Thymectomy and Risk of Generalization in Patients with Ocular Myasthenia Gravis: A Multicenter Retrospective Cohort Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-10-08

AUTHORS

Huanhuan Li, Zhe Ruan, Feng Gao, Hongyu Zhou, Rongjing Guo, Chao Sun, Quan Xu, Qiang Lu, Yongan Zhou, Zhengwei Zhao, Liping Yu, Songdi Wu, Tao Lei, Ting Gao, Yonglan Tang, Chunhong Li, Feiyan Huo, Ying Zhu, Jie Sun, Baoli Tang, Min Zhang, Yanwu Gao, Xiaodan Lu, Zhuyi Li, Ting Chang

ABSTRACT

This study aims to investigate the association between thymectomy and the risk of generalization in patients with ocular myasthenia gravis (MG). Data on patients with ocular MG from seven neurological centers in China were retrospectively reviewed. Ocular MG naïve to immunotherapy was categorized according to whether thymectomy was performed (thymectomized group vs. nonsurgical group). Patients in the thymectomized group all underwent surgery within 2 years since ocular symptom onset. The main outcome measure was the generalization. The follow-up period was defined from the date of ocular symptom onset to the date of generalization confirmation, immunotherapy initiation, or last follow-up (defined as 60 months). Of 519 eligible patients (mean [SD] age, 48.7 [15.2] years, 46.6% women), 31 (23.7%) of 131 generalized in the thymectomized group and 122 (31.4%) of 388 did in the nonsurgical group during a median follow-up of 19 months (IQR 8.0–50.0). Thymectomy was independently associated with reduced generalization risk (adjusted HR 0.41, 95% CI 0.25–0.66, P < 0.001). Multivariable stratified analysis also verified this association across the subgroups. Kaplan–Meier curves showed that the 5-year cumulative rate was significantly lower in the thymectomized group than in the nonsurgical group. To conclude, thymectomy may be considered effective in modifying the progression from ocular to generalized MG irrespective of thymoma. More... »

PAGES

1-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13311-021-01129-z

DOI

http://dx.doi.org/10.1007/s13311-021-01129-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1141746316

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34625864


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