Evaluation of 3K3A-Activated Protein C to Treat Neonatal Hypoxic Ischemic Brain Injury in the Spiny Mouse View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Stacey J. Ellery, Madeleine G. Goss, Nadine Brew, Hayley Dickinson, Nadia Hale, Domenic A. LaRosa, David W. Walker, Flora Y. Wong

ABSTRACT

Neonatal hypoxic ischemic encephalopathy (HIE) resulting from intrapartum asphyxia is a global problem that causes severe disabilities and up to 1 million deaths annually. A variant form of activated protein C, 3K3A-APC, has cytoprotective properties that attenuate brain injury in models of adult stroke. In this study, we compared the ability of 3K3A-APC and APC (wild-type (wt)) to attenuate neonatal brain injury, using the spiny mouse (Acomys cahirinus) model of intrapartum asphyxia. Pups were delivered at 38 days of gestation (term = 39 days), with an intrapartum hypoxic insult of 7.5 min (intrapartum asphyxia cohort), or immediate removal from the uterus (control cohort). After 1 h, pups received a subcutaneous injection of 3K3A-APC or wild-type APC (wtAPC) at 7 mg/kg, or vehicle (saline). At 24 h of age, pups were killed and brain tissue was collected for measurement of inflammation and cell death using RT-qPCR and histopathology. Intrapartum asphyxia increased weight loss, inflammation, and apoptosis/necrosis in the newborn brain. 3K3A-APC administration maintained body weight and ameliorated an asphyxia-induced increase of TGFβ1 messenger RNA expression in the cerebral cortex, immune cell aggregation in the corpus callosum, and cell death in the deep gray matter and hippocampus. In the cortex, 3K3A-APC appeared to exacerbate the immune response to the hypoxic ischemic insult. While wtAPC reduced cell death in the corpus callosum and hippocampus following intrapartum asphyxia, it increased markers of neuro-inflammation and cell death in control pups. These findings suggest 3K3A-APC administration may be a useful therapy to reduce cell death and neonatal brain injury associated with HIE. More... »

PAGES

231-243

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13311-018-0661-0

DOI

http://dx.doi.org/10.1007/s13311-018-0661-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107055541

