Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04

AUTHORS

Dongliang Ma, Su-In Yoon, Chih-Hao Yang, Guillaume Marcy, Na Zhao, Wan-Ying Leong, Vinu Ganapathy, Ju Han, Antonius M. J. Van Dongen, Kuei-Sen Hsu, Guo-Li Ming, George J. Augustine, Eyleen L. K. Goh

ABSTRACT

Rett syndrome is a neurodevelopmental disorder that usually arises from mutations or deletions in methyl-CpG binding protein 2 (MeCP2), a transcriptional regulator that affects neuronal development and maturation without causing cell loss. Here, we show that silencing of MeCP2 decreased neurite arborization and synaptogenesis in cultured hippocampal neurons from rat fetal brains. These structural defects were associated with alterations in synaptic transmission and neural network activity. Similar retardation of dendritic growth was also observed in MeCP2-deficient newborn granule cells in the dentate gyrus of adult mouse brains in vivo, demonstrating direct and cell-autonomous effects on individual neurons. These defects, caused by MeCP2 deficiency, were reversed by treatment with the US Food and Drug Administration-approved drug, pentobarbital, in vitro and in vivo, possibly caused by modulation of γ-aminobutyric acid signaling. The results indicate that drugs modulating γ-aminobutyric acid signaling are potential therapeutics for Rett syndrome. More... »

PAGES

477-490

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13311-015-0343-0

DOI

http://dx.doi.org/10.1007/s13311-015-0343-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018732487

