The ALPPS procedure: hepatocellular carcinoma as a main indication. An Italian single-center experience View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Giovanni Vennarecci, Daniele Ferraro, Antonella Tudisco, Giovanni Battista Levi Sandri, Nicola Guglielmo, Giammauro Berardi, Isabella Sperduti, Giuseppe Maria Ettorre

ABSTRACT

The ALPPS is a technique that allows achieving hepatic resection by a rapid future liver remnant hypertrophy. The aim of this study was to report the experience of an Italian center with ALPPS in patients with liver tumors. A retrospective analysis of patients undergoing ALPPS between 2012 and 2017 was performed. Patients' characteristics and disease presentation, increase in future liver remnant (FLR) as well as intraoperative and postoperative short- and long-term outcomes were evaluated. A total of 24 patients underwent the ALPPS procedure: 17 procedures for hepatocarcinoma (HCC), 5 for colorectal liver metastases (CRLM), 1 for cholangiocarcinoma (CC) and 1 for Merkel Cell Carcinoma liver metastasis (MCCLM). Macrovascular invasion (MVI) was recorded in 10 (41.6%) patients: 8 (33.3%) patients with HCC had invasion of portal vein (5), middle hepatic vein (2) and inferior vena cava (1). One patient with CRLM had involvement of middle hepatic vein and one patient with CC had involvement of right portal vein and middle hepatic vein. A p-ALPPS in 14 cases (58.3%), 10 t-ALPPS (41.6%) and hanging maneuver in 19 patients (80%) were performed. Median postoperative stay was 26 days (range 16-68 days). 90-day mortality was 8.3% (two patients, one with CC and one with HCC), 90-day mortality for HCC was 5.8%. After stage 1, we counted 15 complications all of grade I; after stage 2 the number of complications was increased to 37:33 were of grade I and 4 were of grade IV. R0 resection was achieved in all patients with 100% oncology feasibility. After a median follow-up of 10 months (range 2-54), disease recurrence has been recorded in 6 patients with HCC and in 2 with CRLM. Eleven patients died, nine affected by HCC, one by CRLM, and one by CC. 2-years OS and disease-free survival (DFS) for the entire group were 47.3% and 47.5%, respectively. Concerning patients operated on for HCC, the 2-years OS and DFS were 38.5% and 60%, respectively. The ALPPS procedure is an interesting approach for large primary or secondary liver tumor with small FLR above all for large HCC associated with MVI, with acceptable OS and DFS. More... »

PAGES

1-9

References to SciGraph publications

  • 2015-09. Systematic Review and Meta-Analysis of Feasibility, Safety, and Efficacy of a Novel Procedure: Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy in ANNALS OF SURGICAL ONCOLOGY
  • 2014-06. ALPPS Offers a Better Chance of Complete Resection in Patients with Primarily Unresectable Liver Tumors Compared with Conventional-Staged Hepatectomies: Results of a Multicenter Analysis in WORLD JOURNAL OF SURGERY
  • 2013-04. Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS): Tips and Tricks in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2016-04. Should ALPPS be Used for Liver Resection in Intermediate-Stage HCC? in ANNALS OF SURGICAL ONCOLOGY
  • 2014-06. ALPPS for Patients with Colorectal Liver Metastases: Effective Liver Hypertrophy, but Early Tumor Recurrence in WORLD JOURNAL OF SURGERY
  • 2017-09. Contribution of hepatobiliary scintigraphy in assessing ALPPS most suited timing in UPDATES IN SURGERY
  • 2013-01. Using ALPPS to Induce Rapid Liver Hypertrophy in a Patient with Hepatic Fibrosis and Portal Vein Thrombosis in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2017-03. A literature review of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): so far, so good in UPDATES IN SURGERY
  • 2014-06. The ALPPS Procedure: A Surgical Option for Hepatocellular Carcinoma with Major Vascular Invasion in WORLD JOURNAL OF SURGERY
  • 2015-06. Strategies to Increase the Resectability of Patients with Colorectal Liver Metastases: A Multi-center Case-Match Analysis of ALPPS and Conventional Two-Stage Hepatectomy in ANNALS OF SURGICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s13304-018-0596-3

    DOI

    http://dx.doi.org/10.1007/s13304-018-0596-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107221074

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30255436


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Ospedale San Camillo", 
              "id": "https://www.grid.ac/institutes/grid.416308.8", 
              "name": [
                "Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Circ.ne Gianicolense 87, 00151, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vennarecci", 
            "givenName": "Giovanni", 
            "id": "sg:person.0611306744.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611306744.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ospedale San Camillo", 
              "id": "https://www.grid.ac/institutes/grid.416308.8", 
              "name": [
                "Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Circ.ne Gianicolense 87, 00151, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferraro", 
            "givenName": "Daniele", 
            "id": "sg:person.012066426321.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012066426321.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ospedale San Camillo", 
              "id": "https://www.grid.ac/institutes/grid.416308.8", 
              "name": [
                "Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Circ.ne Gianicolense 87, 00151, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tudisco", 
