Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer’s ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Barbara R. Cardoso, Blaine R. Roberts, Charles B. Malpas, Lucy Vivash, Sila Genc, Michael M. Saling, Patricia Desmond, Christopher Steward, Rodney J. Hicks, Jason Callahan, Amy Brodtmann, Steven Collins, Stephen Macfarlane, Niall M Corcoran, Christopher M. Hovens, Dennis Velakoulis, Terence J. O’Brien, Dominic J. Hare, Ashley I. Bush

ABSTRACT

Insufficient supply of selenium to antioxidant enzymes in the brain may contribute to Alzheimer's disease (AD) pathophysiology; therefore, oral supplementation may potentially slow neurodegeneration. We examined selenium and selenoproteins in serum and cerebrospinal fluid (CSF) from a dual-dose 24-week randomized controlled trial of sodium selenate in AD patients, to assess tolerability, and efficacy of selenate in modulating selenium concentration in the central nervous system (CNS). A pilot study of 40 AD cases was randomized to placebo, nutritional (0.32 mg sodium selenate, 3 times daily), or supranutritional (10 mg, 3 times daily) groups. We measured total selenium, selenoproteins, and inorganic selenium levels, in serum and CSF, and compared against cognitive outcomes. Supranutritional selenium supplementation was well tolerated and yielded a significant (p < 0.001) but variable (95% CI = 13.4-24.8 μg/L) increase in CSF selenium, distributed across selenoproteins and inorganic species. Reclassifying subjects as either responsive or non-responsive based on elevation in CSF selenium concentrations revealed that responsive group did not deteriorate in Mini-Mental Status Examination (MMSE) as non-responsive group (p = 0.03). Pooled analysis of all samples revealed that CSF selenium could predict change in MMSE performance (Spearman's rho = 0.403; p = 0.023). High-dose sodium selenate supplementation is well tolerated and can modulate CNS selenium concentration, although individual variation in selenium metabolism must be considered to optimize potential benefits in AD. The Vel002 study is listed on the Australian and New Zealand Clinical Trials Registry ( http://www.anzctr.org.au /), ID: ACTRN12611001200976. More... »

PAGES

192-202

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13311-018-0662-z

DOI

http://dx.doi.org/10.1007/s13311-018-0662-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106945903

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30215171


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Deakin University", 
          "id": "https://www.grid.ac/institutes/grid.1021.2", 
          "name": [
            "Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cardoso", 
        "givenName": "Barbara R.", 
        "id": "sg:person.01166724545.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166724545.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, 3052, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roberts", 
        "givenName": "Blaine R.", 
        "id": "sg:person.0676016754.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676016754.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia", 
            "Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia", 
            "Developmental Imaging, Murdoch Children\u2019s Research Institute, Melbourne, Victoria, Australia", 
            "Departments of Neuroscience and Neurology, The Central Clinical School and The Alfred Hospital, Monash University, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malpas", 
        "givenName": "Charles B.", 
        "id": "sg:person.0753745175.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753745175.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia", 
            "Departments of Neuroscience and Neurology, The Central Clinical School and The Alfred Hospital, Monash University, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vivash", 
        "givenName": "Lucy", 
        "id": "sg:person.01231620554.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231620554.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Developmental Imaging, Murdoch Children\u2019s Research Institute, Melbourne, Victoria, Australia", 
            "Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Genc", 
        "givenName": "Sila", 
        "id": "sg:person.01167327663.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167327663.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saling", 
        "givenName": "Michael M.", 
        "id": "sg:person.0711243243.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711243243.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Desmond", 
        "givenName": "Patricia", 
        "id": "sg:person.0631042656.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631042656.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steward", 
        "givenName": "Christopher", 
        "id": "sg:person.0657640420.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657640420.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia", 
            "Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hicks", 
        "givenName": "Rodney J.", 
        "id": "sg:person.01121233254.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121233254.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Callahan", 
        "givenName": "Jason", 
        "id": "sg:person.0616621550.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616621550.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, 3052, Parkville, Victoria, Australia", 
            "Eastern Cognitive Disorders Clinic, Department of Neurology, Eastern Health, Monash University, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brodtmann", 
        "givenName": "Amy", 
        "id": "sg:person.0672444704.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672444704.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Vincent's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413105.2", 