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25753729


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adjuvants, Anesthesia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Excitatory Postsynaptic Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hippocampus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methyl-CpG-Binding Protein 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Net", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pentobarbital", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Long-Evans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium Channel Blockers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synapsins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetrodotoxin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "gamma-Aminobutyric Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Duke NUS Graduate Medical School", 
          "id": "https://www.grid.ac/institutes/grid.428397.3", 
          "name": [
            "Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Dongliang", 
        "id": "sg:person.012463621432.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012463621432.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanyang Technological University", 
          "id": "https://www.grid.ac/institutes/grid.59025.3b", 
          "name": [
            "Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore", 
            "Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Su-In", 
        "id": "sg:person.0727373076.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727373076.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cheng Kung University", 
          "id": "https://www.grid.ac/institutes/grid.64523.36", 
          "name": [
            "Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Chih-Hao", 
        "id": "sg:person.0773325336.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773325336.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke NUS Graduate Medical School", 
          "id": "https://www.grid.ac/institutes/grid.428397.3", 
          "name": [
            "Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marcy", 
        "givenName": "Guillaume", 
        "id": "sg:person.01144770444.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144770444.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore", 
            "Department of Forensic Medicine, Key Laboratory of Health Ministry for Forensic Science, Xi\u2019an Jiaotong University School of Medicine, Xi\u2019an, Shaanxi, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Na", 
        "id": "sg:person.01170735153.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170735153.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke NUS Graduate Medical School", 
          "id": "https://www.grid.ac/institutes/grid.428397.3", 
          "name": [
            "Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leong", 
        "givenName": "Wan-Ying", 
        "id": "sg:person.0777565061.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777565061.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke NUS Graduate Medical School", 
          "id": "https://www.grid.ac/institutes/grid.428397.3", 
          "name": [
            "Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ganapathy", 
        "givenName": "Vinu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke NUS Graduate Medical School", 
          "id": "https://www.grid.ac/institutes/grid.428397.3", 
          "name": [
            "Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Ju", 
        "id": "sg:person.01176611025.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176611025.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Singapore", 
          "id": "https://www.grid.ac/institutes/grid.4280.e", 
          "name": [
            "Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore", 
            "Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Dongen", 
        "givenName": "Antonius M. J.", 
        "id": "sg:person.01275635041.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275635041.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cheng Kung University", 
          "id": "https://www.grid.ac/institutes/grid.64523.36", 
          "name": [
            "Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsu", 
        "givenName": "Kuei-Sen", 
        "id": "sg:person.01337172472.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337172472.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ming", 
        "givenName": "Guo-Li", 
        "id": "sg:person.011651157177.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011651157177.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Molecular and Cell Biology", 
          "id": "https://www.grid.ac/institutes/grid.418812.6", 
          "name": [
            "Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore", 
            "Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore", 
            "Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore", 
            "Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, Republic of Korea", 
            "Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Augustine", 
        "givenName": "George J.", 
        "id": "sg:person.01112775430.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112775430.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KK Women's and Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414963.d", 
          "name": [
            "Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore", 
            "Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore", 
            "Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore", 
            "KK Research Center, KK Women\u2019s and Children\u2019s Hospital, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goh", 
        "givenName": "Eyleen L. K.", 
        "id": "sg:person.015150274424.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015150274424.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0006-8993(97)00585-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000493343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5966-09.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000943805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002301472", 
          "https://doi.org/10.1038/13810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002301472", 
          "https://doi.org/10.1038/13810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2005.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002871583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2006.09.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003505118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004478617", 
          "https://doi.org/10.1038/nature04404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004478617", 
          "https://doi.org/10.1038/nature04404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004478617", 
          "https://doi.org/10.1038/nature04404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2009.04.062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008868353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0092169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009073436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2013.04.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012555265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0084806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013894618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00826.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015042817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.3434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015061522", 
          "https://doi.org/10.1038/nn.3434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2009.169805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016751015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2007.04.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018484447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019903916", 
          "https://doi.org/10.1038/nn.2275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.22409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024245307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.22409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024245307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0065572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025285435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0812394106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026104035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81887-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026306785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1206593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026622689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2009.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027345101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027385295", 
          "https://doi.org/10.1038/nature10214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-6606-1-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029354245", 
          "https://doi.org/10.1186/1756-6606-1-10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1138389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029745759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0042935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030207268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0507856102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031751494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0507856102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031751494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032194233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032194233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e31819d9ebc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032239194", 
          "https://doi.org/10.1203/pdr.0b013e31819d9ebc"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e31819d9ebc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032239194", 
          "https://doi.org/10.1203/pdr.0b013e31819d9ebc"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.109.002063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032272055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2005.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032431692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2005.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032431692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0031896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034447381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2008.09.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036700975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-010-0704-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038025680", 
          "https://doi.org/10.1007/s00109-010-0704-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.2001.00715.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040356405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0020733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041729790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410140412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042028396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2014.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043867240", 
          "https://doi.org/10.1038/npp.2014.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2009.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045328524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2623-05.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045681294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00337158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046296126", 
          "https://doi.org/10.1007/bf00337158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047116896", 
          "https://doi.org/10.1038/nature09582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047116896", 
          "https://doi.org/10.1038/nature09582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/epi.12025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048245002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0324-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048269615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00764.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048599768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1854-13.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049069014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.resp.2011.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050729388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(00)80265-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051107780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2008.12.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053044228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2006.02.062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053466693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00800.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053710175"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-04", 
    "datePublishedReg": "2015-04-01", 
    "description": "Rett syndrome is a neurodevelopmental disorder that usually arises from mutations or deletions in methyl-CpG binding protein 2 (MeCP2), a transcriptional regulator that affects neuronal development and maturation without causing cell loss. Here, we show that silencing of MeCP2 decreased neurite arborization and synaptogenesis in cultured hippocampal neurons from rat fetal brains. These structural defects were associated with alterations in synaptic transmission and neural network activity. Similar retardation of dendritic growth was also observed in MeCP2-deficient newborn granule cells in the dentate gyrus of adult mouse brains in vivo, demonstrating direct and cell-autonomous effects on individual neurons. These defects, caused by MeCP2 deficiency, were reversed by treatment with the US Food and Drug Administration-approved drug, pentobarbital, in vitro and in vivo, possibly caused by modulation of \u03b3-aminobutyric acid signaling. The results indicate that drugs modulating \u03b3-aminobutyric acid signaling are potential therapeutics for Rett syndrome.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s13311-015-0343-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2560982", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2528367", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1294839", 
        "issn": [
          "1933-7213", 
          "1878-7479"
        ], 
        "name": "Neurotherapeutics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital", 
    "pagination": "477-490", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "594108075af19c5660b34af46aa822bcbf71ba541a6585d5d26ff9e38c83691c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25753729"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101290381"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13311-015-0343-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018732487"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13311-015-0343-0", 
      "https://app.dimensions.ai/details/publication/pub.1018732487"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000521.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs13311-015-0343-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13311-015-0343-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13311-015-0343-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13311-015-0343-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13311-015-0343-0'


 

This table displays all metadata directly associated to this object as RDF triples.

