Lipopolysaccharide and Curcumin Co-Stimulation Potentiates Olfactory Ensheathing Cell Phagocytosis Via Enhancing Their Activation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-14

AUTHORS

Ding-Jun Hao, Cuicui Liu, Lingling Zhang, Bo Chen, Qian Zhang, Rui Zhang, Jing An, Jingjing Zhao, Mingmei Wu, Yi Wang, Alfred Simental, Baorong He, Hao Yang

ABSTRACT

The gradual deterioration following central nervous system (CNS) injuries or neurodegenerative disorders is usually accompanied by infiltration of degenerated and apoptotic neural tissue debris. A rapid and efficient clearance of these deteriorated cell products is of pivotal importance in creating a permissive environment for regeneration of those damaged neurons. Our recent report revealed that the phagocytic activity of olfactory ensheathing cells (OECs) can make a substantial contribution to neuronal growth in such a hostile environment. However, little is known about how to further increase the ability of OECs in phagocytosing deleterious products. Here, we used an in vitro model of primary cells to investigate the effects of lipopolysaccharide (LPS) and curcumin (CCM) co-stimulation on phagocytic activity of OECs and the possible underlying mechanisms. Our results showed that co-stimulation using LPS and CCM can significantly enhance the activation of OECs, displaying a remarkable up-regulation in chemokine (C-X-C motif) ligand 1, chemokine (C-X-C motif) ligand 2, tumor necrosis factor-α, and Toll-like receptor 4, increased OEC proliferative activity, and improved phagocytic capacity compared with normal and LPS- or CCM-treated OECs. More importantly, this potentiated phagocytosis activity greatly facilitated neuronal growth under hostile culture conditions. Moreover, the up-regulation of transglutaminase-2 and phosphatidylserine receptor in OECs activated by LPS and CCM co-stimulation are likely responsible for mechanisms underlying the observed cellular events, because cystamine (a specific inhibitor of transglutaminase-2) and neutrophil elastase (a cleavage enzyme of phosphatidylserine receptor) can effectively abrogate all the positive effects of OECs, including phagocytic capacity and promotive effects on neuronal growth. This study provides an alternative strategy for the repair of traumatic nerve injury and neurologic diseases with the application of OECs in combination with LPS and CCM. More... »

PAGES

502-518

References to SciGraph publications

  • 2012-07-03. Phosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTEN in BMC CANCER
  • 2007-03. Olfactory ensheathing cell transplantation as a strategy for spinal cord repair—what can it achieve? in NATURE REVIEWS NEUROLOGY
  • 2002-06-16. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth in NATURE
  • 2008-03-07. Curcumin: From ancient medicine to current clinical trials in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2000-05. A receptor for phosphatidylserine-specific clearance of apoptotic cells in NATURE
  • 2008-05-07. The Promotive Effects of Thymosin β4 on Neuronal Survival and Neurite Outgrowth by Upregulating L1 Expression in NEUROCHEMICAL RESEARCH
  • 2000-01. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1 in NATURE
  • 2004-05. Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2015-01-07. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells in NATURE COMMUNICATIONS
  • 2009-01-07. De-differentiation Response of Cultured Astrocytes to Injury Induced by Scratch or Conditioned Culture Medium of Scratch-Insulted Astrocytes in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 2008-07-07. Olfactory ensheathing cells are attracted to, and can endocytose, bacteria in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2013-11-22. Phagocytic Removal of Neuronal Debris by Olfactory Ensheathing Cells Enhances Neuronal Survival and Neurite Outgrowth via p38MAPK Activity in MOLECULAR NEUROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13311-016-0485-8

    DOI

    http://dx.doi.org/10.1007/s13311-016-0485-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024405876

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27743319


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