          "name": [
            "Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia", 
            "Department of Clinical Neurosciences and Neurological Research, St Vincent\u2019s Hospital, Fitzroy, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Collins", 
        "givenName": "Steven", 
        "id": "sg:person.0613350466.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613350466.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Caulfield Hospital, Alfred Health, Caulfield, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Macfarlane", 
        "givenName": "Stephen", 
        "id": "sg:person.01120750744.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120750744.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Melbourne Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416153.4", 
          "name": [
            "Department of Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corcoran", 
        "givenName": "Niall M", 
        "id": "sg:person.01236431544.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236431544.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Melbourne Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416153.4", 
          "name": [
            "Department of Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hovens", 
        "givenName": "Christopher M.", 
        "id": "sg:person.01063350511.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063350511.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Velakoulis", 
        "givenName": "Dennis", 
        "id": "sg:person.01057416603.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057416603.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia", 
            "Departments of Neuroscience and Neurology, The Central Clinical School and The Alfred Hospital, Monash University, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Brien", 
        "givenName": "Terence J.", 
        "id": "sg:person.01214124212.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214124212.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, 3052, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hare", 
        "givenName": "Dominic J.", 
        "id": "sg:person.01115003444.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115003444.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, 3052, Parkville, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bush", 
        "givenName": "Ashley I.", 
        "id": "sg:person.012630724662.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012630724662.81"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00216-012-6294-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001998959", 
          "https://doi.org/10.1007/s00216-012-6294-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00394-014-0829-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002036375", 
          "https://doi.org/10.1007/s00394-014-0829-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1009038107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002733944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd1330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003102113", 
          "https://doi.org/10.1038/nrd1330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd1330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003102113", 
          "https://doi.org/10.1038/nrd1330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003167107", 
          "https://doi.org/10.1038/nature05292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003167107", 
          "https://doi.org/10.1038/nature05292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003167107", 
          "https://doi.org/10.1038/nature05292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)61452-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005650332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2016.196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008529431", 
          "https://doi.org/10.1038/mp.2016.196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3791/53737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013734000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awv053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014024756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.talanta.2016.02.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014548248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2009.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014678434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kwk073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015522188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jocn.2010.04.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018501852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/a904024b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019241970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainresrev.2004.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021398364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.1416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022089224", 
          "https://doi.org/10.1038/nchembio.1416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.34.7.939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024664401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c5mt00075k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027608861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2013.11.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027673951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtemb.2015.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028296840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-5415.2000.tb02603.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030207195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007114515003499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031569969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-014-1380-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031880818", 