428 TRIPLES      21 PREDICATES      99 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13311-015-0343-0 schema:about N13bbbf2d76484b6496d1af01fa4e23e4
2 N15d96921ce4e4902b3a418d1c961adf7
3 N2109e5c265d14fbab8203e2e49b2c16a
4 N27178216a76a4212b74e6db5380fe7e4
5 N3c3b8d5f108d46a78ed531f4b627229e
6 N3cce2dd6816549169f405feeeeaeeea9
7 N5fb1680481974de38c5ed301fcaa95b6
8 N70b4c513133b43cebdbeeadc84dc8a86
9 N899ccf34a36d4da3855a72231e15a09b
10 N8fe50fca05e348a2ad88c1d411b86df2
11 N983eebb454e1401692c303b5a42e8066
12 N9e8e41046b8043769468122aa44858d1
13 Na039531b15b040f1ba200e16c19bcb94
14 Na86f7b20632c47df9e1143dc4f695b4c
15 Nb543024d43fd475b924f60f30f33017d
16 Nc47f4bc7d6c447cdae5317520dbfa364
17 Ne450a8125abd498288866a957e78aafd
18 Ne4f76b3fc6244e6989c2e13ea20a4f37
19 Nfcb7d701a4804585b44140fcd9f3b589
20 Nff5b1a3e4fab47ae8414b89c421f15ac
21 anzsrc-for:06
22 anzsrc-for:0601
23 schema:author N583c3f7ba57749199fe66126ae5e22c1
24 schema:citation sg:pub.10.1007/bf00337158
25 sg:pub.10.1007/s00109-010-0704-4
26 sg:pub.10.1038/13810
27 sg:pub.10.1038/nature04404
28 sg:pub.10.1038/nature09582
29 sg:pub.10.1038/nature10214
30 sg:pub.10.1038/nn.2275
31 sg:pub.10.1038/nn.3434
32 sg:pub.10.1038/npp.2014.43
33 sg:pub.10.1186/1756-6606-1-10
34 sg:pub.10.1203/pdr.0b013e31819d9ebc
35 https://doi.org/10.1002/ana.410140412
36 https://doi.org/10.1002/jnr.22409
37 https://doi.org/10.1016/j.bpj.2008.09.037
38 https://doi.org/10.1016/j.cell.2010.10.016
39 https://doi.org/10.1016/j.cub.2006.02.062
40 https://doi.org/10.1016/j.expneurol.2009.12.007
41 https://doi.org/10.1016/j.nbd.2005.07.005
42 https://doi.org/10.1016/j.nbd.2007.04.005
43 https://doi.org/10.1016/j.nbd.2008.12.011
44 https://doi.org/10.1016/j.nbd.2009.05.001
45 https://doi.org/10.1016/j.nbd.2013.04.020
46 https://doi.org/10.1016/j.neuron.2006.09.037
47 https://doi.org/10.1016/j.neuroscience.2005.06.001
48 https://doi.org/10.1016/j.neuroscience.2009.04.062
49 https://doi.org/10.1016/j.resp.2011.02.002
50 https://doi.org/10.1016/s0006-8993(97)00585-4
51 https://doi.org/10.1016/s0092-8674(00)81887-5
52 https://doi.org/10.1016/s0896-6273(00)80265-2
53 https://doi.org/10.1073/pnas.0507856102
54 https://doi.org/10.1073/pnas.0812394106
55 https://doi.org/10.1111/epi.12025
56 https://doi.org/10.1111/j.1469-7793.2001.00715.x
57 https://doi.org/10.1113/jphysiol.2009.169805
58 https://doi.org/10.1124/pr.109.002063
59 https://doi.org/10.1126/science.1138389
60 https://doi.org/10.1126/science.1206593
61 https://doi.org/10.1152/jn.00764.2002
62 https://doi.org/10.1152/jn.00800.2010
63 https://doi.org/10.1152/jn.00826.2007
64 https://doi.org/10.1371/journal.pone.0020733
65 https://doi.org/10.1371/journal.pone.0031896
66 https://doi.org/10.1371/journal.pone.0042935
67 https://doi.org/10.1371/journal.pone.0065572
68 https://doi.org/10.1371/journal.pone.0084806
69 https://doi.org/10.1371/journal.pone.0092169
70 https://doi.org/10.1523/jneurosci.0324-09.2009
71 https://doi.org/10.1523/jneurosci.1854-13.2013
72 https://doi.org/10.1523/jneurosci.2623-05.2006
73 https://doi.org/10.1523/jneurosci.5966-09.2010
74 schema:datePublished 2015-04
75 schema:datePublishedReg 2015-04-01
76 schema:description Rett syndrome is a neurodevelopmental disorder that usually arises from mutations or deletions in methyl-CpG binding protein 2 (MeCP2), a transcriptional regulator that affects neuronal development and maturation without causing cell loss. Here, we show that silencing of MeCP2 decreased neurite arborization and synaptogenesis in cultured hippocampal neurons from rat fetal brains. These structural defects were associated with alterations in synaptic transmission and neural network activity. Similar retardation of dendritic growth was also observed in MeCP2-deficient newborn granule cells in the dentate gyrus of adult mouse brains in vivo, demonstrating direct and cell-autonomous effects on individual neurons. These defects, caused by MeCP2 deficiency, were reversed by treatment with the US Food and Drug Administration-approved drug, pentobarbital, in vitro and in vivo, possibly caused by modulation of γ-aminobutyric acid signaling. The results indicate that drugs modulating γ-aminobutyric acid signaling are potential therapeutics for Rett syndrome.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf Na371da94c2ea4e1a99ea7450a7919b93
81 Nc2e25bdf5aca4939b3d3b56f3eeaf4a8
82 sg:journal.1294839
83 schema:name Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital
84 schema:pagination 477-490
85 schema:productId N4ccac4f0fd3f45c0b94b80d4724c14a2
86 N884600b0ff184d35b6b9a843732981c9
87 Ne035831a6b0e4cba96c1fe4a936c2594
88 Nf3ac511e5b1e4a5ebd8e5c97289655fa
89 Nf77275d88eac439d9d993c7da3c962a4
