Tumor Vaccines for Malignant Gliomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04

AUTHORS

Visish M. Srinivasan, Sherise D. Ferguson, Sungho Lee, Shiao-Pei Weathers, Brittany C. Parker Kerrigan, Amy B. Heimberger

ABSTRACT

Despite continued research efforts, glioblastoma multiforme (GBM) remains the deadliest brain tumor. Immunotherapy offers a novel way to treat this disease, the genetic signature of which is not completely elucidated. Additionally, these tumors are known to induce immunosuppression in the surrounding tumor microenvironment via an array of mechanisms, making effective treatment all the more difficult. The immunotherapeutic strategy of using tumor vaccines offers a way to harness the activity of the host immune system to potentially control tumor progression. GBM vaccines can react to a variety of tumor-specific antigens, which can be harvested from the patient's unique pathological condition using selected immunotherapy techniques. This article reviews the rationale behind and development of GBM vaccines, the relevant clinical trials, and the challenges involved in this treatment strategy. More... »

PAGES

345-357

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13311-017-0522-2

    DOI

    http://dx.doi.org/10.1007/s13311-017-0522-2

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28389997


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