          "https://doi.org/10.1007/s00204-014-1380-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.talanta.2006.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032552678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.talanta.2013.02.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033127866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.03.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036616855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinternmed.2009.495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036765245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c3mt00227f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038366038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejcn.1601800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039729593", 
          "https://doi.org/10.1038/sj.ejcn.1601800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejcn.1601800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039729593", 
          "https://doi.org/10.1038/sj.ejcn.1601800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2013.05.1771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042416332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/nu5041024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044618633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2005.085332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044885685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007114509992832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052057681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007114509992832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052057681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/ajcn.2010.29642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053347790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic800310j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055582858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic800310j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055582858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2006.1363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059230313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-160544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071127407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-2011-110414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078398850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080191144", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-160622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083751086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaneurol.2016.5778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084005989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtemb.2017.04.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085137691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acschemneuro.7b00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085322114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2017.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090662078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trac.2017.09.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091892993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.09.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092117016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2018.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101039451"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01", 
    "datePublishedReg": "2019-01-01", 
    "description": "Insufficient supply of selenium to antioxidant enzymes in the brain may contribute to Alzheimer's disease (AD) pathophysiology; therefore, oral supplementation may potentially slow neurodegeneration. We examined selenium and selenoproteins in serum and cerebrospinal fluid (CSF) from a dual-dose 24-week randomized controlled trial of sodium selenate in AD patients, to assess tolerability, and efficacy of selenate in modulating selenium concentration in the central nervous system (CNS). A pilot study of 40 AD cases was randomized to placebo, nutritional (0.32\u00a0mg sodium selenate, 3 times daily), or supranutritional (10\u00a0mg, 3 times daily) groups. We measured total selenium, selenoproteins, and inorganic selenium levels, in serum and CSF, and compared against cognitive outcomes. Supranutritional selenium supplementation was well tolerated and yielded a significant (p\u2009<\u20090.001) but variable (95% CI\u2009=\u200913.4-24.8\u00a0\u03bcg/L) increase in CSF selenium, distributed across selenoproteins and inorganic species. Reclassifying subjects as either responsive or non-responsive based on elevation in CSF selenium concentrations revealed that responsive group did not deteriorate in Mini-Mental Status Examination (MMSE) as non-responsive group (p\u2009=\u20090.03). Pooled analysis of all samples revealed that CSF selenium could predict change in MMSE performance (Spearman's rho\u2009=\u20090.403; p\u2009=\u20090.023). High-dose sodium selenate supplementation is well tolerated and can modulate CNS selenium concentration, although individual variation in selenium metabolism must be considered to optimize potential benefits in AD. The Vel002 study is listed on the Australian and New Zealand Clinical Trials Registry ( http://www.anzctr.org.au /), ID: ACTRN12611001200976.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13311-018-0662-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7877874", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7879113", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7875846", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7874853", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7874214", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1294839", 