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018732487
91 https://doi.org/10.1007/s13311-015-0343-0
92 schema:sdDatePublished 2019-04-10T22:34
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N624dc363d64f4d8ba18a22a8033ab58c
95 schema:url http://link.springer.com/10.1007%2Fs13311-015-0343-0
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N13bbbf2d76484b6496d1af01fa4e23e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Cells, Cultured
101 rdf:type schema:DefinedTerm
102 N15d96921ce4e4902b3a418d1c961adf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name gamma-Aminobutyric Acid
104 rdf:type schema:DefinedTerm
105 N2109e5c265d14fbab8203e2e49b2c16a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mice
107 rdf:type schema:DefinedTerm
108 N26276321d3864e9a92e96855effb6731 rdf:first sg:person.01176611025.63
109 rdf:rest Ne715468805134e6ca196dacf0ae7d34f
110 N27178216a76a4212b74e6db5380fe7e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Pentobarbital
112 rdf:type schema:DefinedTerm
113 N2eb66a5dac134e3c91b1039a99891312 rdf:first sg:person.0727373076.69
114 rdf:rest N6a1e35fec92c4876a28a047bc60efb02
115 N3c3b8d5f108d46a78ed531f4b627229e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Excitatory Postsynaptic Potentials
117 rdf:type schema:DefinedTerm
118 N3cce2dd6816549169f405feeeeaeeea9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Animals
120 rdf:type schema:DefinedTerm
121 N4ccac4f0fd3f45c0b94b80d4724c14a2 schema:name readcube_id
122 schema:value 594108075af19c5660b34af46aa822bcbf71ba541a6585d5d26ff9e38c83691c
123 rdf:type schema:PropertyValue
124 N583c3f7ba57749199fe66126ae5e22c1 rdf:first sg:person.012463621432.83
125 rdf:rest N2eb66a5dac134e3c91b1039a99891312
126 N5fb1680481974de38c5ed301fcaa95b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Nerve Net
128 rdf:type schema:DefinedTerm
129 N60f03c8f2dce47f2bfbe5803ceba58a5 rdf:first sg:person.01112775430.74
130 rdf:rest N9861da1773e3496fbe98138cc7006e6e
131 N624dc363d64f4d8ba18a22a8033ab58c schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N6a1e35fec92c4876a28a047bc60efb02 rdf:first sg:person.0773325336.98
134 rdf:rest Nce39c62702c8469fa85e4ba6b5c08bf0
135 N70b4c513133b43cebdbeeadc84dc8a86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Synapsins
137 rdf:type schema:DefinedTerm
138 N884600b0ff184d35b6b9a843732981c9 schema:name pubmed_id
139 schema:value 25753729
140 rdf:type schema:PropertyValue
141 N899ccf34a36d4da3855a72231e15a09b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Signal Transduction
143 rdf:type schema:DefinedTerm
144 N8fe50fca05e348a2ad88c1d411b86df2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Neurons
146 rdf:type schema:DefinedTerm
147 N982e3cadfc0647a2a0564c5eaabe9a2b rdf:first sg:person.01170735153.89
148 rdf:rest Nee6c704693294d2f8d7b9dd8dd8883df
149 N983eebb454e1401692c303b5a42e8066 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 N9861da1773e3496fbe98138cc7006e6e rdf:first sg:person.015150274424.70
153 rdf:rest rdf:nil
154 N9e8e41046b8043769468122aa44858d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Time Factors
156 rdf:type schema:DefinedTerm
157 Na039531b15b040f1ba200e16c19bcb94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Rats
159 rdf:type schema:DefinedTerm
160 Na371da94c2ea4e1a99ea7450a7919b93 schema:volumeNumber 12
161 rdf:type schema:PublicationVolume
162 Na86f7b20632c47df9e1143dc4f695b4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Sodium Channel Blockers
164 rdf:type schema:DefinedTerm
165 Nac6a5e3eaf3545858ed44978955af573 rdf:first sg:person.01337172472.30
166 rdf:rest Ndfa84b931bc44d8abdbe37d1818d3c60
167 Nb543024d43fd475b924f60f30f33017d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Hippocampus
169 rdf:type schema:DefinedTerm
170 Nc2e25bdf5aca4939b3d3b56f3eeaf4a8 schema:issueNumber 2
171 rdf:type schema:PublicationIssue
172 Nc47f4bc7d6c447cdae5317520dbfa364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Embryo, Mammalian
174 rdf:type schema:DefinedTerm
175 Nce39c62702c8469fa85e4ba6b5c08bf0 rdf:first sg:person.01144770444.51
176 rdf:rest N982e3cadfc0647a2a0564c5eaabe9a2b
177 Nd93265c41abe4114b8625d08356e6fbd schema:affiliation https://www.grid.ac/institutes/grid.428397.3
178 schema:familyName Ganapathy
179 schema:givenName Vinu
180 rdf:type schema:Person
181 Ndfa84b931bc44d8abdbe37d1818d3c60 rdf:first sg:person.011651157177.50
182 rdf:rest N60f03c8f2dce47f2bfbe5803ceba58a5
183 Ne035831a6b0e4cba96c1fe4a936c2594 schema:name nlm_unique_id
184 schema:value 101290381
185 rdf:type schema:PropertyValue
186 Ne450a8125abd498288866a957e78aafd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Adjuvants, Anesthesia
