Testosterone Deficiency is Not Protective Against the Development of Adenocarcinoma of the Prostate in a Type 1 Diabetic Patient View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-04-07

AUTHORS

David S. H. Bell, Terri Jerkins

ABSTRACT

We present a case of prostate cancer (PC) developing in a hypogonadal patient with well-controlled type 1 diabetes. The purpose of reporting this case is to emphasize that regular prostate examinations and prostate-specific antigen (PSA) measurements should be preformed in the diabetic male, even though the incidence of PC is lower in this group of patients. In addition, these examinations and tests need to be preformed even in the hypogonadal patient with diabetes since the presence of a low serum testosterone (T) level does not preclude the development of PC. This is because the development of PC is not related to serum androgen levels but to the androgen levels within the prostate, and dihydrotestosterone (DHT) levels and not T levels within the prostate gland are responsible for the development of PC. In the hypogonadal male, intraprostatic DHT may be high since DHT can be formed from adrenal androgens, particularly androstenedione, through activation of 5α-reductase 2, which is the minority enzyme in the normal prostate but becomes the major enzyme in the formation and growth of PC. More... »

PAGES

1115-1119

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s13300-022-01256-6

DOI

http://dx.doi.org/10.1007/s13300-022-01256-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1146945143

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35391594


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Southside Endocrinology, 1900 Crestwood Blvd, Suite 201, 35210, Irondale, AL, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Southside Endocrinology, 1900 Crestwood Blvd, Suite 201, 35210, Irondale, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bell", 
        "givenName": "David S. H.", 
        "id": "sg:person.0723453627.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723453627.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lipscomb University, Nashville, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.440609.f", 
          "name": [
            "Lipscomb University, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jerkins", 
        "givenName": "Terri", 
        "id": "sg:person.01122114507.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122114507.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrurol.2014.338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016002676", 
          "https://doi.org/10.1038/nrurol.2014.338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11934-018-0812-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105222975", 
          "https://doi.org/10.1007/s11934-018-0812-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-04-07", 
    "datePublishedReg": "2022-04-07", 
    "description": "We present a case of prostate cancer (PC) developing in a hypogonadal patient with well-controlled type\u00a01 diabetes. The purpose of reporting this case is to emphasize that regular prostate examinations and prostate-specific antigen (PSA) measurements should be preformed in the diabetic male, even though the incidence of PC is lower in this group of patients. In addition, these examinations and tests need to be preformed even in the hypogonadal patient with diabetes since the presence of a low serum testosterone (T) level does not preclude the development of PC. This is because the development of PC is not related to serum androgen levels but to the androgen levels within the prostate, and dihydrotestosterone (DHT) levels and not T\u00a0levels within the prostate gland are responsible for the development of PC. In the hypogonadal male, intraprostatic DHT may be high since DHT can be formed from adrenal androgens, particularly androstenedione, through activation of 5\u03b1-reductase\u00a02, which is the minority enzyme in the normal prostate but becomes the major enzyme in the formation and growth of PC.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s13300-022-01256-6", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1044057", 
        "issn": [
          "1869-6953", 
          "1869-6961"
        ], 
        "name": "Diabetes Therapy", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "development of PCa", 
      "prostate cancer", 
      "hypogonadal patients", 
      "androgen levels", 
      "incidence of PCa", 
      "low serum testosterone levels", 
      "type 1 diabetic patients", 
      "prostate specific antigen measurements", 
      "growth of PCa", 
      "serum androgen levels", 
      "group of patients", 
      "serum testosterone levels", 
      "development of adenocarcinoma", 
      "diabetic males", 
      "hypogonadal males", 
      "adrenal androgens", 
      "testosterone deficiency", 
      "diabetic patients", 
      "dihydrotestosterone levels", 
      "prostate examination", 
      "testosterone levels", 
      "antigen measurement", 
      "normal prostate", 
      "prostate gland", 
      "patients", 
      "prostate", 
      "diabetes", 
      "major enzyme", 
      "males", 
      "examination", 
      "DHT", 
      "levels", 
      "adenocarcinoma", 
      "androgens", 
      "androstenedione", 
      "cancer", 
      "incidence", 
      "gland", 
      "cases", 
      "activation", 
      "deficiency", 
      "enzyme", 
      "group", 
      "development", 
      "test", 
      "presence", 
      "purpose", 
      "addition", 
      "types", 
      "growth", 
      "measurements", 
      "formation"
    ], 
    "name": "Testosterone Deficiency is Not Protective Against the Development of Adenocarcinoma of the Prostate in a Type 1 Diabetic Patient", 
    "pagination": "1115-1119", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1146945143"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s13300-022-01256-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35391594"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s13300-022-01256-6", 
      "https://app.dimensions.ai/details/publication/pub.1146945143"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_937.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s13300-022-01256-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s13300-022-01256-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s13300-022-01256-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s13300-022-01256-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s13300-022-01256-6'


 

This table displays all metadata directly associated to this object as RDF triples.