        "issn": [
          "1933-7213", 
          "1878-7479"
        ], 
        "name": "Neurotherapeutics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer\u2019s Disease", 
    "pagination": "192-202", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bbafff539f6d6fe0fae214782aa9067e05575b439b2392113cdb7003e2683275"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30215171"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101290381"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13311-018-0662-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106945903"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13311-018-0662-z", 
      "https://app.dimensions.ai/details/publication/pub.1106945903"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54301_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs13311-018-0662-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13311-018-0662-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13311-018-0662-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13311-018-0662-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13311-018-0662-z'


 

This table displays all metadata directly associated to this object as RDF triples.

390 TRIPLES      21 PREDICATES      76 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13311-018-0662-z schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N87d3342d628b417b9041e6f33fbfdacc
4 schema:citation sg:pub.10.1007/s00204-014-1380-x
5 sg:pub.10.1007/s00216-012-6294-y
6 sg:pub.10.1007/s00394-014-0829-2
7 sg:pub.10.1038/mp.2016.196
8 sg:pub.10.1038/nature05292
9 sg:pub.10.1038/nchembio.1416
10 sg:pub.10.1038/nrd1330
11 sg:pub.10.1038/sj.ejcn.1601800
12 https://app.dimensions.ai/details/publication/pub.1080191144
13 https://doi.org/10.1001/archinternmed.2009.495
14 https://doi.org/10.1001/jamaneurol.2016.5778
15 https://doi.org/10.1016/j.brainresrev.2004.03.004
16 https://doi.org/10.1016/j.cell.2012.03.042
17 https://doi.org/10.1016/j.cell.2017.09.021
18 https://doi.org/10.1016/j.expneurol.2017.07.006
19 https://doi.org/10.1016/j.freeradbiomed.2009.03.008
20 https://doi.org/10.1016/j.freeradbiomed.2018.02.015
21 https://doi.org/10.1016/j.jalz.2013.05.1771
22 https://doi.org/10.1016/j.jocn.2010.04.020
23 https://doi.org/10.1016/j.jtemb.2015.07.005
24 https://doi.org/10.1016/j.jtemb.2017.04.005
25 https://doi.org/10.1016/j.talanta.2006.08.018
26 https://doi.org/10.1016/j.talanta.2013.02.014
27 https://doi.org/10.1016/j.talanta.2016.02.035
28 https://doi.org/10.1016/j.toxlet.2013.11.016
29 https://doi.org/10.1016/j.trac.2017.09.017
30 https://doi.org/10.1016/s0140-6736(11)61452-9
31 https://doi.org/10.1017/s0007114509992832
32 https://doi.org/10.1017/s0007114515003499
33 https://doi.org/10.1021/acschemneuro.7b00014
34 https://doi.org/10.1021/ic800310j
35 https://doi.org/10.1039/a904024b
36 https://doi.org/10.1039/c3mt00227f
37 https://doi.org/10.1039/c5mt00075k
38 https://doi.org/10.1073/pnas.1009038107
39 https://doi.org/10.1089/ars.2006.1363
40 https://doi.org/10.1093/aje/kwk073
41 https://doi.org/10.1093/brain/awv053
42 https://doi.org/10.1111/j.1532-5415.2000.tb02603.x
43 https://doi.org/10.1136/jnnp.2005.085332
44 https://doi.org/10.1212/wnl.34.7.939
45 https://doi.org/10.3233/jad-160544
46 https://doi.org/10.3233/jad-160622
47 https://doi.org/10.3233/jad-2011-110414
48 https://doi.org/10.3390/nu5041024
49 https://doi.org/10.3791/53737
50 https://doi.org/10.3945/ajcn.2010.29642
51 schema:datePublished 2019-01
52 schema:datePublishedReg 2019-01-01
53 schema:description Insufficient supply of selenium to antioxidant enzymes in the brain may contribute to Alzheimer's disease (AD) pathophysiology; therefore, oral supplementation may potentially slow neurodegeneration. We examined selenium and selenoproteins in serum and cerebrospinal fluid (CSF) from a dual-dose 24-week randomized controlled trial of sodium selenate in AD patients, to assess tolerability, and efficacy of selenate in modulating selenium concentration in the central nervous system (CNS). A pilot study of 40 AD cases was randomized to placebo, nutritional (0.32 mg sodium selenate, 3 times daily), or supranutritional (10 mg, 3 times daily) groups. We measured total selenium, selenoproteins, and inorganic selenium levels, in serum and CSF, and compared against cognitive outcomes. Supranutritional selenium supplementation was well tolerated and yielded a significant (p < 0.001) but variable (95% CI = 13.4-24.8 μg/L) increase in CSF selenium, distributed across selenoproteins and inorganic species. Reclassifying subjects as either responsive or non-responsive based on elevation in CSF selenium concentrations revealed that responsive group did not deteriorate in Mini-Mental Status Examination (MMSE) as non-responsive group (p = 0.03). Pooled analysis of all samples revealed that CSF selenium could predict change in MMSE performance (Spearman's rho = 0.403; p = 0.023). High-dose sodium selenate supplementation is well tolerated and can modulate CNS selenium concentration, although individual variation in selenium metabolism must be considered to optimize potential benefits in AD. The Vel002 study is listed on the Australian and New Zealand Clinical Trials Registry ( http://www.anzctr.org.au /), ID: ACTRN12611001200976.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N6954a2ca61cf49e68c3382d63569283d
58 Nbf138e620a0c4928a90af72212e8c088
59 sg:journal.1294839
60 schema:name Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer’s Disease
61 schema:pagination 192-202
62 schema:productId N17eada3fa78c467f90013ffc3b57b4f0