188 rdf:type schema:DefinedTerm
189 Ne4f76b3fc6244e6989c2e13ea20a4f37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Tetrodotoxin
191 rdf:type schema:DefinedTerm
192 Ne715468805134e6ca196dacf0ae7d34f rdf:first sg:person.01275635041.88
193 rdf:rest Nac6a5e3eaf3545858ed44978955af573
194 Nee6c704693294d2f8d7b9dd8dd8883df rdf:first sg:person.0777565061.03
195 rdf:rest Nf612d49bc4b54a14901f800e44c7e404
196 Nf3ac511e5b1e4a5ebd8e5c97289655fa schema:name doi
197 schema:value 10.1007/s13311-015-0343-0
198 rdf:type schema:PropertyValue
199 Nf612d49bc4b54a14901f800e44c7e404 rdf:first Nd93265c41abe4114b8625d08356e6fbd
200 rdf:rest N26276321d3864e9a92e96855effb6731
201 Nf77275d88eac439d9d993c7da3c962a4 schema:name dimensions_id
202 schema:value pub.1018732487
203 rdf:type schema:PropertyValue
204 Nfcb7d701a4804585b44140fcd9f3b589 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Rats, Long-Evans
206 rdf:type schema:DefinedTerm
207 Nff5b1a3e4fab47ae8414b89c421f15ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Methyl-CpG-Binding Protein 2
209 rdf:type schema:DefinedTerm
210 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
211 schema:name Biological Sciences
212 rdf:type schema:DefinedTerm
213 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
214 schema:name Biochemistry and Cell Biology
215 rdf:type schema:DefinedTerm
216 sg:grant.2528367 http://pending.schema.org/fundedItem sg:pub.10.1007/s13311-015-0343-0
217 rdf:type schema:MonetaryGrant
218 sg:grant.2560982 http://pending.schema.org/fundedItem sg:pub.10.1007/s13311-015-0343-0
219 rdf:type schema:MonetaryGrant
220 sg:journal.1294839 schema:issn 1878-7479
221 1933-7213
222 schema:name Neurotherapeutics
223 rdf:type schema:Periodical
224 sg:person.01112775430.74 schema:affiliation https://www.grid.ac/institutes/grid.418812.6
225 schema:familyName Augustine
226 schema:givenName George J.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112775430.74
228 rdf:type schema:Person
229 sg:person.01144770444.51 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
230 schema:familyName Marcy
231 schema:givenName Guillaume
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144770444.51
233 rdf:type schema:Person
234 sg:person.011651157177.50 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
235 schema:familyName Ming
236 schema:givenName Guo-Li
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011651157177.50
238 rdf:type schema:Person
239 sg:person.01170735153.89 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
240 schema:familyName Zhao
241 schema:givenName Na
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170735153.89
243 rdf:type schema:Person
244 sg:person.01176611025.63 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
245 schema:familyName Han
246 schema:givenName Ju
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176611025.63
248 rdf:type schema:Person
249 sg:person.012463621432.83 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
250 schema:familyName Ma
251 schema:givenName Dongliang
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012463621432.83
253 rdf:type schema:Person
254 sg:person.01275635041.88 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
255 schema:familyName Van Dongen
256 schema:givenName Antonius M. J.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275635041.88
258 rdf:type schema:Person
259 sg:person.01337172472.30 schema:affiliation https://www.grid.ac/institutes/grid.64523.36
260 schema:familyName Hsu
261 schema:givenName Kuei-Sen
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337172472.30
263 rdf:type schema:Person
264 sg:person.015150274424.70 schema:affiliation https://www.grid.ac/institutes/grid.414963.d
265 schema:familyName Goh
266 schema:givenName Eyleen L. K.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015150274424.70
268 rdf:type schema:Person
269 sg:person.0727373076.69 schema:affiliation https://www.grid.ac/institutes/grid.59025.3b
270 schema:familyName Yoon
271 schema:givenName Su-In
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727373076.69
273 rdf:type schema:Person
274 sg:person.0773325336.98 schema:affiliation https://www.grid.ac/institutes/grid.64523.36
275 schema:familyName Yang
276 schema:givenName Chih-Hao
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773325336.98
278 rdf:type schema:Person
279 sg:person.0777565061.03 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
280 schema:familyName Leong
281 schema:givenName Wan-Ying
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777565061.03
283 rdf:type schema:Person
284 sg:pub.10.1007/bf00337158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046296126
285 https://doi.org/10.1007/bf00337158