            "givenName": "Antonella", 
            "id": "sg:person.01042474563.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042474563.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ospedale San Camillo", 
              "id": "https://www.grid.ac/institutes/grid.416308.8", 
              "name": [
                "Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Circ.ne Gianicolense 87, 00151, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Levi Sandri", 
            "givenName": "Giovanni Battista", 
            "id": "sg:person.012321242741.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012321242741.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ospedale San Camillo", 
              "id": "https://www.grid.ac/institutes/grid.416308.8", 
              "name": [
                "Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Circ.ne Gianicolense 87, 00151, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guglielmo", 
            "givenName": "Nicola", 
            "id": "sg:person.01343325771.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343325771.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ospedale San Camillo", 
              "id": "https://www.grid.ac/institutes/grid.416308.8", 
              "name": [
                "Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Circ.ne Gianicolense 87, 00151, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Berardi", 
            "givenName": "Giammauro", 
            "id": "sg:person.0747272364.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747272364.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituti Fisioterapici Ospitalieri", 
              "id": "https://www.grid.ac/institutes/grid.417520.5", 
              "name": [
                "Biostatistical Unit, Regina Elena National Cancer Institute, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sperduti", 
            "givenName": "Isabella", 
            "id": "sg:person.01323700675.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323700675.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ospedale San Camillo", 
              "id": "https://www.grid.ac/institutes/grid.416308.8", 
              "name": [
                "Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Circ.ne Gianicolense 87, 00151, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ettorre", 
            "givenName": "Giuseppe Maria", 
            "id": "sg:person.01153514070.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153514070.86"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1097/sla.0000000000001087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003288281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000001087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003288281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-015-5007-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004467227", 
              "https://doi.org/10.1245/s10434-015-5007-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhep.2016.05.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004650844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhep.2016.05.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004650844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13304-016-0401-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008564505", 
              "https://doi.org/10.1007/s13304-016-0401-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13304-016-0401-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008564505", 
              "https://doi.org/10.1007/s13304-016-0401-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000048447.16651.7b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008677963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000048447.16651.7b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008677963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/hpb.12386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013526410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-012-2029-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014548529", 
              "https://doi.org/10.1007/s11605-012-2029-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.hpb.2016.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017676777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejso.2015.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019154592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijsu.2016.04.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021573241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31824856f5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022177341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31824856f5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022177341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijsu.2014.11.054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023197526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-012-2092-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029542393", 
              "https://doi.org/10.1007/s11605-012-2092-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000001272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029654558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000001272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029654558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjsurg.2008.04.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030780261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-013-2401-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035433988", 