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30225791


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia", 
            "Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellery", 
        "givenName": "Stacey J.", 
        "id": "sg:person.0740371751.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740371751.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hudson Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.452824.d", 
          "name": [
            "The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goss", 
        "givenName": "Madeleine G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hudson Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.452824.d", 
          "name": [
            "The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brew", 
        "givenName": "Nadine", 
        "id": "sg:person.0663077261.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663077261.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia", 
            "Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dickinson", 
        "givenName": "Hayley", 
        "id": "sg:person.01301434251.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301434251.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hudson Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.452824.d", 
          "name": [
            "The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hale", 
        "givenName": "Nadia", 
        "id": "sg:person.01216423357.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216423357.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brown University", 
          "id": "https://www.grid.ac/institutes/grid.40263.33", 
          "name": [
            "The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia", 
            "Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia", 
            "Women and Infants Hospital, Alpert Medical School, Brown University, Providence, RI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LaRosa", 
        "givenName": "Domenic A.", 
        "id": "sg:person.0624143351.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624143351.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RMIT University", 
          "id": "https://www.grid.ac/institutes/grid.1017.7", 
          "name": [
            "The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia", 
            "Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia", 
            "School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walker", 
        "givenName": "David W.", 
        "id": "sg:person.01201705422.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201705422.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia", 
            "Department of Paediatrics, Monash University, Clayton, Australia", 
            "Monash Newborn, Monash Medical Centre, Clayton, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "Flora Y.", 
        "id": "sg:person.0712352314.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712352314.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)60411-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000343221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0049-3848(16)30368-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003344610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0031-3955(05)70332-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005824662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-011-0284-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011703633", 
          "https://doi.org/10.1007/s00281-011-0284-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pr.2016.153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012764633", 
          "https://doi.org/10.1038/pr.2016.153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c100017200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013479445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2008.02.088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017876336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2009.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018122196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pr.2016.268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020453017", 
          "https://doi.org/10.1038/pr.2016.268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1253/circj.cj-13-0311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021317346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0031017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021623077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m500747200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024389796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pr.2012.174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024476550", 
          "https://doi.org/10.1038/pr.2012.174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/aps.2013.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025949827", 
          "https://doi.org/10.1038/aps.2013.89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.23647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026424004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1071699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029077785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000232562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031077122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000105475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034149498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.536680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034574032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.536680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034574032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-3806(94)00177-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035379855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2013.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036579640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneurol.2015.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036769742", 
          "https://doi.org/10.1038/nrneurol.2015.13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc3501.093799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037197698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2011.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037295439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jth.12424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038089906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0149840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038584810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0149840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038584810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0149840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038584810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2004.03.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039111324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2002-3-7-research0034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039751959", 
          "https://doi.org/10.1186/gb-2002-3-7-research0034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2011.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040616057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041597533", 
          "https://doi.org/10.1038/nm826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041597533", 
          "https://doi.org/10.1038/nm826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-3806(89)90055-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042412219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-3806(89)90055-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042412219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.23670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045179574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fncel.2013.00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047193368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cei.12453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049887408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.07-9574lsf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052334407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0009250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053380921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1160/th14-05-0448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063293756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138161212802430413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069168281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1381612819666131230131454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069169809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7196/sajch.574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073645897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077384294", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077455494", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2018-02-769026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104385336"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01", 
    "datePublishedReg": "2019-01-01", 
    "description": "Neonatal hypoxic ischemic encephalopathy (HIE) resulting from intrapartum asphyxia is a global problem that causes severe disabilities and up to 1 million deaths annually. A variant form of activated protein C, 3K3A-APC, has cytoprotective properties that attenuate brain injury in models of adult stroke. In this study, we compared the ability of 3K3A-APC and APC (wild-type (wt)) to attenuate neonatal brain injury, using the spiny mouse (Acomys cahirinus) model of intrapartum asphyxia. Pups were delivered at 38 days of gestation (term\u2009=\u200939\u00a0days), with an intrapartum hypoxic insult of 7.5\u00a0min (intrapartum asphyxia cohort), or immediate removal from the uterus (control cohort). After 1\u00a0h, pups received a subcutaneous injection of 3K3A-APC or wild-type APC (wtAPC) at 7\u00a0mg/kg, or vehicle (saline). At 24\u00a0h of age, pups were killed and brain tissue was collected for measurement of inflammation and cell death using RT-qPCR and histopathology. Intrapartum asphyxia increased weight loss, inflammation, and apoptosis/necrosis in the newborn brain. 3K3A-APC administration maintained body weight and ameliorated an asphyxia-induced increase of TGF\u03b21 messenger RNA expression in the cerebral cortex, immune cell aggregation in the corpus callosum, and cell death in the deep gray matter and hippocampus. In the cortex, 3K3A-APC appeared to exacerbate the immune response to the hypoxic ischemic insult. While wtAPC reduced cell death in the corpus callosum and hippocampus following intrapartum asphyxia, it increased markers of neuro-inflammation and cell death in control pups. These findings suggest 3K3A-APC administration may be a useful therapy to reduce cell death and neonatal brain injury associated with HIE.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13311-018-0661-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1294839", 
        "issn": [
          "1933-7213", 
          "1878-7479"
        ], 
        "name": "Neurotherapeutics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Evaluation of 3K3A-Activated Protein C to Treat Neonatal Hypoxic Ischemic Brain Injury in the Spiny Mouse", 
    "pagination": "231-243", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "23c0508becb273926181ad6d70f83adfa29b16bd0220b44d8ca3a202ad0a604f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30225791"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101290381"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13311-018-0661-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107055541"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13311-018-0661-0", 
      "https://app.dimensions.ai/details/publication/pub.1107055541"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54302_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs13311-018-0661-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13311-018-0661-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13311-018-0661-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13311-018-0661-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13311-018-0661-0'


 

This table displays all metadata directly associated to this object as RDF triples.

