MicroRNA-7 Protects Against Neurodegeneration Induced by α-Synuclein Preformed Fibrils in the Mouse Brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-10-25

AUTHORS

Jie Zhang, Mengyuan Zhao, Run Yan, Jun Liu, Santhosh Maddila, Eunsung Junn, M. Maral Mouradian

ABSTRACT

α-Synuclein is a key protein in the pathogenesis of Parkinson’s disease as it accumulates in fibrillar form in affected brain regions. Misfolded α-synuclein seeds recruit monomeric α-synuclein to form aggregates, which can spread to anatomically connected brain regions, a phenomenon that correlates with clinical disease progression. Thus, downregulating α-synuclein levels could reduce seeding and inhibit aggregate formation and propagation. We previously reported that microRNA-7 (miR-7) protects neuronal cells by downregulating α-synuclein expression through its effect on the 3′-untranslated region of SNCA mRNA; however, whether miR-7 blocks α-synuclein seeding and propagation in vivo remains unknown. Here, we induced miR-7 overexpression in the mouse striatum unilaterally by infusing adeno-associated virus 1 (AAV-miR-7) followed by inoculation with recombinant α-synuclein preformed fibrils (PFF) a month later. Compared with control mice injected with non-targeting AAV-miR-NT followed by PFF, AAV-miR-7 pre-injected mice exhibited lower levels of monomeric and high-molecular-weight α-synuclein species in the striatum, and reduced amount of phosphorylated α-synuclein in the striatum and in nigral dopamine neurons. Accordingly, AAV-miR-7-injected mice had less pronounced degeneration of the nigrostriatal pathway and better behavioral performance. The neuroinflammatory reaction to α-synuclein PFF inoculation was also significantly attenuated. These data suggest that miR-7 inhibits the formation and propagation of pathological α-synuclein and protects against neurodegeneration induced by PFF. Collectively, these findings support the potential of miR-7 as a disease modifying biologic agent for Parkinson’s disease and related α-synucleinopathies. More... »

PAGES

1-12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13311-021-01130-6

DOI

http://dx.doi.org/10.1007/s13311-021-01130-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142150436