63 N29221f210374457daa37a466f5c2f088
64 N7632b6625af143f2b5789eec23d892b4
65 Neeb7272060cb4c63a8f41a1b9c7f7731
66 Nfa930a60d454420abed214ce261804b6
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106945903
68 https://doi.org/10.1007/s13311-018-0662-z
69 schema:sdDatePublished 2019-04-11T10:16
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N723b86c8fdd24547819fa40dd4e260f1
72 schema:url https://link.springer.com/10.1007%2Fs13311-018-0662-z
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N04738e13269c47fba7345669d805017b schema:name Caulfield Hospital, Alfred Health, Caulfield, Victoria, Australia
77 rdf:type schema:Organization
78 N08b9676633e24eb4a8850d92751a5a61 rdf:first sg:person.0711243243.82
79 rdf:rest Nce4e2ea34751401db3ccafbed864e5c4
80 N0b39df0dfa5a4dbe94e78b524d2b5e55 rdf:first sg:person.0676016754.26
81 rdf:rest N4f6aaf3b70844ca494c50bccaef295b6
82 N12d76f729adc4ddcbca8a436a92533ba rdf:first sg:person.01121233254.97
83 rdf:rest Ne4364f1940504596994ad1468426bfe4
84 N17ba5eff71824533bc4fe0aaef5fe2d1 rdf:first sg:person.012630724662.81
85 rdf:rest rdf:nil
86 N17eada3fa78c467f90013ffc3b57b4f0 schema:name dimensions_id
87 schema:value pub.1106945903
88 rdf:type schema:PropertyValue
89 N223ff507a40f4d8db9c5a29b0aad4fda schema:name Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia
90 rdf:type schema:Organization
91 N29221f210374457daa37a466f5c2f088 schema:name readcube_id
92 schema:value bbafff539f6d6fe0fae214782aa9067e05575b439b2392113cdb7003e2683275
93 rdf:type schema:PropertyValue
94 N4c932783f2344b4b8a15c93285b623cf schema:name Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia
95 rdf:type schema:Organization
96 N4f6aaf3b70844ca494c50bccaef295b6 rdf:first sg:person.0753745175.00
97 rdf:rest Nc80cf0a26ca14541b0616356c475b985
98 N6532a3e5c68940198e7e3c4e8cabb07d rdf:first sg:person.01167327663.01
99 rdf:rest N08b9676633e24eb4a8850d92751a5a61
100 N6954a2ca61cf49e68c3382d63569283d schema:volumeNumber 16
101 rdf:type schema:PublicationVolume
102 N723b86c8fdd24547819fa40dd4e260f1 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N743bd8d1837b47c1a90fd488c0277366 rdf:first sg:person.0613350466.96
105 rdf:rest Nb7c93f79826a44d281c41906b6ce3b63
106 N7632b6625af143f2b5789eec23d892b4 schema:name nlm_unique_id
107 schema:value 101290381
108 rdf:type schema:PropertyValue
109 N84baf33424fd48849a408cdc58df589c rdf:first sg:person.01063350511.50
110 rdf:rest Ndc5e315a72ef41d7a08b4e8581291a73
111 N870b6abd311843799b2303abccb2d997 rdf:first sg:person.01214124212.61
112 rdf:rest N8a5ea865187143a7b533c006b79dc656
113 N87d3342d628b417b9041e6f33fbfdacc rdf:first sg:person.01166724545.18
114 rdf:rest N0b39df0dfa5a4dbe94e78b524d2b5e55
115 N8a5ea865187143a7b533c006b79dc656 rdf:first sg:person.01115003444.87
116 rdf:rest N17ba5eff71824533bc4fe0aaef5fe2d1
117 N9071697a4af5424289d70dc426516a74 rdf:first sg:person.0672444704.96
118 rdf:rest N743bd8d1837b47c1a90fd488c0277366
119 Nab279e77df8f49369d72d63df488112d rdf:first sg:person.01236431544.30
120 rdf:rest N84baf33424fd48849a408cdc58df589c
121 Nab7d3e4f314041c892d2014eb3dd413b schema:name Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, 3052, Parkville, Victoria, Australia
122 rdf:type schema:Organization
123 Nb7c93f79826a44d281c41906b6ce3b63 rdf:first sg:person.01120750744.19
124 rdf:rest Nab279e77df8f49369d72d63df488112d
125 Nbf138e620a0c4928a90af72212e8c088 schema:issueNumber 1
126 rdf:type schema:PublicationIssue
127 Nbf6ec52892074170b1ad83b07797cd41 schema:name Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, 3052, Parkville, Victoria, Australia
128 rdf:type schema:Organization
129 Nc80cf0a26ca14541b0616356c475b985 rdf:first sg:person.01231620554.55
130 rdf:rest N6532a3e5c68940198e7e3c4e8cabb07d
131 Nce4e2ea34751401db3ccafbed864e5c4 rdf:first sg:person.0631042656.04
132 rdf:rest Neb9c6067cf134afda19d0eadd5b1785b
133 Nd6234821fba14a7bb8548f218aec2e30 schema:name Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, 3052, Parkville, Victoria, Australia
134 rdf:type schema:Organization
135 Ndc5e315a72ef41d7a08b4e8581291a73 rdf:first sg:person.01057416603.38
136 rdf:rest N870b6abd311843799b2303abccb2d997
137 Ne4364f1940504596994ad1468426bfe4 rdf:first sg:person.0616621550.24
138 rdf:rest N9071697a4af5424289d70dc426516a74
139 Neb9c6067cf134afda19d0eadd5b1785b rdf:first sg:person.0657640420.13
140 rdf:rest N12d76f729adc4ddcbca8a436a92533ba
141 Neeb7272060cb4c63a8f41a1b9c7f7731 schema:name doi
142 schema:value 10.1007/s13311-018-0662-z
143 rdf:type schema:PropertyValue
144 Nfa930a60d454420abed214ce261804b6 schema:name pubmed_id
145 schema:value 30215171
146 rdf:type schema:PropertyValue
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
151 schema:name Neurosciences
152 rdf:type schema:DefinedTerm
153 sg:grant.7874214 http://pending.schema.org/fundedItem sg:pub.10.1007/s13311-018-0662-z
154 rdf:type schema:MonetaryGrant
155 sg:grant.7874853 http://pending.schema.org/fundedItem sg:pub.10.1007/s13311-018-0662-z
156 rdf:type schema:MonetaryGrant
157 sg:grant.7875846 http://pending.schema.org/fundedItem sg:pub.10.1007/s13311-018-0662-z
158 rdf:type schema:MonetaryGrant
159 sg:grant.7877874 http://pending.schema.org/fundedItem sg:pub.10.1007/s13311-018-0662-z
160 rdf:type schema:MonetaryGrant
161 sg:grant.7879113 http://pending.schema.org/fundedItem sg:pub.10.1007/s13311-018-0662-z
162 rdf:type schema:MonetaryGrant
163 sg:journal.1294839 schema:issn 1878-7479
164 1933-7213
165 schema:name Neurotherapeutics
166 rdf:type schema:Periodical
167 sg:person.01057416603.38 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
168 schema:familyName Velakoulis
169 schema:givenName Dennis
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057416603.38
171 rdf:type schema:Person
172 sg:person.01063350511.50 schema:affiliation https://www.grid.ac/institutes/grid.416153.4
173 schema:familyName Hovens
174 schema:givenName Christopher M.