286 rdf:type schema:CreativeWork
287 sg:pub.10.1007/s00109-010-0704-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038025680
288 https://doi.org/10.1007/s00109-010-0704-4
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/13810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002301472
291 https://doi.org/10.1038/13810
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/nature04404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004478617
294 https://doi.org/10.1038/nature04404
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/nature09582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047116896
297 https://doi.org/10.1038/nature09582
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/nature10214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027385295
300 https://doi.org/10.1038/nature10214
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/nn.2275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019903916
303 https://doi.org/10.1038/nn.2275
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/nn.3434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015061522
306 https://doi.org/10.1038/nn.3434
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/npp.2014.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043867240
309 https://doi.org/10.1038/npp.2014.43
310 rdf:type schema:CreativeWork
311 sg:pub.10.1186/1756-6606-1-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029354245
312 https://doi.org/10.1186/1756-6606-1-10
313 rdf:type schema:CreativeWork
314 sg:pub.10.1203/pdr.0b013e31819d9ebc schema:sameAs https://app.dimensions.ai/details/publication/pub.1032239194
315 https://doi.org/10.1203/pdr.0b013e31819d9ebc
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1002/ana.410140412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042028396
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1002/jnr.22409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024245307
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.bpj.2008.09.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036700975
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.cell.2010.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032194233
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.cub.2006.02.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053466693
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.expneurol.2009.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045328524
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.nbd.2005.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032431692
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.nbd.2007.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018484447
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.nbd.2008.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053044228
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.nbd.2009.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027345101
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.nbd.2013.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012555265
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.neuron.2006.09.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003505118
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.neuroscience.2005.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002871583
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/j.neuroscience.2009.04.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008868353
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/j.resp.2011.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050729388
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/s0006-8993(97)00585-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000493343
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/s0092-8674(00)81887-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026306785
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/s0896-6273(00)80265-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051107780
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1073/pnas.0507856102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031751494
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1073/pnas.0812394106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026104035
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1111/epi.12025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048245002
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1111/j.1469-7793.2001.00715.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040356405
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1113/jphysiol.2009.169805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016751015