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34697773


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jie", 
        "id": "sg:person.015621520405.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015621520405.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Mengyuan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Current address: Sanyou Biopharmaceuticals Co., Ltd., 3rd Floor, Building 6B-C, No. 188 Xinjunhuan Road, Minhang District, 201114, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA", 
            "Current address: Sanyou Biopharmaceuticals Co., Ltd., 3rd Floor, Building 6B-C, No. 188 Xinjunhuan Road, Minhang District, 201114, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yan", 
        "givenName": "Run", 
        "id": "sg:person.011370512425.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011370512425.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Jun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maddila", 
        "givenName": "Santhosh", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Junn", 
        "givenName": "Eunsung", 
        "id": "sg:person.01224212523.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224212523.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mouradian", 
        "givenName": "M. Maral", 
        "id": "sg:person.01024157374.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024157374.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nprot.2006.170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043367145", 
          "https://doi.org/10.1038/nprot.2006.170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/42166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029460877", 
          "https://doi.org/10.1038/42166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35081564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029825174", 
          "https://doi.org/10.1038/35081564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13024-020-00368-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1125461956", 
          "https://doi.org/10.1186/s13024-020-00368-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029954184", 
          "https://doi.org/10.1038/nm1746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40478-014-0156-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017557105", 
          "https://doi.org/10.1186/s40478-014-0156-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001799892", 
          "https://doi.org/10.1038/nrg1379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046792840", 
          "https://doi.org/10.1038/nprot.2007.153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13024-016-0094-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004558017", 
          "https://doi.org/10.1186/s13024-016-0094-3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-10-25", 
    "datePublishedReg": "2021-10-25", 
    "description": "Abstract\u03b1-Synuclein is a key protein in the pathogenesis of Parkinson\u2019s disease as it accumulates in fibrillar form in affected brain regions. Misfolded \u03b1-synuclein seeds recruit monomeric \u03b1-synuclein to form aggregates, which can spread to anatomically connected brain regions, a phenomenon that correlates with clinical disease progression. Thus, downregulating \u03b1-synuclein levels could reduce seeding and inhibit aggregate formation and propagation. We previously reported that microRNA-7 (miR-7) protects neuronal cells by downregulating \u03b1-synuclein expression through its effect on the 3\u2032-untranslated region of SNCA mRNA; however, whether miR-7 blocks \u03b1-synuclein seeding and propagation in vivo remains unknown. Here, we induced miR-7 overexpression in the mouse striatum unilaterally by infusing adeno-associated virus 1 (AAV-miR-7) followed by inoculation with recombinant \u03b1-synuclein preformed fibrils (PFF) a month later. Compared with control mice injected with non-targeting AAV-miR-NT followed by PFF, AAV-miR-7 pre-injected mice exhibited lower levels of monomeric and high-molecular-weight \u03b1-synuclein species in the striatum, and reduced amount of phosphorylated \u03b1-synuclein in the striatum and in nigral dopamine neurons. Accordingly, AAV-miR-7-injected mice had less pronounced degeneration of the nigrostriatal pathway and better behavioral performance. The neuroinflammatory reaction to \u03b1-synuclein PFF inoculation was also significantly attenuated. These data suggest that miR-7 inhibits the formation and propagation of pathological \u03b1-synuclein and protects against neurodegeneration induced by PFF. Collectively, these findings support the potential of miR-7 as a disease modifying biologic agent for Parkinson\u2019s disease and related \u03b1-synucleinopathies.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s13311-021-01130-6", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6803407", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2562801", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9292605", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1294839", 
        "issn": [
          "1933-7213", 
          "1878-7479"
        ], 
        "name": "Neurotherapeutics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }
    ], 
    "keywords": [
      "Parkinson's disease", 
      "brain regions", 
      "nigral dopamine neurons", 
      "clinical disease progression", 
      "affected brain regions", 
      "miR-7", 
      "miR-7 overexpression", 
      "Preformed Fibrils", 
      "neuroinflammatory reaction", 
      "biologic agents", 
      "synuclein levels", 
      "nigrostriatal pathway", 
      "control mice", 
      "pronounced degeneration", 
      "disease progression", 
      "dopamine neurons", 
      "synuclein expression", 
      "mouse striatum", 
      "synuclein seeding", 
      "synuclein species", 
      "mouse brain", 
      "neuronal cells", 
      "disease", 
      "Abstract\u03b1-Synuclein", 
      "striatum", 
      "better behavioral performance", 
      "virus 1", 
      "SNCA-mRNA", 
      "mice", 
      "synuclein", 
      "behavioral performance", 
      "protects", 
      "neurodegeneration", 
      "fibrillar form", 
      "key proteins", 
      "low levels", 
      "pathogenesis", 
      "synucleinopathies", 
      "PFF", 
      "neurons", 
      "degeneration", 
      "progression", 
      "brain", 
      "months", 
      "inoculation", 
      "levels", 
      "vivo", 
      "adeno", 
      "overexpression", 
      "mRNA", 
      "cells", 
      "expression", 
      "agents", 
      "findings", 
      "pathway", 
      "fibrils", 
      "protein", 
      "effect", 
      "weight \u03b1", 
      "aggregate formation", 
      "region", 
      "data", 
      "seeding", 
      "recruits", 
      "potential", 
      "formation", 
      "NT", 
      "form aggregates", 
      "reaction", 
      "amount", 
      "form", 
      "aggregates", 
      "phenomenon", 
      "species", 
      "performance", 
      "propagation", 
      "block \u03b1", 
      "synuclein seeds recruit", 
      "seeds recruit", 
      "miR-7 blocks \u03b1", 
      "non-targeting AAV-miR", 
      "AAV-miR", 
      "AAV-miR-7 pre-injected mice", 
      "pre-injected mice", 
      "AAV-miR-7-injected mice", 
      "synuclein PFF inoculation", 
      "PFF inoculation", 
      "MicroRNA-7 Protects", 
      "Synuclein Preformed Fibrils"
    ], 
    "name": "MicroRNA-7 Protects Against Neurodegeneration Induced by \u03b1-Synuclein Preformed Fibrils in the Mouse Brain", 
    "pagination": "1-12", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1142150436"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13311-021-01130-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34697773"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13311-021-01130-6", 
      "https://app.dimensions.ai/details/publication/pub.1142150436"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T19:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_919.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s13311-021-01130-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13311-021-01130-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13311-021-01130-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13311-021-01130-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13311-021-01130-6'