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063350511.50
176 rdf:type schema:Person
177 sg:person.01115003444.87 schema:affiliation Nab7d3e4f314041c892d2014eb3dd413b
178 schema:familyName Hare
179 schema:givenName Dominic J.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115003444.87
181 rdf:type schema:Person
182 sg:person.01120750744.19 schema:affiliation N04738e13269c47fba7345669d805017b
183 schema:familyName Macfarlane
184 schema:givenName Stephen
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120750744.19
186 rdf:type schema:Person
187 sg:person.01121233254.97 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
188 schema:familyName Hicks
189 schema:givenName Rodney J.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121233254.97
191 rdf:type schema:Person
192 sg:person.01166724545.18 schema:affiliation https://www.grid.ac/institutes/grid.1021.2
193 schema:familyName Cardoso
194 schema:givenName Barbara R.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166724545.18
196 rdf:type schema:Person
197 sg:person.01167327663.01 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
198 schema:familyName Genc
199 schema:givenName Sila
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167327663.01
201 rdf:type schema:Person
202 sg:person.01214124212.61 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
203 schema:familyName O’Brien
204 schema:givenName Terence J.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214124212.61
206 rdf:type schema:Person
207 sg:person.01231620554.55 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
208 schema:familyName Vivash
209 schema:givenName Lucy
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231620554.55
211 rdf:type schema:Person
212 sg:person.01236431544.30 schema:affiliation https://www.grid.ac/institutes/grid.416153.4
213 schema:familyName Corcoran
214 schema:givenName Niall M
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236431544.30
216 rdf:type schema:Person
217 sg:person.012630724662.81 schema:affiliation Nbf6ec52892074170b1ad83b07797cd41
218 schema:familyName Bush
219 schema:givenName Ashley I.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012630724662.81
221 rdf:type schema:Person
222 sg:person.0613350466.96 schema:affiliation https://www.grid.ac/institutes/grid.413105.2
223 schema:familyName Collins
224 schema:givenName Steven
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613350466.96
226 rdf:type schema:Person
227 sg:person.0616621550.24 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
228 schema:familyName Callahan
229 schema:givenName Jason
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616621550.24
231 rdf:type schema:Person
232 sg:person.0631042656.04 schema:affiliation N223ff507a40f4d8db9c5a29b0aad4fda
233 schema:familyName Desmond
234 schema:givenName Patricia
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631042656.04
236 rdf:type schema:Person
237 sg:person.0657640420.13 schema:affiliation N4c932783f2344b4b8a15c93285b623cf
238 schema:familyName Steward
239 schema:givenName Christopher
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657640420.13
241 rdf:type schema:Person
242 sg:person.0672444704.96 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
243 schema:familyName Brodtmann
244 schema:givenName Amy
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672444704.96
246 rdf:type schema:Person
247 sg:person.0676016754.26 schema:affiliation Nd6234821fba14a7bb8548f218aec2e30
248 schema:familyName Roberts
249 schema:givenName Blaine R.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676016754.26
251 rdf:type schema:Person
252 sg:person.0711243243.82 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
253 schema:familyName Saling
254 schema:givenName Michael M.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711243243.82
256 rdf:type schema:Person
257 sg:person.0753745175.00 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
258 schema:familyName Malpas
259 schema:givenName Charles B.