              "https://doi.org/10.1007/s00268-013-2401-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1499-3872(15)60414-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036631073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijscr.2016.07.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039641432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.6756", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043375162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-013-2296-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046045667", 
              "https://doi.org/10.1007/s00268-013-2296-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-014-2513-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046702298", 
              "https://doi.org/10.1007/s00268-014-2513-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jamcollsurg.2013.03.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046823217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000001007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047210883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000001007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047210883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31815f6e5b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048452135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31815f6e5b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048452135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-014-4213-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049561328", 
              "https://doi.org/10.1245/s10434-014-4213-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-014-4291-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049874261", 
              "https://doi.org/10.1245/s10434-014-4291-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000065265.16728.c0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049992611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000065265.16728.c0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049992611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhep.2011.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051138497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.29086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074239526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1553350617697187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084247553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1553350617697187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084247553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/liv.13491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085994893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13304-017-0481-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091117074", 
              "https://doi.org/10.1007/s13304-017-0481-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13304-017-0481-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091117074", 
              "https://doi.org/10.1007/s13304-017-0481-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.21299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091987381"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03", 
        "datePublishedReg": "2019-03-01", 
        "description": "The ALPPS is a technique that allows achieving hepatic resection by a rapid future liver remnant hypertrophy. The aim of this study was to report the experience of an Italian center with ALPPS in patients with liver tumors. A retrospective analysis of patients undergoing ALPPS between 2012 and 2017 was performed. Patients' characteristics and disease presentation, increase in future liver remnant (FLR) as well as intraoperative and postoperative short- and long-term outcomes were evaluated. A total of 24 patients underwent the ALPPS procedure: 17 procedures for hepatocarcinoma (HCC), 5 for colorectal liver metastases (CRLM), 1 for cholangiocarcinoma (CC) and 1 for Merkel Cell Carcinoma liver metastasis (MCCLM). Macrovascular invasion (MVI) was recorded in 10 (41.6%) patients: 8 (33.3%) patients with HCC had invasion of portal vein (5), middle hepatic vein (2) and inferior vena cava (1). One patient with CRLM had involvement of middle hepatic vein and one patient with CC had involvement of right portal vein and middle hepatic vein. A p-ALPPS in 14 cases (58.3%), 10 t-ALPPS (41.6%) and hanging maneuver in 19 patients (80%) were performed. Median postoperative stay was 26\u00a0days (range 16-68\u00a0days). 90-day mortality was 8.3% (two patients, one with CC and one with HCC), 90-day mortality for HCC was 5.8%. After stage 1, we counted 15 complications all of grade I; after stage 2 the number of complications was increased to 37:33 were of grade I and 4 were of grade IV. R0 resection was achieved in all patients with 100% oncology feasibility. After a median follow-up of 10\u00a0months (range 2-54), disease recurrence has been recorded in 6 patients with HCC and in 2 with CRLM. Eleven patients died, nine affected by HCC, one by CRLM, and one by CC. 2-years OS and disease-free survival (DFS) for the entire group were 47.3% and 47.5%, respectively. Concerning patients operated on for HCC, the 2-years OS and DFS were 38.5% and 60%, respectively. The ALPPS procedure is an interesting approach for large primary or secondary liver tumor with small FLR above all for large HCC associated with MVI, with acceptable OS and DFS.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s13304-018-0596-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1345415", 