 

This table displays all metadata directly associated to this object as RDF triples.

230 TRIPLES      22 PREDICATES      122 URIs      105 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13311-021-01130-6 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Na9060855c1ce4876874e546fe079e3fb
4 schema:citation sg:pub.10.1038/35081564
5 sg:pub.10.1038/42166
6 sg:pub.10.1038/nm1746
7 sg:pub.10.1038/nprot.2006.170
8 sg:pub.10.1038/nprot.2007.153
9 sg:pub.10.1038/nrg1379
10 sg:pub.10.1186/s13024-016-0094-3
11 sg:pub.10.1186/s13024-020-00368-6
12 sg:pub.10.1186/s40478-014-0156-0
13 schema:datePublished 2021-10-25
14 schema:datePublishedReg 2021-10-25
15 schema:description Abstractα-Synuclein is a key protein in the pathogenesis of Parkinson’s disease as it accumulates in fibrillar form in affected brain regions. Misfolded α-synuclein seeds recruit monomeric α-synuclein to form aggregates, which can spread to anatomically connected brain regions, a phenomenon that correlates with clinical disease progression. Thus, downregulating α-synuclein levels could reduce seeding and inhibit aggregate formation and propagation. We previously reported that microRNA-7 (miR-7) protects neuronal cells by downregulating α-synuclein expression through its effect on the 3′-untranslated region of SNCA mRNA; however, whether miR-7 blocks α-synuclein seeding and propagation in vivo remains unknown. Here, we induced miR-7 overexpression in the mouse striatum unilaterally by infusing adeno-associated virus 1 (AAV-miR-7) followed by inoculation with recombinant α-synuclein preformed fibrils (PFF) a month later. Compared with control mice injected with non-targeting AAV-miR-NT followed by PFF, AAV-miR-7 pre-injected mice exhibited lower levels of monomeric and high-molecular-weight α-synuclein species in the striatum, and reduced amount of phosphorylated α-synuclein in the striatum and in nigral dopamine neurons. Accordingly, AAV-miR-7-injected mice had less pronounced degeneration of the nigrostriatal pathway and better behavioral performance. The neuroinflammatory reaction to α-synuclein PFF inoculation was also significantly attenuated. These data suggest that miR-7 inhibits the formation and propagation of pathological α-synuclein and protects against neurodegeneration induced by PFF. Collectively, these findings support the potential of miR-7 as a disease modifying biologic agent for Parkinson’s disease and related α-synucleinopathies.
16 schema:genre article
17 schema:inLanguage en
18 schema:isAccessibleForFree false
19 schema:isPartOf sg:journal.1294839
20 schema:keywords AAV-miR
21 AAV-miR-7 pre-injected mice
22 AAV-miR-7-injected mice
23 Abstractα-Synuclein
24 MicroRNA-7 Protects
25 NT
26 PFF
27 PFF inoculation
28 Parkinson's disease
29 Preformed Fibrils
30 SNCA-mRNA
31 Synuclein Preformed Fibrils
32 adeno
33 affected brain regions
34 agents
35 aggregate formation
36 aggregates
37 amount
38 behavioral performance
39 better behavioral performance
40 biologic agents
41 block α
42 brain
43 brain regions
44 cells
45 clinical disease progression
46 control mice
47 data
48 degeneration
49 disease
50 disease progression
51 dopamine neurons
52 effect
53 expression
54 fibrillar form
55 fibrils
56 findings
57 form
58 form aggregates
59 formation
60 inoculation
61 key proteins
62 levels
63 low levels
64 mRNA
65 miR-7
66 miR-7 blocks α
67 miR-7 overexpression
68 mice
69 months
70 mouse brain
71 mouse striatum
72 neurodegeneration