271 TRIPLES      21 PREDICATES      72 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13311-018-0661-0 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N94c73ab309574a9fa8dec58c141c61dc
4 schema:citation sg:pub.10.1007/s00281-011-0284-6
5 sg:pub.10.1038/aps.2013.89
6 sg:pub.10.1038/nm826
7 sg:pub.10.1038/nrneurol.2015.13
8 sg:pub.10.1038/pr.2012.174
9 sg:pub.10.1038/pr.2016.153
10 sg:pub.10.1038/pr.2016.268
11 sg:pub.10.1186/gb-2002-3-7-research0034
12 https://app.dimensions.ai/details/publication/pub.1077384294
13 https://app.dimensions.ai/details/publication/pub.1077455494
14 https://doi.org/10.1002/ana.23647
15 https://doi.org/10.1002/ana.23670
16 https://doi.org/10.1016/0165-3806(89)90055-2
17 https://doi.org/10.1016/0165-3806(94)00177-2
18 https://doi.org/10.1016/j.brainres.2008.02.088
19 https://doi.org/10.1016/j.dnarep.2004.03.027
20 https://doi.org/10.1016/j.neulet.2013.11.019
21 https://doi.org/10.1016/j.neuroscience.2011.05.012
22 https://doi.org/10.1016/j.tins.2009.08.002
23 https://doi.org/10.1016/j.tins.2011.01.005
24 https://doi.org/10.1016/s0031-3955(05)70332-1
25 https://doi.org/10.1016/s0049-3848(16)30368-1
26 https://doi.org/10.1016/s0140-6736(07)60411-5
27 https://doi.org/10.1074/jbc.c100017200
28 https://doi.org/10.1074/jbc.m500747200
29 https://doi.org/10.1096/fj.07-9574lsf
30 https://doi.org/10.1111/cei.12453
31 https://doi.org/10.1111/jth.12424
32 https://doi.org/10.1126/science.1071699
33 https://doi.org/10.1159/000105475
34 https://doi.org/10.1159/000232562
35 https://doi.org/10.1160/th14-05-0448
36 https://doi.org/10.1161/hc3501.093799
37 https://doi.org/10.1161/strokeaha.108.536680
38 https://doi.org/10.1182/blood-2018-02-769026
39 https://doi.org/10.1253/circj.cj-13-0311
40 https://doi.org/10.1371/journal.pone.0009250
41 https://doi.org/10.1371/journal.pone.0031017
42 https://doi.org/10.1371/journal.pone.0149840
43 https://doi.org/10.2174/138161212802430413
44 https://doi.org/10.2174/1381612819666131230131454
45 https://doi.org/10.3389/fncel.2013.00003
46 https://doi.org/10.7196/sajch.574
47 schema:datePublished 2019-01
48 schema:datePublishedReg 2019-01-01
49 schema:description Neonatal hypoxic ischemic encephalopathy (HIE) resulting from intrapartum asphyxia is a global problem that causes severe disabilities and up to 1 million deaths annually. A variant form of activated protein C, 3K3A-APC, has cytoprotective properties that attenuate brain injury in models of adult stroke. In this study, we compared the ability of 3K3A-APC and APC (wild-type (wt)) to attenuate neonatal brain injury, using the spiny mouse (Acomys cahirinus) model of intrapartum asphyxia. Pups were delivered at 38 days of gestation (term = 39 days), with an intrapartum hypoxic insult of 7.5 min (intrapartum asphyxia cohort), or immediate removal from the uterus (control cohort). After 1 h, pups received a subcutaneous injection of 3K3A-APC or wild-type APC (wtAPC) at 7 mg/kg, or vehicle (saline). At 24 h of age, pups were killed and brain tissue was collected for measurement of inflammation and cell death using RT-qPCR and histopathology. Intrapartum asphyxia increased weight loss, inflammation, and apoptosis/necrosis in the newborn brain. 3K3A-APC administration maintained body weight and ameliorated an asphyxia-induced increase of TGFβ1 messenger RNA expression in the cerebral cortex, immune cell aggregation in the corpus callosum, and cell death in the deep gray matter and hippocampus. In the cortex, 3K3A-APC appeared to exacerbate the immune response to the hypoxic ischemic insult. While wtAPC reduced cell death in the corpus callosum and hippocampus following intrapartum asphyxia, it increased markers of neuro-inflammation and cell death in control pups. These findings suggest 3K3A-APC administration may be a useful therapy to reduce cell death and neonatal brain injury associated with HIE.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf Nbf274bda138e4192993090c036843e1b
54 Nc7ff4090387940a49683faa9bca27f11
55 sg:journal.1294839
56 schema:name Evaluation of 3K3A-Activated Protein C to Treat Neonatal Hypoxic Ischemic Brain Injury in the Spiny Mouse
57 schema:pagination 231-243
58 schema:productId N7fbac37fa447471891ff23f5d4cd39ac
59 N871c9568bc5e4a0e972dc415d61147b9
60 Nb3befc8abf0b446db6cb24e170f9f34e
61 Nc1b13611128542908c35684efbe43b13
62 Nd1818b9756d84d5ba95121a6261b88b9
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107055541
64 https://doi.org/10.1007/s13311-018-0661-0
65 schema:sdDatePublished 2019-04-11T10:16
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N43b0c9bb45894cdab06a52375c639056
68 schema:url https://link.springer.com/10.1007%2Fs13311-018-0661-0
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N0a20c0fab14844d789062e3f0a520d48 rdf:first sg:person.01301434251.21
73 rdf:rest N28a124cef7304afba4cef02fa8e07a90
74 N0e8a034017694cb0afc3518829c50c8b rdf:first sg:person.01201705422.63
75 rdf:rest N26f28e8548dd43ee8ff0c71c41563ebe
76 N10249423515a4b6294f36bd3afc40dee rdf:first sg:person.0663077261.86
77 rdf:rest N0a20c0fab14844d789062e3f0a520d48
78 N26f28e8548dd43ee8ff0c71c41563ebe rdf:first sg:person.0712352314.08
79 rdf:rest rdf:nil
80 N28a124cef7304afba4cef02fa8e07a90 rdf:first sg:person.01216423357.47
81 rdf:rest Ncc9c9541b7354ef38da0b24ec3172b7f