            "issn": [
              "2038-131X", 
              "2038-3312"
            ], 
            "name": "Updates in Surgery", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "71"
          }
        ], 
        "name": "The ALPPS procedure: hepatocellular carcinoma as a main indication. An Italian single-center experience", 
        "pagination": "1-9", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s13304-018-0596-3"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0c6981506ba34b512d7271d43eb39dbbbb5e7aae94767947bb80b12a234cf8fb"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1107221074"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101539818"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30255436"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s13304-018-0596-3", 
          "https://app.dimensions.ai/details/publication/pub.1107221074"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T08:51", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119732_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs13304-018-0596-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13304-018-0596-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13304-018-0596-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13304-018-0596-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13304-018-0596-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    230 TRIPLES      21 PREDICATES      62 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s13304-018-0596-3 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author N2a6843ba67e94cc98b5ffae7e5b7f944
    4 schema:citation sg:pub.10.1007/s00268-013-2296-y
    5 sg:pub.10.1007/s00268-013-2401-2
    6 sg:pub.10.1007/s00268-014-2513-3
    7 sg:pub.10.1007/s11605-012-2029-9
    8 sg:pub.10.1007/s11605-012-2092-2
    9 sg:pub.10.1007/s13304-016-0401-0
    10 sg:pub.10.1007/s13304-017-0481-5
    11 sg:pub.10.1245/s10434-014-4213-5
    12 sg:pub.10.1245/s10434-014-4291-4
    13 sg:pub.10.1245/s10434-015-5007-0
    14 https://doi.org/10.1002/bjs.6756
    15 https://doi.org/10.1002/hep.29086
    16 https://doi.org/10.1016/j.amjsurg.2008.04.022
    17 https://doi.org/10.1016/j.ejso.2015.01.004
    18 https://doi.org/10.1016/j.hpb.2016.02.003
    19 https://doi.org/10.1016/j.ijscr.2016.07.039
    20 https://doi.org/10.1016/j.ijsu.2014.11.054
    21 https://doi.org/10.1016/j.ijsu.2016.04.031
    22 https://doi.org/10.1016/j.jamcollsurg.2013.03.004
    23 https://doi.org/10.1016/j.jhep.2011.12.001
    24 https://doi.org/10.1016/j.jhep.2016.05.044
    25 https://doi.org/10.1016/s1499-3872(15)60414-3
    26 https://doi.org/10.1097/01.sla.0000048447.16651.7b
    27 https://doi.org/10.1097/01.sla.0000065265.16728.c0
    28 https://doi.org/10.1097/sla.0000000000001007
    29 https://doi.org/10.1097/sla.0000000000001087
    30 https://doi.org/10.1097/sla.0000000000001272
    31 https://doi.org/10.1097/sla.0b013e31815f6e5b
    32 https://doi.org/10.1097/sla.0b013e31824856f5
    33 https://doi.org/10.1111/hpb.12386
    34 https://doi.org/10.1111/liv.13491
    35 https://doi.org/10.1177/1553350617697187
    36 https://doi.org/10.18632/oncotarget.21299
    37 schema:datePublished 2019-03
    38 schema:datePublishedReg 2019-03-01
    39 schema:description The ALPPS is a technique that allows achieving hepatic resection by a rapid future liver remnant hypertrophy. The aim of this study was to report the experience of an Italian center with ALPPS in patients with liver tumors. A retrospective analysis of patients undergoing ALPPS between 2012 and 2017 was performed. Patients' characteristics and disease presentation, increase in future liver remnant (FLR) as well as intraoperative and postoperative short- and long-term outcomes were evaluated. A total of 24 patients underwent the ALPPS procedure: 17 procedures for hepatocarcinoma (HCC), 5 for colorectal liver metastases (CRLM), 1 for cholangiocarcinoma (CC) and 1 for Merkel Cell Carcinoma liver metastasis (MCCLM). Macrovascular invasion (MVI) was recorded in 10 (41.6%) patients: 8 (33.3%) patients with HCC had invasion of portal vein (5), middle hepatic vein (2) and inferior vena cava (1). One patient with CRLM had involvement of middle hepatic vein and one patient with CC had involvement of right portal vein and middle hepatic vein. A p-ALPPS in 14 cases (58.3%), 10 t-ALPPS (41.6%) and hanging maneuver in 19 patients (80%) were performed. Median postoperative stay was 26 days (range 16-68 days). 90-day mortality was 8.3% (two patients, one with CC and one with HCC), 90-day mortality for HCC was 5.8%. After stage 1, we counted 15 complications all of grade I; after stage 2 the number of complications was increased to 37:33 were of grade I and 4 were of grade IV. R0 resection was achieved in all patients with 100% oncology feasibility. After a median follow-up of 10 months (range 2-54), disease recurrence has been recorded in 6 patients with HCC and in 2 with CRLM. Eleven patients died, nine affected by HCC, one by CRLM, and one by CC. 2-years OS and disease-free survival (DFS) for the entire group were 47.3% and 47.5%, respectively. Concerning patients operated on for HCC, the 2-years OS and DFS were 38.5% and 60%, respectively. The ALPPS procedure is an interesting approach for large primary or secondary liver tumor with small FLR above all for large HCC associated with MVI, with acceptable OS and DFS.