131 TRIPLES      21 PREDICATES      79 URIs      69 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s13300-022-01256-6 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N1a1068f60623450aa271f7d2fffac426
4 schema:citation sg:pub.10.1007/s11934-018-0812-1
5 sg:pub.10.1038/nrurol.2014.338
6 schema:datePublished 2022-04-07
7 schema:datePublishedReg 2022-04-07
8 schema:description We present a case of prostate cancer (PC) developing in a hypogonadal patient with well-controlled type 1 diabetes. The purpose of reporting this case is to emphasize that regular prostate examinations and prostate-specific antigen (PSA) measurements should be preformed in the diabetic male, even though the incidence of PC is lower in this group of patients. In addition, these examinations and tests need to be preformed even in the hypogonadal patient with diabetes since the presence of a low serum testosterone (T) level does not preclude the development of PC. This is because the development of PC is not related to serum androgen levels but to the androgen levels within the prostate, and dihydrotestosterone (DHT) levels and not T levels within the prostate gland are responsible for the development of PC. In the hypogonadal male, intraprostatic DHT may be high since DHT can be formed from adrenal androgens, particularly androstenedione, through activation of 5α-reductase 2, which is the minority enzyme in the normal prostate but becomes the major enzyme in the formation and growth of PC.
9 schema:genre article
10 schema:isAccessibleForFree true
11 schema:isPartOf N130b2556a6d14927a1020c7fa245be82
12 N6eab363c2b604648b18eb1f0e06c68c6
13 sg:journal.1044057
14 schema:keywords DHT
15 activation
16 addition
17 adenocarcinoma
18 adrenal androgens
19 androgen levels
20 androgens
21 androstenedione
22 antigen measurement
23 cancer
24 cases
25 deficiency
26 development
27 development of PCa
28 development of adenocarcinoma
29 diabetes
30 diabetic males
31 diabetic patients
32 dihydrotestosterone levels
33 enzyme
34 examination
35 formation
36 gland
37 group
38 group of patients
39 growth
40 growth of PCa
41 hypogonadal males
42 hypogonadal patients
43 incidence
44 incidence of PCa
45 levels
46 low serum testosterone levels
47 major enzyme
48 males
49 measurements
50 normal prostate
51 patients
52 presence
53 prostate
54 prostate cancer
55 prostate examination
56 prostate gland
57 prostate specific antigen measurements
58 purpose
59 serum androgen levels
60 serum testosterone levels
61 test
62 testosterone deficiency
63 testosterone levels
64 type 1 diabetic patients
65 types
66 schema:name Testosterone Deficiency is Not Protective Against the Development of Adenocarcinoma of the Prostate in a Type 1 Diabetic Patient
67 schema:pagination 1115-1119
68 schema:productId N426e5674ce4b4ab39f9ec012cd534954
69 N7f9fcb0dd04f478eb974bcf9fa3bb256
70 Na5d3921707d741ffb14d6a5310d87871
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1146945143
72 https://doi.org/10.1007/s13300-022-01256-6
73 schema:sdDatePublished 2022-08-04T17:12
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N81cacb1ec21b41939b8721fa65bdcb0f
76 schema:url https://doi.org/10.1007/s13300-022-01256-6
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N130b2556a6d14927a1020c7fa245be82 schema:volumeNumber 13
81 rdf:type schema:PublicationVolume
82 N1a1068f60623450aa271f7d2fffac426 rdf:first sg:person.0723453627.37
83 rdf:rest N4ce63b26961d40d5969b781df31e16af
84 N426e5674ce4b4ab39f9ec012cd534954 schema:name pubmed_id
85 schema:value 35391594
86 rdf:type schema:PropertyValue
87 N4ce63b26961d40d5969b781df31e16af rdf:first sg:person.01122114507.11
88 rdf:rest rdf:nil
89 N6eab363c2b604648b18eb1f0e06c68c6 schema:issueNumber 5
90 rdf:type schema:PublicationIssue
91 N7f9fcb0dd04f478eb974bcf9fa3bb256 schema:name doi
92 schema:value 10.1007/s13300-022-01256-6
93 rdf:type schema:PropertyValue
94 N81cacb1ec21b41939b8721fa65bdcb0f schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 Na5d3921707d741ffb14d6a5310d87871 schema:name dimensions_id
97 schema:value pub.1146945143
98 rdf:type schema:PropertyValue
99 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
100 schema:name Medical and Health Sciences
101 rdf:type schema:DefinedTerm
102 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
103 schema:name Clinical Sciences
104 rdf:type schema:DefinedTerm
105 sg:journal.1044057 schema:issn 1869-6953
106 1869-6961
107 schema:name Diabetes Therapy
108 schema:publisher Springer Nature
109 rdf:type schema:Periodical
110 sg:person.01122114507.11 schema:affiliation grid-institutes:grid.440609.f
111 schema:familyName Jerkins
112 schema:givenName Terri
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122114507.11
114 rdf:type schema:Person
115 sg:person.0723453627.37 schema:affiliation grid-institutes:None
116 schema:familyName Bell
117 schema:givenName David S. H.
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723453627.37
119 rdf:type schema:Person
120 sg:pub.10.1007/s11934-018-0812-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105222975
121 https://doi.org/10.1007/s11934-018-0812-1
122 rdf:type schema:CreativeWork
123 sg:pub.10.1038/nrurol.2014.338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016002676
124 https://doi.org/10.1038/nrurol.2014.338
125 rdf:type schema:CreativeWork
126 grid-institutes:None schema:alternateName Southside Endocrinology, 1900 Crestwood Blvd, Suite 201, 35210, Irondale, AL, USA
127 schema:name Southside Endocrinology, 1900 Crestwood Blvd, Suite 201, 35210, Irondale, AL, USA
128 rdf:type schema:Organization
129 grid-institutes:grid.440609.f schema:alternateName Lipscomb University, Nashville, TN, USA
130 schema:name Lipscomb University, Nashville, TN, USA
131 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...