73 neuroinflammatory reaction
74 neuronal cells
75 neurons
76 nigral dopamine neurons
77 nigrostriatal pathway
78 non-targeting AAV-miR
79 overexpression
80 pathogenesis
81 pathway
82 performance
83 phenomenon
84 potential
85 pre-injected mice
86 progression
87 pronounced degeneration
88 propagation
89 protects
90 protein
91 reaction
92 recruits
93 region
94 seeding
95 seeds recruit
96 species
97 striatum
98 synuclein
99 synuclein PFF inoculation
100 synuclein expression
101 synuclein levels
102 synuclein seeding
103 synuclein seeds recruit
104 synuclein species
105 synucleinopathies
106 virus 1
107 vivo
108 weight α
109 schema:name MicroRNA-7 Protects Against Neurodegeneration Induced by α-Synuclein Preformed Fibrils in the Mouse Brain
110 schema:pagination 1-12
111 schema:productId N112b793295fb4626ad7ed6e38d7c669a
112 N241aad136f53493382ff972dd09fd399
113 N64fe066553bc4e2d8208162d2ef8e802
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1142150436
115 https://doi.org/10.1007/s13311-021-01130-6
116 schema:sdDatePublished 2022-01-01T19:01
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher N4ea4ace9c6ad4db7ad0a338286148e33
119 schema:url https://doi.org/10.1007/s13311-021-01130-6
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N112b793295fb4626ad7ed6e38d7c669a schema:name dimensions_id
124 schema:value pub.1142150436
125 rdf:type schema:PropertyValue
126 N1531ecbd4d4342cd842e119313d2284c schema:affiliation grid-institutes:grid.430387.b
127 schema:familyName Zhao
128 schema:givenName Mengyuan
129 rdf:type schema:Person
130 N1a128d593434424e867f5c67dc4ac34c rdf:first N4d7ad8f099f44f30800fb795f2aa3c60
131 rdf:rest N4d86b880cd344a1798786b8669cb59f5
132 N241aad136f53493382ff972dd09fd399 schema:name pubmed_id
133 schema:value 34697773
134 rdf:type schema:PropertyValue
135 N34f4f09913d24cf09527dc55b326b5d8 rdf:first sg:person.011370512425.14
136 rdf:rest N6df71bfafcce4064ae4609cfde66c7c4
137 N48756a602c7f41f9a1d69197e2f09c02 rdf:first N1531ecbd4d4342cd842e119313d2284c
138 rdf:rest N34f4f09913d24cf09527dc55b326b5d8
139 N4d7ad8f099f44f30800fb795f2aa3c60 schema:affiliation grid-institutes:grid.430387.b
140 schema:familyName Maddila
141 schema:givenName Santhosh
142 rdf:type schema:Person
143 N4d86b880cd344a1798786b8669cb59f5 rdf:first sg:person.01224212523.77
144 rdf:rest Nff378b27eea84df59a56eb12d633f2c8
145 N4ea4ace9c6ad4db7ad0a338286148e33 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N64fe066553bc4e2d8208162d2ef8e802 schema:name doi
148 schema:value 10.1007/s13311-021-01130-6
149 rdf:type schema:PropertyValue
150 N6df71bfafcce4064ae4609cfde66c7c4 rdf:first Nccd0a9fe79474752b87602214df9b80b
151 rdf:rest N1a128d593434424e867f5c67dc4ac34c
152 Na9060855c1ce4876874e546fe079e3fb rdf:first sg:person.015621520405.31
153 rdf:rest N48756a602c7f41f9a1d69197e2f09c02
154 Nccd0a9fe79474752b87602214df9b80b schema:affiliation grid-institutes:grid.430387.b
155 schema:familyName Liu
156 schema:givenName Jun
157 rdf:type schema:Person
158 Nff378b27eea84df59a56eb12d633f2c8 rdf:first sg:person.01024157374.05
159 rdf:rest rdf:nil
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
164 schema:name Neurosciences
165 rdf:type schema:DefinedTerm
166 sg:grant.2562801 http://pending.schema.org/fundedItem sg:pub.10.1007/s13311-021-01130-6
167 rdf:type schema:MonetaryGrant
168 sg:grant.6803407 http://pending.schema.org/fundedItem sg:pub.10.1007/s13311-021-01130-6
169 rdf:type schema:MonetaryGrant