82 N43b0c9bb45894cdab06a52375c639056 schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N44ebc59df2c843a09d3f07218cf0ac06 schema:affiliation https://www.grid.ac/institutes/grid.452824.d
85 schema:familyName Goss
86 schema:givenName Madeleine G.
87 rdf:type schema:Person
88 N7fbac37fa447471891ff23f5d4cd39ac schema:name nlm_unique_id
89 schema:value 101290381
90 rdf:type schema:PropertyValue
91 N871c9568bc5e4a0e972dc415d61147b9 schema:name dimensions_id
92 schema:value pub.1107055541
93 rdf:type schema:PropertyValue
94 N94c73ab309574a9fa8dec58c141c61dc rdf:first sg:person.0740371751.27
95 rdf:rest Ncfa2e83aea2d435bac21f2e8147bde61
96 Nb3befc8abf0b446db6cb24e170f9f34e schema:name doi
97 schema:value 10.1007/s13311-018-0661-0
98 rdf:type schema:PropertyValue
99 Nbf274bda138e4192993090c036843e1b schema:issueNumber 1
100 rdf:type schema:PublicationIssue
101 Nc1b13611128542908c35684efbe43b13 schema:name pubmed_id
102 schema:value 30225791
103 rdf:type schema:PropertyValue
104 Nc7ff4090387940a49683faa9bca27f11 schema:volumeNumber 16
105 rdf:type schema:PublicationVolume
106 Ncc9c9541b7354ef38da0b24ec3172b7f rdf:first sg:person.0624143351.10
107 rdf:rest N0e8a034017694cb0afc3518829c50c8b
108 Ncfa2e83aea2d435bac21f2e8147bde61 rdf:first N44ebc59df2c843a09d3f07218cf0ac06
109 rdf:rest N10249423515a4b6294f36bd3afc40dee
110 Nd1818b9756d84d5ba95121a6261b88b9 schema:name readcube_id
111 schema:value 23c0508becb273926181ad6d70f83adfa29b16bd0220b44d8ca3a202ad0a604f
112 rdf:type schema:PropertyValue
113 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
114 schema:name Medical and Health Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
117 schema:name Neurosciences
118 rdf:type schema:DefinedTerm
119 sg:journal.1294839 schema:issn 1878-7479
120 1933-7213
121 schema:name Neurotherapeutics
122 rdf:type schema:Periodical
123 sg:person.01201705422.63 schema:affiliation https://www.grid.ac/institutes/grid.1017.7
124 schema:familyName Walker
125 schema:givenName David W.
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201705422.63
127 rdf:type schema:Person
128 sg:person.01216423357.47 schema:affiliation https://www.grid.ac/institutes/grid.452824.d
129 schema:familyName Hale
130 schema:givenName Nadia
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216423357.47
132 rdf:type schema:Person
133 sg:person.01301434251.21 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
134 schema:familyName Dickinson
135 schema:givenName Hayley
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301434251.21
137 rdf:type schema:Person
138 sg:person.0624143351.10 schema:affiliation https://www.grid.ac/institutes/grid.40263.33
139 schema:familyName LaRosa
140 schema:givenName Domenic A.
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624143351.10
142 rdf:type schema:Person
143 sg:person.0663077261.86 schema:affiliation https://www.grid.ac/institutes/grid.452824.d
144 schema:familyName Brew
145 schema:givenName Nadine
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663077261.86
147 rdf:type schema:Person
148 sg:person.0712352314.08 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
149 schema:familyName Wong
150 schema:givenName Flora Y.
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712352314.08
152 rdf:type schema:Person
153 sg:person.0740371751.27 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
154 schema:familyName Ellery
155 schema:givenName Stacey J.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740371751.27
157 rdf:type schema:Person
158 sg:pub.10.1007/s00281-011-0284-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011703633
159 https://doi.org/10.1007/s00281-011-0284-6
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/aps.2013.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025949827
162 https://doi.org/10.1038/aps.2013.89
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/nm826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041597533
165 https://doi.org/10.1038/nm826
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/nrneurol.2015.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036769742
168 https://doi.org/10.1038/nrneurol.2015.13
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/pr.2012.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024476550
171 https://doi.org/10.1038/pr.2012.174
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/pr.2016.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012764633
174 https://doi.org/10.1038/pr.2016.153
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/pr.2016.268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020453017
177 https://doi.org/10.1038/pr.2016.268
178 rdf:type schema:CreativeWork
179 sg:pub.10.1186/gb-2002-3-7-research0034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039751959
180 https://doi.org/10.1186/gb-2002-3-7-research0034
181 rdf:type schema:CreativeWork
182 https://app.dimensions.ai/details/publication/pub.1077384294 schema:CreativeWork
183 https://app.dimensions.ai/details/publication/pub.1077455494 schema:CreativeWork
184 https://doi.org/10.1002/ana.23647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026424004
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1002/ana.23670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045179574
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0165-3806(89)90055-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042412219
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/0165-3806(94)00177-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035379855