    40 schema:genre research_article
    41 schema:inLanguage en
    42 schema:isAccessibleForFree false
    43 schema:isPartOf N0f9c064b15df43828736da71729a7198
    44 N4c3f1f935a464cd3814d9bcf8a8f5873
    45 sg:journal.1345415
    46 schema:name The ALPPS procedure: hepatocellular carcinoma as a main indication. An Italian single-center experience
    47 schema:pagination 1-9
    48 schema:productId N0ee57f5c033342d982a207433b307135
    49 N39b4570f5a544e3580d7b8b61728bf65
    50 N4ecaa59750a74e3c95fe125f1d50ea81
    51 N81b14098c48447809b74a19b694124db
    52 Nc33592a12ebe46de8cd0f31f81e7b33c
    53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107221074
    54 https://doi.org/10.1007/s13304-018-0596-3
    55 schema:sdDatePublished 2019-04-15T08:51
    56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    57 schema:sdPublisher N126a1850630b4bd99189455c383d8e87
    58 schema:url https://link.springer.com/10.1007%2Fs13304-018-0596-3
    59 sgo:license sg:explorer/license/
    60 sgo:sdDataset articles
    61 rdf:type schema:ScholarlyArticle
    62 N0ee57f5c033342d982a207433b307135 schema:name nlm_unique_id
    63 schema:value 101539818
    64 rdf:type schema:PropertyValue
    65 N0f9c064b15df43828736da71729a7198 schema:volumeNumber 71
    66 rdf:type schema:PublicationVolume
    67 N126a1850630b4bd99189455c383d8e87 schema:name Springer Nature - SN SciGraph project
    68 rdf:type schema:Organization
    69 N2a6843ba67e94cc98b5ffae7e5b7f944 rdf:first sg:person.0611306744.39
    70 rdf:rest Nf737fe27a5e44dd0a5bc14b2306666b7
    71 N39b4570f5a544e3580d7b8b61728bf65 schema:name dimensions_id
    72 schema:value pub.1107221074
    73 rdf:type schema:PropertyValue
    74 N4c3f1f935a464cd3814d9bcf8a8f5873 schema:issueNumber 1
    75 rdf:type schema:PublicationIssue
    76 N4ecaa59750a74e3c95fe125f1d50ea81 schema:name readcube_id
    77 schema:value 0c6981506ba34b512d7271d43eb39dbbbb5e7aae94767947bb80b12a234cf8fb
    78 rdf:type schema:PropertyValue
    79 N5c0cd86a398c42a297f37211ba7f2beb rdf:first sg:person.01153514070.86
    80 rdf:rest rdf:nil
    81 N81b14098c48447809b74a19b694124db schema:name doi
    82 schema:value 10.1007/s13304-018-0596-3
    83 rdf:type schema:PropertyValue
    84 Nc33592a12ebe46de8cd0f31f81e7b33c schema:name pubmed_id
    85 schema:value 30255436
    86 rdf:type schema:PropertyValue
    87 Nc3729e53b88e4c2faf2314310f0f6d7c rdf:first sg:person.01343325771.54
    88 rdf:rest Ne273317980504d86a4c5e545e2f0384c
    89 Nd6fd4a84906746ec94e9a3e101d5c614 rdf:first sg:person.012321242741.24
    90 rdf:rest Nc3729e53b88e4c2faf2314310f0f6d7c
    91 Ne273317980504d86a4c5e545e2f0384c rdf:first sg:person.0747272364.59
    92 rdf:rest Ne9a41a98fff44108b1bd23e9d00734a7
    93 Ne9a41a98fff44108b1bd23e9d00734a7 rdf:first sg:person.01323700675.54
    94 rdf:rest N5c0cd86a398c42a297f37211ba7f2beb
    95 Nf737fe27a5e44dd0a5bc14b2306666b7 rdf:first sg:person.012066426321.71
    96 rdf:rest Nfb8119f59aba4b9196e68eb4d2e36b10
    97 Nfb8119f59aba4b9196e68eb4d2e36b10 rdf:first sg:person.01042474563.38
    98 rdf:rest Nd6fd4a84906746ec94e9a3e101d5c614
    99 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    100 schema:name Medical and Health Sciences
    101 rdf:type schema:DefinedTerm
    102 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    103 schema:name Clinical Sciences
    104 rdf:type schema:DefinedTerm
    105 sg:journal.1345415 schema:issn 2038-131X
    106 2038-3312
    107 schema:name Updates in Surgery
    108 rdf:type schema:Periodical
    109 sg:person.01042474563.38 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
    110 schema:familyName Tudisco
    111 schema:givenName Antonella
    112 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042474563.38
    113 rdf:type schema:Person
    114 sg:person.01153514070.86 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
    115 schema:familyName Ettorre
    116 schema:givenName Giuseppe Maria
    117 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153514070.86
    118 rdf:type schema:Person
    119 sg:person.012066426321.71 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
    120 schema:familyName Ferraro
    121 schema:givenName Daniele
    122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012066426321.71
    123 rdf:type schema:Person
    124 sg:person.012321242741.24 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
    125 schema:familyName Levi Sandri
    126 schema:givenName Giovanni Battista
    127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012321242741.24
    128 rdf:type schema:Person
    129 sg:person.01323700675.54 schema:affiliation https://www.grid.ac/institutes/grid.417520.5
    130 schema:familyName Sperduti
    131 schema:givenName Isabella
    132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323700675.54
    133 rdf:type schema:Person
    134 sg:person.01343325771.54 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
    135 schema:familyName Guglielmo
    136 schema:givenName Nicola
    137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343325771.54
    138 rdf:type schema:Person
    139 sg:person.0611306744.39 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
    140 schema:familyName Vennarecci
    141 schema:givenName Giovanni
    142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611306744.39
    143 rdf:type schema:Person
    144 sg:person.0747272364.59 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
    145 schema:familyName Berardi
    146 schema:givenName Giammauro
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747272364.59