170 sg:grant.9292605 http://pending.schema.org/fundedItem sg:pub.10.1007/s13311-021-01130-6
171 rdf:type schema:MonetaryGrant
172 sg:journal.1294839 schema:issn 1878-7479
173 1933-7213
174 schema:name Neurotherapeutics
175 schema:publisher Springer Nature
176 rdf:type schema:Periodical
177 sg:person.01024157374.05 schema:affiliation grid-institutes:grid.430387.b
178 schema:familyName Mouradian
179 schema:givenName M. Maral
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024157374.05
181 rdf:type schema:Person
182 sg:person.011370512425.14 schema:affiliation grid-institutes:None
183 schema:familyName Yan
184 schema:givenName Run
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011370512425.14
186 rdf:type schema:Person
187 sg:person.01224212523.77 schema:affiliation grid-institutes:grid.430387.b
188 schema:familyName Junn
189 schema:givenName Eunsung
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224212523.77
191 rdf:type schema:Person
192 sg:person.015621520405.31 schema:affiliation grid-institutes:grid.430387.b
193 schema:familyName Zhang
194 schema:givenName Jie
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015621520405.31
196 rdf:type schema:Person
197 sg:pub.10.1038/35081564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029825174
198 https://doi.org/10.1038/35081564
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/42166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029460877
201 https://doi.org/10.1038/42166
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/nm1746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029954184
204 https://doi.org/10.1038/nm1746
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/nprot.2006.170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043367145
207 https://doi.org/10.1038/nprot.2006.170
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/nprot.2007.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046792840
210 https://doi.org/10.1038/nprot.2007.153
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/nrg1379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001799892
213 https://doi.org/10.1038/nrg1379
214 rdf:type schema:CreativeWork
215 sg:pub.10.1186/s13024-016-0094-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004558017
216 https://doi.org/10.1186/s13024-016-0094-3
217 rdf:type schema:CreativeWork
218 sg:pub.10.1186/s13024-020-00368-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125461956
219 https://doi.org/10.1186/s13024-020-00368-6
220 rdf:type schema:CreativeWork
221 sg:pub.10.1186/s40478-014-0156-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017557105
222 https://doi.org/10.1186/s40478-014-0156-0
223 rdf:type schema:CreativeWork
224 grid-institutes:None schema:alternateName Current address: Sanyou Biopharmaceuticals Co., Ltd., 3rd Floor, Building 6B-C, No. 188 Xinjunhuan Road, Minhang District, 201114, Shanghai, China
225 schema:name Current address: Sanyou Biopharmaceuticals Co., Ltd., 3rd Floor, Building 6B-C, No. 188 Xinjunhuan Road, Minhang District, 201114, Shanghai, China
226 RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA
227 rdf:type schema:Organization
228 grid-institutes:grid.430387.b schema:alternateName RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA
229 schema:name RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers - Robert Wood Johnson Medical School, 683 Hoes Lane West, Room 180, 08854, Piscataway, NJ, USA
230 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...