Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04

AUTHORS

Ming Yang, Tao Yu, Joseph Wood, Ying-Ying Wang, Benjamin C. Tang, Qi Zeng, Brian W. Simons, Jie Fu, Chi-Mu Chuang, Samuel K. Lai, T.-C. Wu, Chien-Fu Hung, Justin Hanes

ABSTRACT

Intraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed paclitaxel (PTX)-loaded microspheres composed of di-block copolymers of poly(ethylene glycol) and poly(sebacic acid) (PEG-PSA) for safe and sustained IP chemotherapy. PEG-PSA microspheres provided efficient loading (~ 13% w/w) and prolonged release (~ 13 days) of PTX. In a murine ovarian cancer model, a single dose of IP PTX/PEG-PSA particles effectively suppressed tumor growth for more than 40 days and extended the median survival time to 75 days compared to treatments with Taxol(®) (47 days) or IP placebo particles (34 days). IP PTX/PEG-PSA was well tolerated, with only minimal to mild inflammation. Our findings support PTX/PEG-PSA microspheres as a promising drug delivery platform for IP therapy of ovarian cancer, and potentially other metastatic peritoneal cancers. More... »

PAGES

203-209

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13346-013-0190-7

DOI

http://dx.doi.org/10.1007/s13346-013-0190-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029325896

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24816829


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