    148 rdf:type schema:Person
    149 sg:pub.10.1007/s00268-013-2296-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1046045667
    150 https://doi.org/10.1007/s00268-013-2296-y
    151 rdf:type schema:CreativeWork
    152 sg:pub.10.1007/s00268-013-2401-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035433988
    153 https://doi.org/10.1007/s00268-013-2401-2
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1007/s00268-014-2513-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046702298
    156 https://doi.org/10.1007/s00268-014-2513-3
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1007/s11605-012-2029-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014548529
    159 https://doi.org/10.1007/s11605-012-2029-9
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1007/s11605-012-2092-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029542393
    162 https://doi.org/10.1007/s11605-012-2092-2
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1007/s13304-016-0401-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008564505
    165 https://doi.org/10.1007/s13304-016-0401-0
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1007/s13304-017-0481-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091117074
    168 https://doi.org/10.1007/s13304-017-0481-5
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1245/s10434-014-4213-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049561328
    171 https://doi.org/10.1245/s10434-014-4213-5
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1245/s10434-014-4291-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049874261
    174 https://doi.org/10.1245/s10434-014-4291-4
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1245/s10434-015-5007-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004467227
    177 https://doi.org/10.1245/s10434-015-5007-0
    178 rdf:type schema:CreativeWork
    179 https://doi.org/10.1002/bjs.6756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043375162
    180 rdf:type schema:CreativeWork
    181 https://doi.org/10.1002/hep.29086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074239526
    182 rdf:type schema:CreativeWork
    183 https://doi.org/10.1016/j.amjsurg.2008.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030780261
    184 rdf:type schema:CreativeWork
    185 https://doi.org/10.1016/j.ejso.2015.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019154592
    186 rdf:type schema:CreativeWork
    187 https://doi.org/10.1016/j.hpb.2016.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017676777
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1016/j.ijscr.2016.07.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039641432
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1016/j.ijsu.2014.11.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023197526
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/j.ijsu.2016.04.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021573241
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/j.jamcollsurg.2013.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046823217
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/j.jhep.2011.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051138497
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/j.jhep.2016.05.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004650844
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/s1499-3872(15)60414-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036631073
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1097/01.sla.0000048447.16651.7b schema:sameAs https://app.dimensions.ai/details/publication/pub.1008677963
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1097/01.sla.0000065265.16728.c0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049992611
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1097/sla.0000000000001007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047210883
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1097/sla.0000000000001087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003288281
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1097/sla.0000000000001272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029654558
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1097/sla.0b013e31815f6e5b schema:sameAs https://app.dimensions.ai/details/publication/pub.1048452135
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1097/sla.0b013e31824856f5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022177341
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1111/hpb.12386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013526410
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1111/liv.13491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085994893
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1177/1553350617697187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084247553
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.18632/oncotarget.21299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091987381
    224 rdf:type schema:CreativeWork
    225 https://www.grid.ac/institutes/grid.416308.8 schema:alternateName Ospedale San Camillo
    226 schema:name Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Circ.ne Gianicolense 87, 00151, Rome, Italy
    227 rdf:type schema:Organization
    228 https://www.grid.ac/institutes/grid.417520.5 schema:alternateName Istituti Fisioterapici Ospitalieri
    229 schema:name Biostatistical Unit, Regina Elena National Cancer Institute, Rome, Italy
    230 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...