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753745175.00
261 rdf:type schema:Person
262 sg:pub.10.1007/s00204-014-1380-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031880818
263 https://doi.org/10.1007/s00204-014-1380-x
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s00216-012-6294-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1001998959
266 https://doi.org/10.1007/s00216-012-6294-y
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s00394-014-0829-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002036375
269 https://doi.org/10.1007/s00394-014-0829-2
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/mp.2016.196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008529431
272 https://doi.org/10.1038/mp.2016.196
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/nature05292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003167107
275 https://doi.org/10.1038/nature05292
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nchembio.1416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022089224
278 https://doi.org/10.1038/nchembio.1416
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nrd1330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003102113
281 https://doi.org/10.1038/nrd1330
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/sj.ejcn.1601800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039729593
284 https://doi.org/10.1038/sj.ejcn.1601800
285 rdf:type schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1080191144 schema:CreativeWork
287 https://doi.org/10.1001/archinternmed.2009.495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036765245
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1001/jamaneurol.2016.5778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084005989
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.brainresrev.2004.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021398364
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.cell.2012.03.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036616855
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.cell.2017.09.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092117016
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.expneurol.2017.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090662078
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.freeradbiomed.2009.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014678434
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.freeradbiomed.2018.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101039451
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.jalz.2013.05.1771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042416332
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.jocn.2010.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018501852
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.jtemb.2015.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028296840
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.jtemb.2017.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085137691
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.talanta.2006.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032552678
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.talanta.2013.02.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033127866
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.talanta.2016.02.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014548248
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.toxlet.2013.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027673951
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.trac.2017.09.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091892993
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s0140-6736(11)61452-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005650332
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1017/s0007114509992832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052057681
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1017/s0007114515003499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031569969
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1021/acschemneuro.7b00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085322114
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1021/ic800310j schema:sameAs https://app.dimensions.ai/details/publication/pub.1055582858
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1039/a904024b schema:sameAs https://app.dimensions.ai/details/publication/pub.1019241970
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1039/c3mt00227f schema:sameAs https://app.dimensions.ai/details/publication/pub.1038366038
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1039/c5mt00075k schema:sameAs https://app.dimensions.ai/details/publication/pub.1027608861
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1073/pnas.1009038107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002733944
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1089/ars.2006.1363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059230313
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1093/aje/kwk073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015522188
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1093/brain/awv053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014024756
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/j.1532-5415.2000.tb02603.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030207195
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1136/jnnp.2005.085332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044885685
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1212/wnl.34.7.939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024664401
350 rdf:type schema:CreativeWork
351 https://doi.org/10.3233/jad-160544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071127407
352 rdf:type schema:CreativeWork
353 https://doi.org/10.3233/jad-160622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083751086
354 rdf:type schema:CreativeWork
355 https://doi.org/10.3233/jad-2011-110414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078398850
356 rdf:type schema:CreativeWork
357 https://doi.org/10.3390/nu5041024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044618633
358 rdf:type schema:CreativeWork
359 https://doi.org/10.3791/53737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013734000
360 rdf:type schema:CreativeWork
361 https://doi.org/10.3945/ajcn.2010.29642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053347790
362 rdf:type schema:CreativeWork
363 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
364 schema:name Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia
365 Departments of Neuroscience and Neurology, The Central Clinical School and The Alfred Hospital, Monash University, Melbourne, Victoria, Australia
366 Developmental Imaging, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
367 Eastern Cognitive Disorders Clinic, Department of Neurology, Eastern Health, Monash University, Melbourne, Victoria, Australia
368 Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, 3052, Parkville, Victoria, Australia
369 Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia
370 rdf:type schema:Organization
371 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
372 schema:name Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
373 Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia
374 Developmental Imaging, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
375 Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia
376 rdf:type schema:Organization
377 https://www.grid.ac/institutes/grid.1021.2 schema:alternateName Deakin University
378 schema:name Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.1055.1 schema:alternateName Peter MacCallum Cancer Centre
381 schema:name Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
382 Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia
383 rdf:type schema:Organization
384 https://www.grid.ac/institutes/grid.413105.2 schema:alternateName St Vincent's Hospital
385 schema:name Department of Clinical Neurosciences and Neurological Research, St Vincent’s Hospital, Fitzroy, Victoria, Australia
386 Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia
387 rdf:type schema:Organization
388 https://www.grid.ac/institutes/grid.416153.4 schema:alternateName Royal Melbourne Hospital
389 schema:name Department of Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia
390 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...