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.brainres.2008.02.088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017876336
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.dnarep.2004.03.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039111324
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.neulet.2013.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036579640
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.neuroscience.2011.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037295439
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.tins.2009.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018122196
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.tins.2011.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040616057
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/s0031-3955(05)70332-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005824662
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s0049-3848(16)30368-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003344610
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/s0140-6736(07)60411-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000343221
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1074/jbc.c100017200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013479445
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1074/jbc.m500747200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024389796
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1096/fj.07-9574lsf schema:sameAs https://app.dimensions.ai/details/publication/pub.1052334407
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1111/cei.12453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049887408
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1111/jth.12424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038089906
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1126/science.1071699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029077785
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1159/000105475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034149498
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1159/000232562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031077122
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1160/th14-05-0448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063293756
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1161/hc3501.093799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037197698
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1161/strokeaha.108.536680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034574032
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1182/blood-2018-02-769026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104385336
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1253/circj.cj-13-0311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021317346
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1371/journal.pone.0009250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053380921
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1371/journal.pone.0031017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021623077
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1371/journal.pone.0149840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038584810
241 rdf:type schema:CreativeWork
242 https://doi.org/10.2174/138161212802430413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069168281
243 rdf:type schema:CreativeWork
244 https://doi.org/10.2174/1381612819666131230131454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069169809
245 rdf:type schema:CreativeWork
246 https://doi.org/10.3389/fncel.2013.00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047193368
247 rdf:type schema:CreativeWork
248 https://doi.org/10.7196/sajch.574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073645897
249 rdf:type schema:CreativeWork
250 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
251 schema:name Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia
252 The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.1017.7 schema:alternateName RMIT University
255 schema:name Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia
256 School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia
257 The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia
258 rdf:type schema:Organization
259 https://www.grid.ac/institutes/grid.40263.33 schema:alternateName Brown University
260 schema:name Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia
261 The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia
262 Women and Infants Hospital, Alpert Medical School, Brown University, Providence, RI, USA
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.416060.5 schema:alternateName Monash Medical Centre
265 schema:name Department of Paediatrics, Monash University, Clayton, Australia
266 Monash Newborn, Monash Medical Centre, Clayton, Melbourne, Australia
267 The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.452824.d schema:alternateName Hudson Institute of Medical Research
270 schema:name The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright St, 3168, Clayton, Melbourne, Australia
271 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...