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1124/pr.109.002063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032272055
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1126/science.1138389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029745759
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1126/science.1206593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026622689
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1152/jn.00764.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048599768
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1152/jn.00800.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053710175
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1152/jn.00826.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015042817
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1371/journal.pone.0020733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041729790
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1371/journal.pone.0031896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034447381
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1371/journal.pone.0042935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030207268
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1371/journal.pone.0065572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025285435
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1371/journal.pone.0084806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013894618
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1371/journal.pone.0092169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009073436
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1523/jneurosci.0324-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048269615
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1523/jneurosci.1854-13.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049069014
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1523/jneurosci.2623-05.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045681294
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1523/jneurosci.5966-09.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000943805
394 rdf:type schema:CreativeWork
395 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
396 schema:name Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
397 rdf:type schema:Organization
398 https://www.grid.ac/institutes/grid.414963.d schema:alternateName KK Women's and Children's Hospital
399 schema:name Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
400 KK Research Center, KK Women’s and Children’s Hospital, Singapore, Singapore
401 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
402 Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore
403 rdf:type schema:Organization
404 https://www.grid.ac/institutes/grid.418812.6 schema:alternateName Institute of Molecular and Cell Biology
405 schema:name Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, Republic of Korea
406 Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
407 Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore, Singapore
408 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
409 Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore
410 rdf:type schema:Organization
411 https://www.grid.ac/institutes/grid.4280.e schema:alternateName National University of Singapore
412 schema:name Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
413 Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore
414 rdf:type schema:Organization
415 https://www.grid.ac/institutes/grid.428397.3 schema:alternateName Duke NUS Graduate Medical School
416 schema:name Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore
417 rdf:type schema:Organization
418 https://www.grid.ac/institutes/grid.43169.39 schema:alternateName Xi'an Jiaotong University
419 schema:name Department of Forensic Medicine, Key Laboratory of Health Ministry for Forensic Science, Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, People’s Republic of China
420 Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore
421 rdf:type schema:Organization
422 https://www.grid.ac/institutes/grid.59025.3b schema:alternateName Nanyang Technological University
423 schema:name Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
424 Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore
425 rdf:type schema:Organization
426 https://www.grid.ac/institutes/grid.64523.36 schema:alternateName National Cheng Kung University
427 schema:name Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
428 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...