie.200902672",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051926603"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.07-9574lsf",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052334407"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbm.a.32429",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053735369"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbm.a.32429",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053735369"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bm0200128",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055219623"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bm0200128",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055219623"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bm050648+",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055220717"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bm050648+",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055220717"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ma049853s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056190425"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ma049853s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056190425"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.8128245",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062652884"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082425415",
"type": "CreativeWork"
}
],
"datePublished": "2014-04",
"datePublishedReg": "2014-04-01",
"description": "Intraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed paclitaxel (PTX)-loaded microspheres composed of di-block copolymers of poly(ethylene glycol) and poly(sebacic acid) (PEG-PSA) for safe and sustained IP chemotherapy. PEG-PSA microspheres provided efficient loading (~ 13% w/w) and prolonged release (~ 13 days) of PTX. In a murine ovarian cancer model, a single dose of IP PTX/PEG-PSA particles effectively suppressed tumor growth for more than 40 days and extended the median survival time to 75 days compared to treatments with Taxol(\u00ae) (47 days) or IP placebo particles (34 days). IP PTX/PEG-PSA was well tolerated, with only minimal to mild inflammation. Our findings support PTX/PEG-PSA microspheres as a promising drug delivery platform for IP therapy of ovarian cancer, and potentially other metastatic peritoneal cancers. ",
"genre": "research_article",
"id": "sg:pub.10.1007/s13346-013-0190-7",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2699097",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2478134",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2440195",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1044116",
"issn": [
"2190-393X",
"2190-3948"
],
"name": "Drug Delivery and Translational Research",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "4"
}
],
"name": "Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model",
"pagination": "203-209",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"8bb3fe0ea943c745d977db274fef52bd66f67197e522fb7e3e32d3eb24429f77"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"24816829"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101540061"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s13346-013-0190-7"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1029325896"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s13346-013-0190-7",
"https://app.dimensions.ai/details/publication/pub.1029325896"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T15:54",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000522.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs13346-013-0190-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13346-013-0190-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13346-013-0190-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13346-013-0190-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13346-013-0190-7'
This table displays all metadata directly associated to this object as RDF triples.
294 TRIPLES
21 PREDICATES
68 URIs
21 LITERALS
9 BLANK NODES